{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:08:01Z","timestamp":1792858081425,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Greater sodium avidity in acute heart failure (AHF) is associated with worse outcomes, but whether kidney tubule injury is associated with sodium avidity and impaired diuretic responsiveness remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated 339 participants from the ROSE-AHF trial, which enrolled patients hospitalized for AHF with kidney dysfunction and randomized them to the dopamine, nesiritide, or placebo group. Urinary kidney injury molecule-1 (KIM-1), N-acetyl-\u03b2-D-glucosaminidase (NAG), and neutrophil gelatinase-associated lipocalin (NGAL) were measured at enrolment. Associations between these biomarkers and urinary sodium (uNa) concentration at baseline, fractional excretion of sodium (FeNa), as well as total uNa output and urine output over 72-h were assessed using multivariable regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher KIM-1 and NAG values at baseline were associated with lower uNa concentration at baseline [\u22126.1% (\u22128.5%, \u22123.7%), P &amp;lt; 0.001 and \u22125.9% (\u22129.2%, \u22122.6%), P &amp; .001, respectively, per two-fold increase in each biomarker]. Higher baseline KIM-1 and NAG were also associated with lower FeNa [\u22126.1% (\u22128.5%, \u22123.6%), P &amp;lt; .001 and \u22125.2% (\u22128.6%, \u22123.6%), P = 0 .001, respectively, per two-fold increase in each biomarker]. Higher baseline KIM-1 was associated with lower total uNa excretion over 72-h [\u22123.6% (\u22126.8%, \u22120.2%), P = 0.037 per two-fold increase]. None of the biomarkers were associated with urine output over 72-h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Kidney tubular injury, as assessed by urine KIM-1 and NAG, is associated with greater sodium avidity and higher KIM-1 is associated with impaired diuretic responsiveness in AHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag079","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:40:55Z","timestamp":1773330055000},"source":"Crossref","is-referenced-by-count":2,"title":["Kidney tubule injury is associated with sodium avidity and diuretic responsiveness in acute heart failure"],"prefix":"10.1093","volume":"13","author":[{"given":"Yu","family":"Horiuchi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Mitsui Memorial Hospital , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-1181","authenticated-orcid":false,"given":"Stephen","family":"Duff","sequence":"additional","affiliation":[{"name":"School of Medicine, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J","family":"van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M","family":"Estrella","sequence":"additional","affiliation":[{"name":"Nephrology Section, San Francisco Veterans Affairs Healthcare System , San Francisco, CA ,","place":["USA"]},{"name":"Kidney Health Research Collaborative, Department of Medicine, SanFrancisco VA Healthcare System , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G","family":"Shlipak","sequence":"additional","affiliation":[{"name":"Kidney Health Research Collaborative, Department of Medicine, SanFrancisco VA Healthcare System , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimitsu","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of California , San Diego, La Jolla, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Medicine, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, and Veterans Affairs San Diego Healthcare System , San Diego, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-1152","authenticated-orcid":false,"given":"Nicholas","family":"Wettersten","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of California , San Diego, La Jolla, CA ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, San Diego Veterans Affairs Medical Center , Cardiology 4 West, Room 4022 (111A), 3350 La Jolla Village Drive, San Diego, CA 92161 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"2026033109312578900_xvag079-B1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/ejhf.1369","article-title":"The use of diuretics in heart failure with congestion\u2014a position statement from the Heart Failure Association of the 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