{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:31:08Z","timestamp":1782012668488,"version":"3.54.5"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"German Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The impact of coexisting left-sided valvular heart disease (VHD) on clinical outcomes following tricuspid valve edge-to-edge repair (T-TEER) for tricuspid regurgitation (TR) remains unclear, particularly under real-world conditions. To evaluate the prevalence and prognostic impact of concomitant left-sided VHD in patients undergoing T-TEER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included all patients undergoing T-TEER from the European Registry of Transcatheter Repair for Tricuspid Regurgitation (EuroTR; NCT06307262) with complete echocardiographic data on left-sided valve disease. Study endpoints included survival and heart failure hospitalizations (HFH) at 2 years, NYHA functional class, and TR reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among a total of 1647 eligible patients, 95.8%, 35.6%, and 3.8% had \u2265mild, moderate, and severe concomitant VHD, respectively. Moderate or higher VHD was associated with a significantly reduced 2-year survival (P &amp;lt; .001) and reduced 2-year HFH-free survival (P = .005). Multivariate regression analysis confirmed \u2265 moderate VHD to be an independent predictor of mortality (hazard ratio 1.54, 95% CI 1.21\u20131.96, P &amp;lt; .001). Despite worse TR and NYHA functional class at baseline in patients with \u2265moderate VHD, T-TEER was associated with a significant TR reduction (P &amp;lt; .001) and symptomatic improvement (P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Concomitant left-sided VHD is common among patients undergoing T-TEER and is independently associated with worse survival and higher rates of HFH. Nevertheless, T-TEER provides meaningful symptomatic benefit and durable TR reduction in patients with and without VHD burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag103","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:18:36Z","timestamp":1776511116000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of concomitant left-sided valve disease on outcomes following tricuspid valve transcatheter edge-to-edge repair: insights from EuroTR"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-6449","authenticated-orcid":false,"given":"Jonas","family":"Gmeiner","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, LMU Klinikum, LMU M\u00fcnchen , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Stolz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, LMU Klinikum, LMU M\u00fcnchen , Munich ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-6751","authenticated-orcid":false,"given":"Karl-Patrik","family":"Kresoja","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3871-164X","authenticated-orcid":false,"given":"Jennifer","family":"von Stein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Fortmeier","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology, Herz- und Diabeteszentrum NRW, Universit\u00e4tsklinik der Ruhr-Universit\u00e4t Bochum, Med. 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