{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:36:24Z","timestamp":1791999384150,"version":"4.4.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute myocarditis can lead to chronic inflammatory cardiomyopathy (Infl-CMP), a condition characterized by increased risk of ventricular arrhythmias (VA), left ventricular (LV) systolic dysfunction (LVSD), and heart failure (HF). Immunosuppressive therapy is generally not recommended for Infl-CMP when diagnosed non-invasively by cardiac magnetic resonance imaging (CMRI) or fluorodeoxyglucose-positron emission tomography (FDG-PET). We are assessing, in the CMP-MYTHiC trial, whether colchicine (0.5\u2005mg in patients &amp;lt;70\u2005kg or 1\u2005mg in patients \u226570\u2005kg), an immunomodulatory drug with a good safety profile, can reduce myocardial inflammation in patients with Infl-CMP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>The CMP-MYTHiC, a multicenter investigator-initiated single-blinded randomized controlled trial, screens adult patients diagnosed with Infl-CMP by CMRI or FDG-PET within the prior 3 months at 12 Italian centres. Eligibility is further defined by the presence of VA or LVSD\/HF phenotype. VA phenotype is determined by a high burden of premature ventricular complexes (PVCs) on baseline 24-h ECG ambulatory monitoring, non-sustained ventricular tachycardia (NSVT), or sustained ventricular tachycardia (SVT). The LVSD\/HF phenotype is characterized by reduced LV ejection fraction (LVEF &amp;lt;50% on echocardiogram or &amp;lt;60% on CMRI) or elevated natriuretic peptide levels. Key exclusion criteria include a history of myocardial infarction, cardiomyopathy attributed to other specific causes, and systemic autoimmune disorders.<\/jats:p>\n                    <jats:p>The efficacy of colchicine compared with placebo will be assessed when CMRI or FDG-PET scans and 24-h ambulatory ECG monitoring are repeated at 6 months after randomization. The primary endpoint of the trial analysed according to the intention-to-treat population is the proportion of patients who are alive and free from any clinical (cardiac death or hospitalization due to HF or VA episodes), arrhythmic (PVC burden increase \u226550%, NSVT increase \u226530%, or any SVT), or imaging (LVEF reduction &amp;gt;10% or new areas of oedema plus increased inflammation) worsening, and who demonstrate improvement in either imaging (reduction in oedema on CMRI or FDG uptake) or arrhythmic (PVC burden reduction \u226570% with no NSVT\/SVT) outcomes at 6 months. Assuming 80% power with an overall type I error of 0.025 using one-sided Fisher's Exact test, 40 patients per group are required to demonstrate that the primary endpoint will be reached in 66% of patients in the colchicine group compared with 33% in the placebo. Twenty-nine patients were randomized since December 2023, and the conclusion is expected in 2029.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results can define the role of colchicine in treating patients with Infl-CMP non-invasively diagnosed by CMRI or FDG-PET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinicaltrials.gov identifier<\/jats:title>\n                    <jats:p>NCT06158698.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag058","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:28:54Z","timestamp":1771331334000},"source":"Crossref","is-referenced-by-count":5,"title":["Colchicine in patients with chronic inflammatory cardiomyopathy: rationale and design of the CMP-MYTHiC"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1676-5257","authenticated-orcid":false,"given":"Enrico","family":"Ammirati","sequence":"first","affiliation":[{"name":"De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda , Piazza Ospedale Maggiore 3, 20162 Milano ,","place":["Italy"]},{"name":"School of Medicine and Surgery, University of Milano-Bicocca , Via Cadore 48, 20900 Monza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iside","family":"Cartella","sequence":"additional","affiliation":[{"name":"De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda , Piazza Ospedale Maggiore 3, 20162 Milano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-4537","authenticated-orcid":false,"given":"Michele","family":"Ciabatti","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, San Donato, Hospital , Arezzo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5341-8302","authenticated-orcid":false,"given":"Giada","family":"Colombo","sequence":"additional","affiliation":[{"name":"De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda , Piazza Ospedale Maggiore 3, 20162 Milano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Masetti","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pieroni","sequence":"additional","affiliation":[{"name":"Cardiomyopathy Unit, Department of Clinical and Experimental Medicine University of Florence, Careggi University Hospital , Florence ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, \u2018Citta della Salute e della Scienza\u2019 Hospital , Turin ,","place":["Italy"]},{"name":"Department of Medical Sciences, University of Turin , Turin ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Peretto","sequence":"additional","affiliation":[{"name":"Disease Unit for Myocarditis and Arrhythmogenic Cardiomyopathies, IRCCS San Raffaele Scientific Institute , Milano ,","place":["Italy"]},{"name":"Cardiac Electrophysiology Department, IRCCS San Raffaele Scientific Institute , Milano ,","place":["Italy"]},{"name":"School of Medicine and Surgery, Vita-Salute San Raffaele University , Milano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Potena","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna ,","place":["Italy"]},{"name":"Department of Clinical and Surgical Sciences, University of Bologna, Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-4088","authenticated-orcid":false,"given":"Roberto","family":"Scacciavillani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, CUORE, Fondazione Policlinico Universitario A. 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