{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T01:46:20Z","timestamp":1776044780693,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To build a comprehensive biobank integrated in the Swedish Heart Failure Registry (SwedeHF) comprising comprehensive clinomic data, proteomic, transcriptomic and genomic information in combination with clinical and diagnostic characteristics and additional ICD-code registry data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood and urine samples will be biobanked at SwedeHF registration with an optional second sampling after 6 months in patients with HF attending routine clinical visits at nine hospitals with access to healthcare integrated biobanking. Circulating and urine biomarkers will be investigated by proteomic, metabolomic, transcriptomic profiling, explored with genetic data. Sample size assessments were based on the BIOSTAT-CHF cohort and doubled to fulfil all aims targeting 5000 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The first 1348 enrolled patients were median 72 years, 30% females, 65% HFrEF and 11% HFpEF. Median NT-proBNP was 1240 (quartile 1\u20133; 470\u20132830) pg\/mL. This was comparable to the 8506 patients with an index registration in SwedeHF during 2023 with 52% HFrEF and 20% HFpEF, age 75 years, 36% females and NT-proBNP 1560 [629\u20133617] pg\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We are building a high-quality detailed biobank linked to SwedeHF, the world\u2019s largest continuous HF registry, consisting of plasma, serum, whole blood and urine samples. The Biobank will enable studies exploring underlying disease mechanisms in HF and response to HF treatment, paving the way for precision medicine and novel drug targets. It will also generate a structure for biobanking in Registry-based Randomized Controlled Trials within the national SwedeHF registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.gov Identifier<\/jats:title>\n                    <jats:p>NCT06435585<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag092","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:26:09Z","timestamp":1775561169000},"source":"Crossref","is-referenced-by-count":0,"title":["An integrated Biobank in the Swedish Heart Failure Registry\u2014clinomics, proteomics, transcriptomics and genomics"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-2416","authenticated-orcid":false,"given":"Camilla","family":"Hage","sequence":"first","affiliation":[{"name":"Department of Medicine, Karolinska Institutet , Stockholm S-171 64 ,","place":["Sweden"]},{"name":"Department of Cardiology, Karolinska University Hospital , Stockholm S-171 64 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Andersson","sequence":"additional","affiliation":[{"name":"Departement of Public Health and Clinical Medicine, Umea University Hospital , Ume\u00e5S-901 85 \u00a0","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-8084","authenticated-orcid":false,"given":"Christina","family":"Christersson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology, Uppsala University , Uppsala S-751 85 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-6023","authenticated-orcid":false,"given":"Cecilia","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet , Stockholm S-171 64 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars H","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Karolinska University Hospital , Stockholm S-171 64 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-0245","authenticated-orcid":false,"given":"Patric","family":"Karlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ryhov Hospital , J\u00f6nk\u00f6ping S-551 85 ,","place":["Sweden"]},{"name":"Department of Health, Medicine and Caring Sciences, Link\u00f6ping University , Link\u00f6ping S-581 91 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Chatziapostolou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 S-205 02 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viveka","family":"Dagner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Lund University and Sk\u00e5ne University Hospital , Lund S-221 85 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frida","family":"Granstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Karolinska University Hospital , Stockholm S-171 64 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Gylling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University , Link\u00f6ping S-581 91 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ryhov Hospital , J\u00f6nk\u00f6ping S-551 85 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernilla","family":"Haglund","sequence":"additional","affiliation":[{"name":"Heart-, Lung- and Physiology Clinic, \u00d6rebro University Hospital , \u00d6rebro S-701 85 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"H\u00f6gberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Karolinska University Hospital , Stockholm S-171 64 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Odenstedt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sahlgrenska University Hospital\/\u00d6stra Sjukhuset , G\u00f6teborg S-416 85 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika","family":"Viklund","sequence":"additional","affiliation":[{"name":"Departement of Public Health and Clinical Medicine, Umea University Hospital , Ume\u00e5S-901 85 \u00a0","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-5936","authenticated-orcid":false,"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 S-205 02 ,","place":["Sweden"]},{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 S-221 85 ,","place":["Sweden"]},{"name":"Wallenberg Center for Molecular