{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:47:59Z","timestamp":1783540079694,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"DigiCardiopaTh PhD program"},{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["87737205"],"award-info":[{"award-number":["87737205"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronotropic incompetence (CI) is a frequent but underappreciated feature of cardiac amyloidosis and may contribute to exercise intolerance. However, its prognostic significance remains incompletely defined. We investigated the prevalence, functional correlates, and prognostic value of chronotropic incompetence in patients with transthyretin amyloid cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicentre retrospective study, 212 stable outpatients with transthyretin amyloid cardiomyopathy, in sinus rhythm and na\u00efve to disease-specific therapy, underwent maximal cardiopulmonary exercise testing. Chronotropic response was assessed as peak heart rate expressed as a percentage of the age-predicted value (pHR%). Chronotropic incompetence prevalence was evaluated using clinically relevant thresholds. Prognostic performance for 1-year cardiovascular mortality was assessed using Cox regression, receiver operating characteristic analysis, and Kaplan\u2013Meier estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chronotropic incompetence defined by a pHR% \u226475% was present in 35% of patients and was associated with markedly impaired functional capacity, including lower peak oxygen uptake and reduced ventilatory efficiency. During 1-year follow-up, 10 cardiovascular deaths occurred. Among exercise-derived variables, pHR% demonstrated strong prognostic value, with each 1% increase associated with a 5.5% relative reduction in cardiovascular mortality risk (hazard ratio 0.945; P = .011). A pHR% threshold of 75% provided optimal discrimination (area under the curve 0.71) and identified a subgroup with significantly lower survival (log-rank P &amp;lt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A blunted chronotropic response is common in transthyretin amyloid cardiomyopathy and conveys adverse short-term prognosis. A pHR% \u226475% represents a clinically meaningful and easily obtainable threshold for functional and prognostic stratification, offering a pragmatic alternative when comprehensive cardiopulmonary exercise testing assessment is not available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag170","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:57:55Z","timestamp":1782921475000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of chronotropic incompetence in transthyretin cardiac amyloidosis: a multicentre study"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0614-2961","authenticated-orcid":false,"given":"Damiano","family":"Magr\u00ec","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, \u2018Sapienza\u2019 University of Rome , Via Giorgio Nicola Papanicolau, 00189 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Ermolaev","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Pisa ,","place":["Italy"]},{"name":"Division of Cardiology, Fondazione Toscana Gabriele Monasterio , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Willixhofer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-9950","authenticated-orcid":false,"given":"Antonello","family":"Maruotti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Khalifa University , Abu Dhabi ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-4906","authenticated-orcid":false,"given":"Sara","family":"Corradetti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, \u2018Sapienza\u2019 University of Rome , Via Giorgio Nicola Papanicolau, 00189 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Economia, Statistica e Finanza \u2018Giovanni Anania\u2019\u2014University of Calabria , Cosenza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Fu Ferrari","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Pisa ,","place":["Italy"]},{"name":"Division of Cardiology, Fondazione Toscana Gabriele Monasterio , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe D J","family":"Capelle","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-3710","authenticated-orcid":false,"given":"Christina","family":"Kronberger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-6006","authenticated-orcid":false,"given":"Giuseppe","family":"Vergaro","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Pisa ,","place":["Italy"]},{"name":"Division of Cardiology, Fondazione Toscana Gabriele Monasterio , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Passino","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Pisa ,","place":["Italy"]},{"name":"Division of Cardiology, Fondazione Toscana Gabriele Monasterio , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Salvioni","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-1691","authenticated-orcid":false,"given":"Irene","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Piotti","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Pisa ,","place":["Italy"]},{"name":"Division of Cardiology, Fondazione Toscana Gabriele Monasterio , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-5178","authenticated-orcid":false,"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, \u2018Sapienza\u2019 University of Rome , Via Giorgio Nicola Papanicolau, 00189 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-3867","authenticated-orcid":false,"given":"Piergiuseppe","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS , Milan ,","place":["Italy"]},{"name":"Department of Clinical Science and Community Medicine, University of Milan , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-8558","authenticated-orcid":false,"given":"Emiliano","family":"Fiori","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, \u2018Sapienza\u2019 University of Rome , Via Giorgio Nicola Papanicolau, 00189 