{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:31Z","timestamp":1792785871045,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie","id":[{"id":"https:\/\/ror.org\/039w1jh10","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Cardiologie","id":[{"id":"https:\/\/ror.org\/03vqp1c86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"France 2030 program \u201cInitiative d'Excellence Lorraine\u201d","award":["ANR-15-IDEX-04-LUE"],"award-info":[{"award-number":["ANR-15-IDEX-04-LUE"]}]},{"name":"France 2030 ENACT AI Cluster","award":["ANR-23-IACL-0004"],"award-info":[{"award-number":["ANR-23-IACL-0004"]}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are leading causes of acute dyspnoea in the emergency department (ED) and frequently coexist. However, their combined impact on short- and long-term outcomes in the acute setting remains insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a monocentric observational study based on the PARADISE cohort, including patients admitted to the ED for acute dyspnoea between 2010 and 2019. Patients with a primary diagnosis of HF or COPD were included and stratified according to the presence of the alternate condition. The primary outcomes were in-hospital and post-discharge all-cause mortality, assessed using multivariable regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 5131 patients, 3543 had a primary diagnosis of HF and 1588 of COPD. Concomitant disease was present in approximately 20% of patients in both groups.<\/jats:p>\n                    <jats:p>In the primary HF cohort, patients with COPD had lower in-hospital mortality compared with those without COPD (8.5% vs. 11.7%, P = .014), but similar overall mortality (69.3% vs. 68.9%). After adjustment, COPD remained associated with lower in-hospital mortality (OR 0.74; 95% CI 0.55\u20130.99; P = .050) and with a modest increase in long-term mortality (HR 1.22; 95% CI 1.09\u20131.36; P &amp;lt; .001).<\/jats:p>\n                    <jats:p>In the primary COPD cohort, patients with HF had higher in-hospital mortality (7.4% vs. 3.4%, P = .001) and markedly higher long-term mortality (68.7% vs. 48.7%, P &amp;lt; .001). After adjustment, HF was not significantly associated with in-hospital mortality (OR 1.54; 95% CI 0.87\u20132.65; P = .13), but remained strongly associated with increased long-term mortality (HR 1.48; 95% CI 1.25\u20131.76; P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HF and COPD frequently coexist and are both associated with an increased long-term mortality risk, with a greater prognostic impact of HF in patients with COPD. These findings highlight the importance of systematic identification and optimized management of both conditions in this high-risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag136","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:45:48Z","timestamp":1779363948000},"source":"Crossref","is-referenced-by-count":1,"title":["Interplay between acute heart failure and COPD in patients hospitalized for dysponea: prognostic insights from the PARADISE cohort"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-2729","authenticated-orcid":false,"given":"Guillaume","family":"Baudry","sequence":"first","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]},{"name":"REICATRA, Recherche et Enseignement en IC Avanc\u00e9e, Transplantation, Assistance , Vand\u0153uvre-l\u00e8s-Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]},{"name":"Emergency Department, University Hospital of Nancy, INSERM U1116, University of Lorraine , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Monzo","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4520-4810","authenticated-orcid":false,"given":"Claire","family":"Lacomblez","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-3155","authenticated-orcid":false,"given":"Emmanuel","family":"Bresso","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Duarte","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e8ne","family":"Duchanois","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital of Nancy, INSERM U1116, University of Lorraine , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9borah","family":"Jaeger","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]},{"name":"Emergency Department, University Hospital of Nancy, INSERM U1116, University of Lorraine , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahar","family":"Chouihed","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]},{"name":"Emergency Department, University Hospital of Nancy, INSERM U1116, University of Lorraine , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[{"name":"CHRU de Nancy, Centre D'Investigation Clinique Plurith\u00e9matique 1433, INSERM, Universit\u00e9 de Lorraine, INSERM U116-DCAC, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) , 4 Rue du Morvan, Vand\u0153uvre-l\u00e8s-Nancy 54511 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"2026091805062864300_xvag136-B1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/acem.13118","article-title":"An observational study of Dyspnea in emergency departments: the Asia, Australia, and New Zealand Dyspnea in emergency departments study (AANZDEM)","volume":"24","author":"Kelly","year":"2017","journal-title":"Acad Emerg Med"},{"key":"2026091805062864300_xvag136-B2","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/ejhf\/xuaf027","article-title":"Short and long-term prognosis of hospitalization for dyspnoea based on aetiology and hospitalization ward: insights from the PARADISE cohort","volume":"28","author":"Baudry","year":"2026","journal-title":"Eur J Heart Fail"},{"key":"2026091805062864300_xvag136-B3","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1016\/S2213-2600(24)00413-2","article-title":"GOLD COPD report: 2025 update","volume":"13","author":"Venkatesan","year":"2025","journal-title":"Lancet Respir Med"},{"key":"2026091805062864300_xvag136-B4","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1183\/09031936.00128008","article-title":"Systemic manifestations and comorbidities of COPD","volume":"33","author":"Barnes","year":"2009","journal-title":"Eur Respir J"},{"key":"2026091805062864300_xvag136-B5","doi-asserted-by":"publisher","first-page":"4774","DOI":"10.3390\/jcm14134774","article-title":"The Complex relationship between heart failure and chronic obstructive pulmonary disease: a comprehensive review","volume":"14","author":"Corneanu","year":"2025","journal-title":"J Clin Med"},{"key":"2026091805062864300_xvag136-B6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cccn.2005.05.021","article-title":"Influence of renal function on NT-proBNP in