{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:51:18Z","timestamp":1790729478294,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention & Research Institute of Texas","doi-asserted-by":"publisher","award":["RP200381"],"award-info":[{"award-number":["RP200381"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute at the National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescents and young adults (AYAs) with sarcomas often receive high-dose doxorubicin (Dox), but data on early cardiotoxicity in this population are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To prospectively evaluate early echocardiographic changes in AYAs with sarcoma treated with high-dose Dox.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>AYAs (15\u201339 years) with sarcoma treated at a tertiary cancer centre (2018\u201322) were prospectively enroled. Echocardiograms were performed at baseline, 1 and 2 years after cancer therapy initiation and interpreted by a single cardiologist. The primary endpoint was a &amp;gt;10% absolute reduction in left ventricular ejection fraction (LVEF), an absolute LVEF &amp;lt;50%, or &amp;gt;10% decrease in LV wall thickness\/dimension (LVWT\/D) ratio from baseline. Secondary endpoints included longitudinal changes in cardiac structure, chamber volumes, systolic and diastolic function, and strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 70 patients, 56 completed at least two of three study echocardiograms (median age 22.6 [IQR, 17.6\u201330.5] years; 41% female, 84% white). Median cumulative Dox dose was 450 (IQR, 370\u2013450) mg\/m2; 75% received dexrazoxane. The primary endpoint was met by 44.4% at 1 year and 27.5% at 2 years, driven primarily by LVWT\/D ratio decline (37% at 1 year, 25% at 2 years), while significant LVEF decline was observed in 11.1% and 2.5%, respectively. Significant absolute changes at 1 year included LVEF (\u22122.73 \u00b1 4.3%, P &amp;lt; .001), global longitudinal strain magnitude (\u22121.37 \u00b1 2.56%, P = .002), septal e\u2032 (\u22121.75 \u00b1 2.48\u2005cm\/s, P &amp;lt; .001), and lateral e\u2032 (\u22122.78 \u00b1 3.44\u2005cm\/s, P &amp;lt; .001), persisting at 2 years. One patient (1.8%) developed ventricular fibrillation and heart failure with reduced ejection fraction, with LVEF recovery within 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over one-third of AYAs with sarcoma met the primary endpoint at 1 year, with half of these abnormalities persisting at 2 years, primarily driven by LVWT\/D ratio reductions. Subclinical changes in strain and diastolic function were observed, reflecting the broad cardiac impact of high-dose Dox in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag143","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:32:03Z","timestamp":1781613123000},"source":"Crossref","is-referenced-by-count":1,"title":["Early anthracycline cardiotoxicity in adolescents and young adults with sarcoma: a prospective echocardiographic study"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-6480","authenticated-orcid":false,"given":"Efstratios","family":"Koutroumpakis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center , 1515 Holcombe Blvd # 1451, Houston, TX 77030 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