{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:22:39Z","timestamp":1770834159058,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Ribeir\u00e3o Preto"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this investigation was to establish the clinical characteristics and outcomes of patients with non-dilated left ventricular cardiomyopathy (NDLVC) secondary to chronic Chagas disease (CChD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with CChD followed at our institution from January 2000 to January 2010 were included. Patients with a left ventricular ejection fraction (LVEF) &amp;lt;50%, a left ventricular diastolic diameter (LVDD) &amp;lt;55\u2005mm, and segmental wall motion abnormalities (SWMA) on echocardiography were diagnosed with NDLVC secondary to CChD. The remaining patients had dilated cardiomyopathy (DCM) secondary to CChD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 215 patients, 21 (10%) had NDLVC. In this group, the mean age was 62 \u00b1 9 years, 12 (57%) were male, the median daily dose of metoprolol was 100 (62, 5, 125) mg, the LVDD was 51 \u00b1 29 mm, and the LVEF was 39 \u00b1 6.4%. SWMA were found in 12 (57%) patients. Mean follow-up 50.8 \u00b1 3.8 months, during which 9 (43%) patients died. In a Cox regression model, Beta-blocker therapy was the only independent predictor of all-cause mortality for patients with NDLVC (hazard ratio = 0.16, 95% CI 0.04-0.68; P = .01) Over a 60-month follow-up, Kaplan-Meier survival estimates at 12, 24, 36, 48, and 60 months, were 71%, 71%, 59%, 59%, and 59%, respectively, in patients with NDLVC, and 77%, 61%, 49%, 38%, and 30%, respectively, in those with DCM due to CChD (P = .04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non-dilated left ventricular cardiomyopathy affects one in 10 patients with CHF due to CChD, and the 5-year survival rate is 59%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag020","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:49:42Z","timestamp":1767962982000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-dilated left ventricular cardiomyopathy in patients with chronic Chagas disease and heart failure with reduced left ventricular ejection fraction"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-9601","authenticated-orcid":false,"given":"Reinaldo B","family":"Bestetti","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Ribeir\u00e3o Preto , Ribeir\u00e3o Preto city 14096-900 ,","place":["Brazil"]},{"name":"Division of Postgraduation, S\u00e3o Jos\u00e9 do Rio Preto Medical School, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Cardinalli-Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-0297","authenticated-orcid":false,"given":"Ana Paula","family":"Otaviano","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio N","family":"Machado","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo R","family":"Pavarino","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, S\u00e3o Jos\u00e9 do Rio Preto Medical School, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-7056","authenticated-orcid":false,"given":"Marcelo A","family":"Nakazone","sequence":"additional","affiliation":[{"name":"Division of Postgraduation, S\u00e3o Jos\u00e9 do Rio Preto Medical School, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]},{"name":"Funda\u00e7\u00e3o Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]},{"name":"Department of Cardiology and Cardiovascular Surgery, S\u00e3o Jos\u00e9 do Rio Preto Medical School, S\u00e3o Jos\u00e9 do Rio Preto city ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"2026021112471932900_xvag020-B1","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC guidelines for the 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