{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:45:28Z","timestamp":1790912728184,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016262","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter therapies offer new treatment options for patients with both mitral regurgitation (MR) and tricuspid regurgitation (TR). However, the optimal treatment pathway in patients with combined MR and TR is not completely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This analysis evaluated the natural TR progression after mitral transcatheter edge-to-edge repair (MTEER) with the MitraClip System in patients with MR and TR from the EXPANDed studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EXPANDed is a pooled cohort from the EXPAND and EXPAND G4 studies. This study includes patients who had severe TR, achieved procedural success with MTEER, and received no direct TR intervention. Echocardiographic assessments were performed independently by echo core lab. Baseline characteristics, 1-year outcomes, and associations with TR improvement were reported based on 30-day TR severity following MTEER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of those with evaluable TR data at 30 days (N = 160), 73% (N = 116) improved to \u2264moderate TR, while 28% (N = 44) had \u2265severe TR. The \u2264moderate TR group had a lower prevalence of atrial fibrillation (68% vs 89%, P = .009), numerically lower LV ejection fraction (49% vs 56%, P = .07), and larger LV dimensions (LVEDV: 137.5 \u00b1 73.4 vs 107.9 \u00b1 44.8\u2005ml, P = .01). TR reduction was sustained in 86% of \u2264moderate TR patients, while 45% of \u2265severe TR patients improved to \u2264moderate at 1 year. In the \u2264moderate TR group, significant and larger improvements in NYHA functional class (P &amp;lt; .0001) and KCCQ-OS score (\u0394 = + 30.6 \u00b1 25.7, P &amp;lt; .0001) were observed through 1 year. One-year mortality was numerically lower in the \u2264moderate TR group (12.4% vs 22.3%) though not statistically significant (HR = 1.92 [.77, 4.79], P = .16). Lower LVEF and larger baseline LV size were associated with TR improvement post-MTEER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early TR improvement to \u2264moderate was observed in almost 3\/4 of the population and was associated with significant symptomatic relief. Patients with both severe MR and TR, particularly those with LV dilation, may experience TR improvement following MTEER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag108","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:34:47Z","timestamp":1776166487000},"source":"Crossref","is-referenced-by-count":1,"title":["Prognosis of tricuspid regurgitation after mitral transcatheter edge-to-edge repair: the EXPANDed studies"],"prefix":"10.1093","volume":"13","author":[{"given":"Rodrigo","family":"Estevez-Loureiro","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital \u00c1lvaro Cunqueiro , Estrada de Clara Campoamor, 341, Vigo, Pontevedra 36213 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Endeavor Health\/Northshore University Hospital , Chicago, IL 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M","family":"Asch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medstar Health Research Institute , Washington, DC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Ramon y Cajal ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody","family":"Dong","sequence":"additional","affiliation":[{"name":"Abbott Structural Heart , Santa Clara, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Peterman","sequence":"additional","affiliation":[{"name":"Abbott Structural Heart , Santa Clara, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelio","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St.Thomas , Nashville, TN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-5958","authenticated-orcid":false,"given":"Saibal","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Thousand Oaks , Los Robles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ospedale San Raffaele 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