Rome ,","place":["Italy"]},{"name":"Cardiovascular Center Aalst, AZORG , Moorselbaan 164, 9300 Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza Badr","family":"Eslam","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"2026070814312459400_xvag170-B1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/13506129.2024.2405948","article-title":"Amyloid nomenclature 2024: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee","volume":"31","author":"Buxbaum","year":"2024","journal-title":"Amyloid"},{"key":"2026070814312459400_xvag170-B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.122.010078","article-title":"Hemodynamic profiling and prognosis in cardiac amyloidosis","volume":"16","author":"Martens","year":"2023","journal-title":"Circ Heart Fail"},{"key":"2026070814312459400_xvag170-B3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf784.928","article-title":"Cardiac amyloidosis and heart failure phenotypes: a prognostic study of systolic function markers","volume":"46","author":"Zaroui","year":"2025","journal-title":"Eur Heart J"},{"key":"2026070814312459400_xvag170-B4","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1002\/ehf2.14621","article-title":"Invasive haemodynamics at rest and exercise in cardiac amyloidosis","volume":"11","author":"Holt","year":"2024","journal-title":"ESC Heart Fail"},{"key":"2026070814312459400_xvag170-B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2024.101232","article-title":"Impact of the noninvasive diagnostic algorithm on clinical presentation and prognosis in cardiac amyloidosis","volume":"3","author":"Tini","year":"2024","journal-title":"JACC Adv"},{"key":"2026070814312459400_xvag170-B6","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.jchf.2025.01.020","article-title":"Cardiopulmonary exercise testing with exercise echocardiography to assess treatment response in transthyretin amyloid cardiomyopathy","volume":"13","author":"Patel","year":"2025","journal-title":"JACC Heart Fail"},{"key":"2026070814312459400_xvag170-B7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/eurheartj\/ehaf667","article-title":"Transthyretin amyloid cardiomyopathy: from cause to novel treatments","volume":"47","author":"Fontana","year":"2025","journal-title":"Eur Heart J"},{"key":"2026070814312459400_xvag170-B8","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1002\/ehf2.15147","article-title":"Exercise limitations in amyloid cardiomyopathy assessed by cardiopulmonary exercise testing-A multicentre study","volume":"12","author":"Willixhofer","year":"2025","journal-title":"ESC Heart Fail"},{"key":"2026070814312459400_xvag170-B9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae666.957","article-title":"The added value of cardiopulmonary exercise testing in the diagnosis of heart failure with preserved ejection fraction","volume":"45","author":"Massa","year":"2024","journal-title":"Eur Heart J"},{"key":"2026070814312459400_xvag170-B10","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1174645","article-title":"The ventilatory component of the muscle metaboreflex is overstimulated in transthyretin cardiac amyloidosis patients with poor aerobic capacity","volume":"14","author":"Monfort","year":"2023","journal-title":"Front Physiol"},{"key":"2026070814312459400_xvag170-B11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/13506129.2018.1496077","article-title":"Peak VO2 is an independent predictor of survival in patients with cardiac amyloidosis","volume":"25","author":"Hein","year":"2018","journal-title":"Amyloid"},{"key":"2026070814312459400_xvag170-B12","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70308","article-title":"Ventilatory efficiency in cardiac amyloidosis\u2014A systematic review and meta-analysis","volume":"13","author":"Willixhofer","year":"2025","journal-title":"Physiol Rep"},{"key":"2026070814312459400_xvag170-B13","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/ejhf.2016","article-title":"Prognostic value of cardiopulmonary exercise testing in cardiac amyloidosis","volume":"23","author":"Nicol","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2026070814312459400_xvag170-B14","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1080\/13506129.2019.1582024","article-title":"Chronotropic incompetence and autonomic dysfunction as mechanisms of dyspnoea in patients with late stage cardiac amyloidosis","volume":"26","author":"Nativi-Nicolau","year":"2019","journal-title":"Amyloid"},{"key":"2026070814312459400_xvag170-B15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1001\/jamacardio.2024.0022","article-title":"Cardiopulmonary exercise testing in evaluating transthyretin amyloidosis","volume":"9","author":"Patel","year":"2024","journal-title":"JAMA Cardiol"},{"key":"2026070814312459400_xvag170-B16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1136\/heartjnl-2024-324607","article-title":"Prevalence and functional impact of chronotropic incompetence in amyloid cardiomyopathy: a multicentre analysis","volume":"111","author":"Magr\u00ec","year":"2025","journal-title":"Heart"},{"key":"2026070814312459400_xvag170-B17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.jacc.2025.09.004","article-title":"Transthyretin cardiac amyloidosis evaluation and management: 2025 ACC Concise Clinical Guidance","volume":"87","author":"Writing Committee","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"2026070814312459400_xvag170-B18","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1177\/2047487314551546","article-title":"Deceptive meaning of oxygen uptake measured at the anaerobic threshold in patients with systolic heart failure and atrial fibrillation","volume":"22","author":"Magr\u00ec","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"2026070814312459400_xvag170-B19","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/j.1755-5922.2010.00184.x","article-title":"Chronotropic incompetence and functional capacity in chronic heart failure: