{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:31:31Z","timestamp":1777447891509,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["20090237"],"award-info":[{"award-number":["20090237"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005423","name":"University Hospital of Uppsala","doi-asserted-by":"publisher","award":["110-2023"],"award-info":[{"award-number":["110-2023"]}],"id":[{"id":"10.13039\/501100005423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Heart failure (HF) is a disease often preceded by other cardiac disorders, such as myocardial infarction (MI) and atrial fibrillation (AF). We aimed to evaluate whether the plasma protein profiles of three groups of patients with incident HF\u2014HF with preceding MI, HF with preceding AF, and HF with no preceding MI or HF\u2014would be similar, and whether a common protein profile across all three HF groups could be detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data from 50 765 UK Biobank (UKB) participants with measurements on 2922 plasma proteins. Participants who developed HF after enrolment (12,6 years, median follow-up) were divided in those who, between enrolment and HF diagnosis, experienced a MI (MI-HF group, n = 269), developed AF (AF-HF, n = 519), or were not diagnosed with MI or AF (noMInoAF-HF, n = 1059). We estimate hazard ratios (HR) with 95% confidence interval (CI) for the associations between protein measurements and incident HF using multivariable adjusted Cox models. Proteins associated with the outcome across all three HF groups where further evaluated in relation to magnetic resonance-measured left ventricular ejection fraction (LV-EF) in 5097 UKB participants, and to echocardiography-measured diastolic E\/A-ratio in 502 POEM study participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After correction for multiple testing, 110 proteins were uniquely associated with HF in the noMInoAF-HF group, 21 proteins in the AF-HF group, and only one protein (ADGRG2) in the MI-HF group. Across all three HF groups, the same 60 proteins were significantly associated with HF, 13 of which were related to LV-EF and another 7 were associated with the E\/A-ratio. LRRN1 was inversely associated with incident HF in the MI-HF group [HR 0.49 (95% CI, 0.36, 0.67)], the AF-HF group [0.51 (0.41, 0.63)], and in the noMInoAF-HF group [0.58 (0.50, 0.68)]; all remaining proteins were positively associated with HF. ADM was the top association in the MI-HF group [HR 5.19 (3.06, 8.78)] and the AF-HF group [7.78 (5.31, 11.41)]. The most significant enriched pathways for the 60 shared proteins were interleukin-10 signalling, transcription of death receptors, and TNF receptor binding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A plasma protein profile associated with heart failure independently of prior MI or AF was identified. This protein profile represents several pathophysiological pathways of interest, and some of these proteins were also related to either LV-EF or the E\/A ratio. In addition, a number of proteins were found to be uniquely associated with only one of the three HF traits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag098","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:42:55Z","timestamp":1775734975000},"source":"Crossref","is-referenced-by-count":0,"title":["Plasma protein profiles in different heart failure phenotypes"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-8542","authenticated-orcid":false,"given":"Lars","family":"Lind","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Molecular Epidemiology, Uppsala University , Dag Hammarskj\u00f6lds v\u00e4g 14B, Uppsala 75185 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Delgado-Velandia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Molecular Epidemiology, Uppsala University , Dag Hammarskj\u00f6lds v\u00e4g 14B, Uppsala 75185 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"2026042808312158000_xvag098-B1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/s41588-024-02064-3","article-title":"Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes","volume":"57","author":"Henry","year":"2025","journal-title":"Nat Genet"},{"key":"2026042808312158000_xvag098-B2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/ejhf.980","article-title":"Circulating proteins as predictors of incident heart failure in the elderly","volume":"20","author":"Stenemo","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026042808312158000_xvag098-B3","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/s44161-024-00545-6","article-title":"Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank","volume":"3","author":"Lind","year":"2024","journal-title":"Nat Cardiovasc Res"},{"key":"2026042808312158000_xvag098-B4","doi-asserted-by":"publisher","first-page":"e002963","DOI":"10.1161\/CIRCGEN.120.002963","article-title":"Life-time