Medicine, Lund University , Lund S-221 85 ,","place":["Sweden"]},{"name":"Hypertension in Africa Research Team (HART), North-West University , Potchefstroom ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6285-9935","authenticated-orcid":false,"given":"J Gustav","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Lund University and Sk\u00e5ne University Hospital , Lund S-221 85 ,","place":["Sweden"]},{"name":"Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University , Lund S-221 85 ,","place":["Sweden"]},{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital , Gothenburg S-418 77 ,","place":["Sweden"]},{"name":"Science for Life Laboratory, Gothenburg University , Gothenburg S-418 77 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barna","family":"Szab\u00f3-S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Heart-, Lung- and Physiology Clinic, \u00d6rebro University Hospital , \u00d6rebro S-701 85 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"\u00d6stg\u00e4rd Thunstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sahlgrenska University Hospital\/\u00d6stra Sjukhuset , G\u00f6teborg S-416 85 ,","place":["Sweden"]},{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University , Gothenburg S-418 77 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Dahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University , Link\u00f6ping S-581 91 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"2026041221175213000_xvag092-B1","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.15420\/cfr.2023.05","article-title":"Global public health burden of heart failure: an updated review","volume":"9","author":"Shahim","year":"2023","journal-title":"Card Fail Rev"},{"key":"2026041221175213000_xvag092-B2","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/ejhf.3506","article-title":"Trends in heart failure mortality in Sweden between 1997 and 2022","volume":"27","author":"Lindberg","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B3","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2026041221175213000_xvag092-B4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/ejhf.2115","article-title":"Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association","volume":"23","author":"Bozkurt","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41569-021-00605-5","article-title":"Heart failure with mid-range or mildly reduced ejection fraction","volume":"19","author":"Savarese","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"2026041221175213000_xvag092-B6","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1002\/ejhf.3230","article-title":"Cause-specific death in heart failure across the ejection fraction spectrum: a comprehensive assessment of over 100 000 patients in the Swedish Heart Failure Registry","volume":"26","author":"Settergren","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B7","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1002\/ehf2.14302","article-title":"Long-term outcomes in heart failure with preserved ejection fraction: predictors of cardiac and non-cardiac mortality","volume":"10","author":"Shahim","year":"2023","journal-title":"ESC Heart Fail"},{"key":"2026041221175213000_xvag092-B8","doi-asserted-by":"publisher","first-page":"e001633","DOI":"10.1161\/CIRCGENETICS.116.001633","article-title":"Inflammatory biomarkers predict heart failure severity and prognosis in patients with heart failure with preserved ejection fraction: a holistic proteomic approach","volume":"10","author":"Hage","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"2026041221175213000_xvag092-B9","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1136\/heartjnl-2015-308852","article-title":"Microvascular endothelial dysfunction in heart failure with preserved ejection fraction","volume":"102","author":"Lam","year":"2016","journal-title":"Heart"},{"key":"2026041221175213000_xvag092-B10","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1161\/CIRCRESAHA.121.318159","article-title":"From systemic inflammation to myocardial fibrosis: the heart failure with preserved ejection fraction paradigm revisited","volume":"128","author":"Paulus","year":"2021","journal-title":"Circ Res"},{"key":"2026041221175213000_xvag092-B11","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J"},{"key":"2026041221175213000_xvag092-B12","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1056\/NEJMoa2407107","article-title":"Finerenone in heart failure with mildly reduced or preserved ejection fraction","volume":"391","author":"Solomon","year":"2024","journal-title":"N Engl J Med"},{"key":"2026041221175213000_xvag092-B13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0140-6736(24)01643-X","article-title":"Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials","volume":"404","author":"Kosiborod","year":"2024","journal-title":"Lancet"},{"key":"2026041221175213000_xvag092-B14","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1002\/ejhf.3453","article-title":"The spironolactone initiation registry randomized interventional trial in heart failure with preserved ejection fraction (SPIRRIT-HFpEF): rationale and design","volume":"26","author":"Lund","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B15","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1002\/ejhf.762","article-title":"Association between enrolment in a heart failure quality registry and subsequent mortality-a nationwide cohort study","volume":"19","author":"Lund","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/03009734.2018.1490831","article-title":"The Swedish Heart Failure Registry: a living, ongoing quality assurance and research in heart