{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:22:51Z","timestamp":1770834171986,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health-Ricerca Corrente to Centro Cardiologico Monzino IRCCS","award":["B43C24000090001"],"award-info":[{"award-number":["B43C24000090001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In heart failure (HF) patients, guidelines recommend scores for assessing outcomes and heart transplant (HTX) eligibility. However, scores use remains limited and cut-off values for HTX listing not well established.<\/jats:p>\n                    <jats:p>Among the available tools, MECKI score is easy to calculate and likely offers the best prognostic accuracy. Compare MECKI score-based survival with that of HTX recipients and identify a MECKI threshold above which survival is inferior to that of HTX recipients at 5-year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive ambulatory HF patients enrolled in MECKI score programme between January 2010 and January 2022 were evaluated. Primary endpoint was a composite of cardiovascular death, HTX, or left ventricular assist device implantation. Heart transplant survival data were obtained from the International Society of Heart and Lung Transplantation registry updated through 2023. To identify the MECKI score threshold beyond which prognosis is worse than that of HTX recipients, patients were stratified by deciles of MECKI score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed 3865 HF patients (mean age 62.4 \u00b1 12.6 years). Peak VO\u2082 was 58.2 \u00b1 18.3% predicted; VE\/VCO\u2082 slope 33.2 \u00b1 8.2, haemoglobin 13.5 \u00b1 1.7\u2005g\/dL, Na\u207a 139 \u00b1 3\u2005mmol\/L, LVEF 33.7 \u00b1 10.4%, and eGFR 73 \u00b1 26\u2005mL\/min\/1.73\u2005m\u00b2. Periodic breathing occurred in 15.8% of patients. At 5 years, mean survival was 83.7%.<\/jats:p>\n                    <jats:p>The average 5-year survival of HTX recipients (71.2%) lies between the eighth and ninth MECKI score deciles suggesting a MECKI score value \u22650.1368 as the proper cut-off for HTX listing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MECKI score \u22650.1368 may warrant HTX listing, while lower scores support clinical deferral.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvaf033","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:31:13Z","timestamp":1767702673000},"source":"Crossref","is-referenced-by-count":0,"title":["MECKI score thresholds for heart transplantation referral of ambulatory heart failure patients"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-6382","authenticated-orcid":false,"given":"Piergiuseppe","family":"Agostoni","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan , Via Parea 4, 20138, Milan ,","place":["Italy"]},{"name":"Centro Cardiologico Monzino, IRCCS , Via Parea 4, 20138, Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Galotta","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS , Via Parea 4, 20138, Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Salvioni","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS , Via Parea 4, 20138, Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-7407","authenticated-orcid":false,"given":"Massimo","family":"Mapelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan , Via Parea 4, 20138, Milan ,","place":["Italy"]},{"name":"Centro Cardiologico Monzino, IRCCS , Via Parea 4, 20138, Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Pisa ,","place":["Italy"]},{"name":"Cardio-Thoracic Department, Fondazione Toscana Gabriele Monasterio , Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Piepoli","sequence":"additional","affiliation":[{"name":"Clinical Cardiology, IRCCS Policlinico San Donato , Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences for Health, University of Milan , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-984X","authenticated-orcid":false,"given":"Alberto","family":"Palazzuoli","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Unit, Cardio Thoracic and Vascular Department, S. 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