{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:04:48Z","timestamp":1772892288189,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Residual mitral regurgitation (MR) after mitral transcatheter edge-to-edge repair (M-TEER) is associated with adverse prognosis. However, the long-term clinical impact of MR persistence or progression has not been well stratified. We aimed to evaluate the proportion, clinical benefits, and prognostic value of maintaining mild MR 1 year after M-TEER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>This multi-centre registry-based analysis included 1865 patients who achieved mild MR at discharge following M-TEER. At 1 year, patients were classified as having stable MR (\u2264 mild) or worsening MR (\u2265 moderate). The frequency of left atrial (LA) and left ventricular (LV) reverse remodelling and tricuspid regurgitation (TR) improvement were assessed from baseline to 1 year. Clinical endpoints\u2014including all-cause mortality and heart failure hospitalization\u2014were evaluated beyond 1 year after M-TEER up to 2 years. Worsening MR occurred in 28.4% of patients. Compared with the worsening MR group, the stable MR group demonstrated significantly more frequent LA and LV reverse remodelling (38.4% vs 28.1%, and 44.7% vs 31.1%, respectively; both P &amp;lt; .001). Improvement in TR (\u2265 Grade 1) was also more prevalent in the stable MR group (32.4% vs 20.6%, P &amp;lt; .001). Worsening MR was independently associated with increased risk of adverse clinical outcomes (hazard ratio: 2.02; 95% confidence interval: 1.26\u20133.23; P = .003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maintaining MR within mild at 1-year post-M-TEER is associated with favourable cardiac reverse remodelling and improved clinical prognosis. These findings underscore the importance of long-term MR surveillance and its implications for outcome optimization following M-TEER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag016","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:51:02Z","timestamp":1767963062000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of maintaining mild mitral regurgitation beyond 1 year after mitral transcatheter edge-to-edge repair"],"prefix":"10.1093","volume":"13","author":[{"given":"Azusa","family":"Kurita","sequence":"first","affiliation":[{"name":"Department of Cardiology, Gifu Heart Center , Gifu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-6382","authenticated-orcid":false,"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gifu Heart Center , Gifu 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Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakakibara Heart Institute , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-033X","authenticated-orcid":false,"given":"Masahiko","family":"Asami","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mitsui Memorial Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-1012","authenticated-orcid":false,"given":"Yusuke","family":"Enta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sendai Kosei Hospital , Sendai 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