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This clinical consensus statement provides a structured diagnostic and therapeutic approach based on two prognostic axes: the potential for LV reverse remodelling (LVRR) and the risk of sudden cardiac death (SCD). We operationalize four trajectories in the LV evolution, ranging from recovered LV ejection fraction (LVEF) to persistently reduced LVEF. Multimodal stratification including echocardiography, cardiac magnetic resonance, genetic profiling, biomarkers, and early treatment response allows tailored decision-making on pharmacological and device-based therapies. We propose a unified management algorithm emphasizing early initiation of guideline-directed medical therapy, structured reassessment at 3 and 6 months, and individualized consideration of defibrillators, resynchronization therapy, arrhythmia ablation, transcatheter valve leaflet edge-to-edge repair, and advanced heart failure assessment. This document aims to support clinicians in risk stratification and timely management or referrals.<\/jats:p>","DOI":"10.1093\/eschf\/xvag115","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T11:32:06Z","timestamp":1777203126000},"source":"Crossref","is-referenced-by-count":2,"title":["Evaluation and management of recent onset cardiomyopathy in the current era of heart failure therapeutics: a clinical consensus statement of the Heart Failure Association of the ESC"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0541-4926","authenticated-orcid":false,"given":"Hadi","family":"Skouri","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Balamand University , Beirut, Sinn El Fil , Beirut 55251 ,","place":["Lebanon"]},{"name":"Cardiology Division at Sheikh Shakhbout Medical City , P.O. Box 11001, Al MAfraq 00000, Abu Dhabi, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-1694","authenticated-orcid":false,"given":"Amr","family":"Abdin","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III-Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes , Kirrberger Street 100, 66421 Homburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-8590","authenticated-orcid":false,"given":"Wilfried","family":"Mullens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Genk ,","place":["Belgium"]},{"name":"Faculty of Medicine and Life Sciences, UHasselt, Biomedical Research Institute, LCRC , Diepenbeek ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bucciarelli Ducci","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Trust , London ,","place":["UK"]},{"name":"Faculty of Life Sciences and Medicine, School of Biomedical Engineering and Imaging Sciences, King\u2019s College University , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall C","family":"Starling","sequence":"additional","affiliation":[{"name":"Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-4413","authenticated-orcid":false,"given":"Peter","family":"Van der Meer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Savarese","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuvia","family":"ben Gal","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Rabin Medical Center , Petah Tikva ,","place":["Israel"]},{"name":"Gray Faculty of Medicine and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-197X","authenticated-orcid":false,"given":"Antoni","family":"Bayes-Genis","sequence":"additional","affiliation":[{"name":"Heart Institute, Hospital Universitari Germans Trias i Pujol, CIBERCV , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7803","authenticated-orcid":false,"given":"Stephane","family":"Heymans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University , Maastricht ,","place":["The Netherlands"]},{"name":"Centre of Cardiovascular Research, Centre for Molecular and Vascular Biology, University of Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[{"name":"Cardiopathology, Institute for Pathology, University Hospital T\u00fcbingen , T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-1202","authenticated-orcid":false,"given":"Sanjay K","family":"Prasad","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-3447","authenticated-orcid":false,"given":"Dimitrios","family":"Farmakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Athens University Hospital, National and Kapodistrian University of Athens School of Medicine , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-3628","authenticated-orcid":false,"given":"Ovidiu","family":"Chioncel","sequence":"additional","affiliation":[{"name":"Emergency Institute for Cardiovascular Diseases \u2018Prof. C.C. Iliescu\u2019, University of Medicine Carol Davila , Bucharest ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsen","family":"Ristic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade , Belgrade ,","place":["Serbia"]},{"name":"Department of Cardiology, University Clinical Centre of Serbia , Belgrade ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rosano","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Promotion of Quality of Life, San Raffaele Open University of Rome , Rome ,","place":["Italy"]},{"name":"Cardiology, San Raffaele Cassino Hospital , Cassino ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Seferovic","sequence":"additional","affiliation":[{"name":"University Faculty of Medicine, University of Belgrade, and Serbian Academy of Arts and Sciences , 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