{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:22:56Z","timestamp":1770834176206,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["20241160"],"award-info":[{"award-number":["20241160"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Limited data exist on characteristics and clinical outcomes associated with anxiety and\/or depression in heart failure (HF) across the different ejection fraction (EF) categories, particularly when considering aspects of health-related quality of life (HRQoL). To assess characteristics and clinical outcomes associated with anxiety and\/or depression in patients with preserved, mildly reduced, and reduced EF (HFpEF, HFmrEF, and HFrEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were included from the Swedish Heart Failure Registry in 2008\u201323. Anxiety and\/or depression levels (none, moderate, or severe) were self-reported using the EuroQoL five-dimensional three-level questionnaire (EQ-5D-3L). Multivariable multinomial regression was used to analyse baseline characteristics independently associated with self-reported anxiety\/depression, with and without HRQoL adjustment. Time-to-first HF hospitalization (HFH), all-cause hospitalization, all-cause and cardiovascular (CV) death were assessed using Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 57 251 patients, 58% reported no, 38% moderate, and 4% severe symptoms of anxiety\/depression, with similar distributions across EF categories. Self-reported anxiety\/depression were associated with reduced HRQoL components. Without HRQoL adjustment, significant associations included higher NYHA class, liver disease, smoking, female sex, younger age, and inpatient status. Self-reported anxiety\/depression levels were associated with higher risks of all outcomes at 12 months. After HRQoL adjustments, self-reported anxiety\/depression remained associated with HFH and all-cause hospitalization but not death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Self-reported anxiety\/depression were common across all HF categories, significantly associated with HRQoL, and associated with increased risk of HFH, all-cause hospitalization and death, but their impact on mortality diminished after adjustment for HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvaf024","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:02:17Z","timestamp":1767862937000},"source":"Crossref","is-referenced-by-count":0,"title":["Anxiety and\/or depression in heart failure across the ejection fraction spectrum: the SwedeHF 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