{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:52:45Z","timestamp":1781895165010,"version":"3.54.5"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"German Heart Foundation","doi-asserted-by":"publisher","award":["F\/64\/24"],"award-info":[{"award-number":["F\/64\/24"]}],"id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Chair in Aging in the College of Health Sciences"},{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To quantify central oxygen delivery (O2D), peripheral oxygen extraction, and muscle diffusive oxygen conductance (DmO2) during upper-extremity resistance and lower-extremity aerobic exercise in patients with arrhythmogenic cardiomyopathy (ACM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Nineteen patients with ACM underwent invasive cardiopulmonary exercise testing with right heart and radial artery catheterization. Participants performed 1-min isometric handgrip (IM-HG) and bicep curl (BC) exercise at 70% maximal voluntary contraction, and 20- and 40-min supine cycling (CYC-20, CYC-40) at the first ventilatory threshold. Exercise pulmonary hypertension, defined by a cardiac output to mean pulmonary artery slope &amp;gt;3\u2005mmHg\/L\/min, did not occur (mean 0.67\u2005mmHg\/L\/min). Whole-body oxygen uptake (V\u0307O2) increased significantly across all modes (P &amp;lt; .001); however, central O2D did not increase significantly during IM-HG or BC and rose only modestly during cycling. In contrast, peripheral O2 extraction and DmO2 increased significantly across all modalities (P &amp;lt; .001). Dominance analysis revealed that DmO2 accounted for 77% of the variance in V\u0307O2 pooled across all conditions, whereas O2D accounted for only 23%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate-intensity isometric and dynamic resistance and aerobic exercise in ACM is mediated by a predominantly peripheral, rather than central, physiological stress in our small ACM sample. This may provide preliminary results for a physiological rationale for safe exercise in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag163","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:43:32Z","timestamp":1780573412000},"source":"Crossref","is-referenced-by-count":0,"title":["Oxygen utilization during moderate-intensity resistance and aerobic exercise in arrhythmogenic cardiomyopathy: the central role of the periphery"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6732-0939","authenticated-orcid":false,"given":"Simon","family":"Wernhart","sequence":"first","affiliation":[{"name":"Department for Preventive Sports Medicine and Sports Cardiology, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich (TUM) , Ismaningerstrasse 22, Munich 81675 ,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), partner 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