covariation of Major cardiovascular diseases: a 40-year longitudinal study and genetic studies","volume":"14","author":"Lind","year":"2021","journal-title":"Circ Genom Precis Med"},{"key":"2026042808312158000_xvag098-B5","author":"UKBiobank"},{"key":"2026042808312158000_xvag098-B6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"2026042808312158000_xvag098-B7","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C-based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N Engl J Med"},{"key":"2026042808312158000_xvag098-B8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/ehjci\/jeaa297","article-title":"Cardiovascular magnetic resonance imaging in the UK Biobank: a major international health research resource","volume":"22","author":"Raisi-Estabragh","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026042808312158000_xvag098-B9","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/HJH.0000000000001863","article-title":"Proteomic profiling of endothelium-dependent vasodilation","volume":"37","author":"Lind","year":"2019","journal-title":"J Hypertens"},{"key":"2026042808312158000_xvag098-B10","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","article-title":"The reactome pathway knowledgebase 2024","volume":"52","author":"Milacic","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026042808312158000_xvag098-B11","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/s44161-024-00567-0","article-title":"Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced prediction","volume":"3","author":"Schuermans","year":"2024","journal-title":"Nat Cardiovasc Res"},{"key":"2026042808312158000_xvag098-B12","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","article-title":"IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR","volume":"104","author":"Krishnamurthy","year":"2009","journal-title":"Circ Res"},{"key":"2026042808312158000_xvag098-B13","doi-asserted-by":"publisher","first-page":"559220","DOI":"10.3389\/fphar.2020.559220","article-title":"Signaling via the interleukin-10 receptor attenuates cardiac hypertrophy in mice during pressure overload, but not isoproterenol infusion","volume":"11","author":"Stafford","year":"2020","journal-title":"Front Pharmacol"},{"key":"2026042808312158000_xvag098-B14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/cvr\/cvp040","article-title":"IL-10 attenuates TNF-alpha-induced NF kappaB pathway activation and cardiomyocyte apoptosis","volume":"82","author":"Dhingra","year":"2009","journal-title":"Cardiovasc Res"},{"key":"2026042808312158000_xvag098-B15","doi-asserted-by":"publisher","first-page":"e13768","DOI":"10.1111\/acel.13768","article-title":"DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice","volume":"22","author":"de Boer","year":"2023","journal-title":"Aging Cell"},{"key":"2026042808312158000_xvag098-B16","doi-asserted-by":"publisher","first-page":"e024582","DOI":"10.1161\/JAHA.121.024582","article-title":"p53-dependent mitochondrial compensation in heart failure with preserved ejection fraction","volume":"11","author":"Chen","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2026042808312158000_xvag098-B17","doi-asserted-by":"crossref","first-page":"e0170058","DOI":"10.1371\/journal.pone.0170058","article-title":"Growth hormone deficiency is associated with worse cardiac function. Physical performance, and outcome in chronic heart failure: insights from the T.O.S.CA. GHD study","volume":"12","author":"Arcopinto","year":"2017","journal-title":"PLoS One"},{"key":"2026042808312158000_xvag098-B18","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.jchf.2024.11.017","article-title":"Growth hormone replacement therapy in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial","volume":"13","author":"Marra","year":"2025","journal-title":"JACC Heart Fail"},{"key":"2026042808312158000_xvag098-B19","doi-asserted-by":"publisher","first-page":"D998","DOI":"10.1093\/nar\/gkae1070","article-title":"The NHGRI-EBI GWAS catalog: standards for reusability, sustainability and diversity","volume":"53","author":"Cerezo","year":"2025","journal-title":"Nucleic Acids Res"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/advance-article-pdf\/doi\/10.1093\/eschf\/xvag098\/68023247\/xvag098.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/2\/xvag098\/68023247\/xvag098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/2\/xvag098\/68023247\/xvag098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:36:07Z","timestamp":1777379767000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/doi\/10.1093\/eschf\/xvag098\/8650951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,10]]},"published-print":{"date-parts":[[2026,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/eschf\/xvag098","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,3]]},"article-number":"xvag098"}}