{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:26:19Z","timestamp":1793114779922,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health, Rome, Italy","doi-asserted-by":"publisher","award":["RC 2017 R659\/17-CCM698"],"award-info":[{"award-number":["RC 2017 R659\/17-CCM698"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The left atrioventricular coupling index (LACI) has emerged as a potential prognostic marker in several clinical settings. This study evaluated the prognostic value of cardiac magnetic resonance (CMR)-derived LACI in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients from the multicentre DERIVATE registry with LVEF &amp;lt;50% who underwent CMR were included. LACI was calculated as the ratio between left atrial and left ventricular end-diastolic volumes. Univariable and multivariable Cox regression models estimated hazard ratios (HR) with 95% confidence intervals (CI) for predicting all-cause mortality (ACM), ACM or HF, and HF alone (competing-risk analysis). Time-dependent receiver operating characteristic analysis identified optimal cut-offs for 3-year outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2170 patients were included (mean age 59.8 \u00b1 13.9 years; 24.7% women; mean LVEF 31.6 \u00b1 11.3%). Median follow-up was 1016 days (580\u20131609). Median LACI was 19.4% (13.3\u201328.8). During follow-up, ACM occurred in 191 patients (8.8%), ACM or HF in 565 (26.0%), and HF in 442 (20.4%). After adjustment for clinical and CMR parameters, including LVEF and late gadolinium enhancement (LGE), each 5% increase in LACI was associated with higher risk of ACM (HR 1.06, 95% CI 1.01\u20131.11; P = .016), ACM or HF (HR 1.09, 95% CI 1.06\u20131.12; P &amp;lt; .001), and HF (HR 1.09, 95% CI 1.05\u20131.12; P &amp;lt; .001). The optimal cut-off for ACM was LACI \u226521% (AUC 0.617, 95% CI 0.561\u20130.673), identifying patients at higher risk of ACM, ACM or HF, and HF (log-rank P &amp;lt; .001 for all).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CMR-derived LACI independently predicts ACM and HF in patients with reduced LVEF and provides incremental prognostic value beyond LVEF and LGE. A cut-off of \u226521% identifies higher-risk patients and may support clinical risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag130","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:38:10Z","timestamp":1778585890000},"source":"Crossref","is-referenced-by-count":3,"title":["Cardiac magnetic resonance-derived left atrioventricular coupling index predicts outcome in reduced ejection fraction"],"prefix":"10.1093","volume":"13","author":[{"given":"Marco","family":"Guglielmo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht, The \u00a0","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Fedele","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Morgagni-Pierantoni University Hospital , Forl\u00ec ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-9717","authenticated-orcid":false,"given":"Luca","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Morgagni-Pierantoni University Hospital , Forl\u00ec ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7971-8052","authenticated-orcid":false,"given":"Matteo","family":"Armillotta","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Morgagni-Pierantoni University Hospital , Forl\u00ec ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Angeli","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Morgagni-Pierantoni University Hospital , Forl\u00ec ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariachiara","family":"Ciarlantini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna , Bologna ,","place":["Italy"]},{"name":"Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliera-Universitaria di Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Buccella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-675X","authenticated-orcid":false,"given":"Carmine","family":"Pizzi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Morgagni-Pierantoni University Hospital , Forl\u00ec ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Pezel","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Universit\u00e9 Paris Cit\u00e9, H\u00f4pital Lariboisi\u00e8re-Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Analysis Core Laboratory: Artificial Intelligence, University Hospital of Lariboisiere (AP-HP) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-915X","authenticated-orcid":false,"given":"Giovanni Donato","family":"Aquaro","sequence":"additional","affiliation":[{"name":"U.O.C. 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