failure","volume":"124","author":"Savarese","year":"2019","journal-title":"Ups J Med Sci"},{"key":"2026041221175213000_xvag092-B17","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1002\/ejhf.3336","article-title":"Biologically active adrenomedullin as a marker for residual congestion and early rehospitalization in patients hospitalized for acute heart failure: data from STRONG-HF","volume":"26","author":"Voordes","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B18","doi-asserted-by":"publisher","first-page":"131664","DOI":"10.1016\/j.ijcard.2023.131664","article-title":"Differential biomarker expression in heart failure patients with and without mitral regurgitation: insights from BIOSTAT-CHF","volume":"399","author":"Adamo","year":"2024","journal-title":"Int J Cardiol"},{"key":"2026041221175213000_xvag092-B19","doi-asserted-by":"publisher","first-page":"e000260","DOI":"10.1136\/openhrt-2015","article-title":"Copeptin in patients with heart failure and preserved ejection fraction: a report from the prospective KaRen-study","volume":"2","author":"Hage","year":"2015","journal-title":"Open Heart"},{"key":"2026041221175213000_xvag092-B20","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.3390\/jcm12175695","article-title":"Biomarkers of collagen metabolism are associated with left ventricular function and prognosis in dilated cardiomyopathy: a multi-modal study","volume":"12","author":"Raafs","year":"2023","journal-title":"J Clin Med"},{"key":"2026041221175213000_xvag092-B21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/14728222.2024.2316735","article-title":"TGF-\u03b2 as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities","volume":"28","author":"Frangogiannis","year":"2024","journal-title":"Expert Opin Ther Targets"},{"key":"2026041221175213000_xvag092-B22","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/ehf2.12615","article-title":"Circulating neuregulin1-\u03b2 in heart failure with preserved and reduced left ventricular ejection fraction","volume":"7","author":"Hage","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2026041221175213000_xvag092-B23","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.amjcard.2018.02.041","article-title":"Comparison of prognostic usefulness of serum insulin-like growth factor-binding protein 7 in patients with heart failure and preserved versus reduced left ventricular ejection fraction","volume":"121","author":"Hage","year":"2018","journal-title":"Am J Cardiol"},{"key":"2026041221175213000_xvag092-B24","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/joim.13456","article-title":"Micronutrient deficiencies in heart failure: mitochondrial dysfunction as a common pathophysiological mechanism?","volume":"291","author":"Bomer","year":"2022","journal-title":"J Intern Med"},{"key":"2026041221175213000_xvag092-B25","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1161\/CIRCULATIONAHA.116.025446","article-title":"Emerging affinity-based proteomic technologies for large-scale plasma profiling in cardiovascular disease","volume":"135","author":"Smith","year":"2017","journal-title":"Circulation"},{"key":"2026041221175213000_xvag092-B26","doi-asserted-by":"publisher","first-page":"316ra193","DOI":"10.1126\/scitranslmed.aac7071","article-title":"Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker","volume":"7","author":"Ju","year":"2015","journal-title":"Sci Transl Med"},{"key":"2026041221175213000_xvag092-B27","doi-asserted-by":"publisher","first-page":"8933","DOI":"10.1038\/s41598-024-59388-7","article-title":"Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts","volume":"14","author":"Ghosh","year":"2024","journal-title":"Sci Rep"},{"key":"2026041221175213000_xvag092-B28","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jchf.2017.07.009","article-title":"Targeted metabolomic profiling of plasma and survival in heart failure patients","volume":"5","author":"Lanfear","year":"2017","journal-title":"JACC Heart Fail"},{"key":"2026041221175213000_xvag092-B29","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.cardfail.2020.07.010","article-title":"Metabolomic profile in HFpEF vs HFrEF patients","volume":"26","author":"Hage","year":"2020","journal-title":"J Card Fail"},{"key":"2026041221175213000_xvag092-B30","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s12872-021-02146-8","article-title":"Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis","volume":"21","author":"Kolur","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"2026041221175213000_xvag092-B31","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/s41588-024-02064-3","article-title":"Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes","volume":"57","author":"Henry","year":"2025","journal-title":"Nat Genet"},{"key":"2026041221175213000_xvag092-B32","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1161\/CIRCRESAHA.111.247452","article-title":"Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?","volume":"110","author":"Creemers","year":"2012","journal-title":"Circ Res"},{"key":"2026041221175213000_xvag092-B33","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/ejhf.531","article-title":"A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure: rationale, design, and baseline characteristics of BIOSTAT-CHF","volume":"18","author":"Voors","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.cardfail.2013.01.007","article-title":"The Singapore Heart Failure Outcomes and Phenotypes (SHOP) study and prospective evaluation of outcome in patients with heart failure with preserved left ventricular ejection fraction (PEOPLE) study: rationale and design","volume":"19","author":"Santhanakrishnan","year":"2013","journal-title":"J Card