no role of \u03b2-blockers and \u03b2-blocker dose","volume":"30","author":"Magr\u00ec","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"2026070814312459400_xvag170-B20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.037290","article-title":"Chronotropic incompetence and cardiovascular outcomes in patients with heart failure with preserved ejection fraction","volume":"14","author":"Lin","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"2026070814312459400_xvag170-B21","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/13506129.2025.2547381","article-title":"Prognostic role of cardiopulmonary exercise testing in wild-type transthyretin amyloid cardiomyopathy patients treated with tafamidis","volume":"32","author":"Dalia","year":"2025","journal-title":"Amyloid"},{"key":"2026070814312459400_xvag170-B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006331","article-title":"Mechanisms of chronotropic incompetence in heart failure with preserved ejection fraction","volume":"13","author":"Sarma","year":"2020","journal-title":"Circ Heart Fail"},{"key":"2026070814312459400_xvag170-B23","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1093\/eurjpc\/zwae348","article-title":"Chronotropic incompetence across heart failure categories","volume":"32","author":"Magr\u00ec","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"2026070814312459400_xvag170-B24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1080\/13506129.2022.2043270","article-title":"Characteristics of patients with autonomic dysfunction in the Transthyretin Amyloidosis Outcomes Survey (THAOS)","volume":"29","author":"Barroso","year":"2022","journal-title":"Amyloid"},{"key":"2026070814312459400_xvag170-B25","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jaccao.2021.07.010","article-title":"Electrophysiological manifestations of cardiac amyloidosis","volume":"3","author":"Hartnett","year":"2021","journal-title":"JACC CardioOncol"},{"key":"2026070814312459400_xvag170-B26","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1002\/ejhf.3782","article-title":"Atrial cardiomyopathy: from healthy atria to atrial failure. A clinical consensus statement of the Heart Failure Association of the ESC","volume":"27","author":"Weerts","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"2026070814312459400_xvag170-B27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.tcm.2023.02.004","article-title":"Conduction system disease in cardiac amyloidosis","volume":"34","author":"Assaf","year":"2024","journal-title":"Trends Cardiovasc Med"},{"key":"2026070814312459400_xvag170-B28","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1002\/ejhf.2533","article-title":"Incidence and risk factors for pacemaker implantation in light-chain and transthyretin cardiac amyloidosis","volume":"24","author":"Porcari","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2026070814312459400_xvag170-B29","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1151803","article-title":"Risk stratification in transthyretin-related cardiac amyloidosis","volume":"10","author":"Scirpa","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2026070814312459400_xvag170-B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvdsp.2019.01.014","article-title":"Mode of death in cardiac amyloidosis","volume":"11","author":"Kharoubi","year":"2019","journal-title":"Arch Cardiovasc Dis Suppl"},{"key":"2026070814312459400_xvag170-B31","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.jacep.2020.04.020","article-title":"Cardiac implantable electronic devices: a window into the evolution of conduction disease in cardiac amyloidosis","volume":"6","author":"Rehorn","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"2026070814312459400_xvag170-B32","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1080\/13506129.2024.2414295","article-title":"Incidence and predictors of sudden death in patients with cardiac amyloidosis","volume":"31","author":"de Frutos","year":"2024","journal-title":"Amyloid"},{"key":"2026070814312459400_xvag170-B33","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1002\/ehf2.14406","article-title":"Cardiopulmonary exercise testing predicts prognosis in amyloid cardiomyopathy: a systematic review and meta-analysis","volume":"10","author":"Cantone","year":"2023","journal-title":"ESC Heart Fail"},{"key":"2026070814312459400_xvag170-B34","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.jacc.2016.06.033","article-title":"Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system","volume":"68","author":"Grogan","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2026070814312459400_xvag170-B35","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1016\/j.jacc.2021.08.073","article-title":"Effect of \u03b2-blocker withdrawal on functional capacity in heart failure and preserved ejection fraction","volume":"78","author":"Palau","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2026070814312459400_xvag170-B36","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.jacc.2025.09.1512","article-title":"Timing of mortality benefit in outcomes trials in transthyretin amyloidosis","volume":"87","author":"Claggett","year":"2026","journal-title":"J Am Coll Cardiol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eschf\/advance-article-pdf\/doi\/10.1093\/eschf\/xvag170\/68689449\/xvag170.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/4\/xvag170\/68689449\/xvag170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/13\/4\/xvag170\/68689449\/xvag170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:31:27Z","timestamp":1783535487000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/doi\/10.1093\/eschf\/xvag170\/8724014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,3]]},"published-print":{"date-parts":[[2026,7,4]]}},"URL":"https:\/\/doi.org\/10.1093\/eschf\/xvag170","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,3]]},"article-number":"xvag170"}}