patients admitted for dyspnoea in the emergency department: comparison with BNP","volume":"361","author":"Chenevier-Gobeaux","year":"2005","journal-title":"Clin Chim Acta"},{"key":"2026091805062864300_xvag136-B7","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2147\/COPD.S437899","article-title":"Lack of evidence regarding markers identifying acute heart failure in patients with COPD: an AI-supported systematic review","volume":"19","author":"van Dijk","year":"2024","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026091805062864300_xvag136-B8","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13402","article-title":"The impact of chronic obstructive pulmonary disease on hospitalization and mortality in patients with heart failure","volume":"51","author":"Xu","year":"2021","journal-title":"Eur J Clin Invest"},{"key":"2026091805062864300_xvag136-B9","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/ehf2.14958","article-title":"Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction","volume":"12","author":"Xu","year":"2025","journal-title":"ESC Heart Fail"},{"key":"2026091805062864300_xvag136-B10","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/ehf2.15127","article-title":"Phenotyping patients with chronic obstructive pulmonary disease and heart failure","volume":"12","author":"Becher","year":"2025","journal-title":"ESC Heart Fail"},{"key":"2026091805062864300_xvag136-B11","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1002\/ehf2.15264","article-title":"Atrial fibrillation development in the heart failure population from nationwide British linked electronic health records","volume":"12","author":"Yoshimura","year":"2025","journal-title":"ESC Heart Fail"},{"key":"2026091805062864300_xvag136-B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2024.107536","article-title":"Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction","volume":"223","author":"Lau","year":"2024","journal-title":"Respir Med"},{"key":"2026091805062864300_xvag136-B13","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019238","article-title":"Clinical characteristics and outcomes of patients with heart failure with reduced ejection fraction and COPD: insights from PARADIGM-HF","volume":"10","author":"Ehteshami-Afshar","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026091805062864300_xvag136-B14","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s11739-021-02879-6","article-title":"Head-to-head comparison of diagnostic scores for acute heart failure in the emergency department: results from the PARADISE cohort","volume":"17","author":"Chouihed","year":"2022","journal-title":"Intern Emerg Med"},{"key":"2026091805062864300_xvag136-B15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019557","article-title":"Hyponatraemia, hyperglycaemia and worsening renal function at first blood sample on emergency department admission as predictors of in-hospital death in patients with dyspnoea with suspected acute heart failure: retrospective observational analysis of the PARADISE cohort","volume":"8","author":"Chouihed","year":"2018","journal-title":"BMJ Open"},{"key":"2026091805062864300_xvag136-B16","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.ejheart.2006.01.010","article-title":"Heart failure and chronic obstructive pulmonary disease: an ignored combination?","volume":"8","author":"Rutten","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"2026091805062864300_xvag136-B17","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1136\/thoraxjnl-2020-216390","article-title":"Relationship between heart failure and the risk of acute exacerbation of COPD","volume":"76","author":"Axson","year":"2021","journal-title":"Thorax"},{"key":"2026091805062864300_xvag136-B18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ejim.2018.11.002","article-title":"Acutely decompensated heart failure with chronic obstructive pulmonary disease: clinical characteristics and long-term survival","volume":"60","author":"Scrutinio","year":"2019","journal-title":"Eur J Intern Med"},{"key":"2026091805062864300_xvag136-B19","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1378\/chest.14-0607","article-title":"Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the worcester heart failure study","volume":"147","author":"Fisher","year":"2015","journal-title":"Chest"},{"key":"2026091805062864300_xvag136-B20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1365-2796.2008.01975.x","article-title":"Chronic obstructive pulmonary disease in patients admitted with heart failure","volume":"264","author":"Iversen","year":"2008","journal-title":"In. J Intern Med. England"},{"key":"2026091805062864300_xvag136-B21","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/ehf2.14625","article-title":"The \u2018peptide for life\u2019 initiative in the emergency department study","volume":"11","author":"Bayes-Genis","year":"2024","journal-title":"ESC Heart Fail"},{"key":"2026091805062864300_xvag136-B22","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1002\/ejhf.3733","article-title":"Sex-based differences in heart failure management and outcomes: insights from the French-DataHF cohort","volume":"27","author":"Baudry","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"2026091805062864300_xvag136-B23","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/ejhf.3103","article-title":"Risk of readmission and death after hospitalization for worsening heart failure: role of post-discharge follow-up visits in a real-world study from the grand est region of France","volume":"26","author":"Baudry","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2026091805062864300_xvag136-B24","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1093\/eurheartj\/ehaf218","article-title":"Cardiologist follow-up and improved outcomes of heart failure: a French nationwide cohort","volume":"46","author":"Baudry","year":"2025","journal-title":"Eur Heart J"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/advance-article-pdf\/doi\/10.1093\/eschf\/xvag136\/68374658\/xvag136.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/5\/xvag136\/68374658\/xvag136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/5\/xvag136\/68374658\/xvag136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:06:37Z","timestamp":1789722397000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/doi\/10.1093\/eschf\/xvag136\/8691520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,23]]},"published-print":{"date-parts":[[2026,8,27]]}},"URL":"https:\/\/doi.org\/10.1093\/eschf\/xvag136","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,5,23]]},"article-number":"xvag136"}}