Fail"},{"key":"2026041221175213000_xvag092-B35","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1097\/JCMA.0000000000000102","article-title":"The role of N-terminal pro-B-type natriuretic peptide in prognostic evaluation of heart failure","volume":"82","author":"Lam","year":"2019","journal-title":"J Chin Med Assoc"},{"key":"2026041221175213000_xvag092-B36","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1001\/jama.2017.10565","article-title":"Effect of natriuretic peptide-guided therapy on hospitalization or cardiovascular mortality in high-risk patients with heart failure and reduced ejection fraction: a randomized clinical trial","volume":"318","author":"Felker","year":"2017","journal-title":"JAMA"},{"key":"2026041221175213000_xvag092-B37","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s10741-021-10105-w","article-title":"Biomarkers for the diagnosis and management of heart failure","volume":"27","author":"Castiglione","year":"2022","journal-title":"Heart Fail Rev"},{"key":"2026041221175213000_xvag092-B38","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1016\/j.jacc.2023.08.053","article-title":"Multiomics analysis provides novel pathways related to progression of heart failure","volume":"82","author":"Ouwerkerk","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2026041221175213000_xvag092-B39","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1093\/eurheartj\/ehad100","article-title":"Acyl ghrelin improves cardiac function in heart failure and increases fractional shortening in cardiomyocytes without calcium mobilization","volume":"44","author":"Lund","year":"2023","journal-title":"Eur Heart J"},{"key":"2026041221175213000_xvag092-B40","doi-asserted-by":"publisher","first-page":"131834","DOI":"10.1016\/j.ijcard.2024.131834","article-title":"Inflammation and myeloperoxidase\u2014the next treatment targets in heart failure?","volume":"401","author":"Hage","year":"2024","journal-title":"Int J Cardiol"},{"key":"2026041221175213000_xvag092-B41","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1002\/ejhf.3156","article-title":"Distinguishing heart failure with reduced ejection fraction from heart failure with preserved ejection fraction: a phenomics approach","volume":"26","author":"van Essen","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026041221175213000_xvag092-B42","doi-asserted-by":"publisher","first-page":"14871","DOI":"10.1038\/s41598-024-65667-0","article-title":"Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum","volume":"14","author":"Andrzejczyk","year":"2024","journal-title":"Sci Rep"},{"key":"2026041221175213000_xvag092-B43","doi-asserted-by":"publisher","first-page":"104655","DOI":"10.1016\/j.ebiom.2023.104655","article-title":"HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanisms","volume":"93","author":"Petersen","year":"2023","journal-title":"EBioMedicine"},{"key":"2026041221175213000_xvag092-B44","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1161\/CIRCULATIONAHA.120.045810","article-title":"Proteomic evaluation of the comorbidity-inflammation paradigm in heart failure with preserved ejection fraction: results from the PROMIS-HFpEF study","volume":"142","author":"Sanders-van Wijk","year":"2020","journal-title":"Circulation"},{"key":"2026041221175213000_xvag092-B45","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2217\/pgs-2018-0004","article-title":"A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure","volume":"19","author":"de Denus","year":"2018","journal-title":"Pharmacogenomics"},{"key":"2026041221175213000_xvag092-B46","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/phar.2626","article-title":"NR3C2 genotype is associated with response to spironolactone in diastolic heart failure patients from the Aldo-DHF trial","volume":"41","author":"Dumeny","year":"2021","journal-title":"Pharmacotherapy"},{"key":"2026041221175213000_xvag092-B47","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/tpj.2016.4","article-title":"A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials","volume":"17","author":"de Denus","year":"2017","journal-title":"Pharmacogenomics J"},{"key":"2026041221175213000_xvag092-B48","doi-asserted-by":"publisher","first-page":"11288","DOI":"10.1073\/pnas.0509937103","article-title":"A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure","volume":"103","author":"Liggett","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026041221175213000_xvag092-B49","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s12272-022-01394-2","article-title":"Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes","volume":"45","author":"Lee","year":"2022","journal-title":"Arch Pharm Res"},{"key":"2026041221175213000_xvag092-B50","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1002\/ehf2.14828","article-title":"Artificial intelligence-assisted automated heart failure detection and classification from electronic health records","volume":"11","author":"Oo","year":"2024","journal-title":"ESC Heart Fail"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/advance-article-pdf\/doi\/10.1093\/eschf\/xvag092\/67989157\/xvag092.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/2\/xvag092\/67989157\/xvag092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/2\/xvag092\/67989157\/xvag092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T01:17:57Z","timestamp":1776043077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/doi\/10.1093\/eschf\/xvag092\/8643912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,8]]},"published-print":{"date-parts":[[2026,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/eschf\/xvag092","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,3]]},"article-number":"xvag092"}}