{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:48:00Z","timestamp":1783540080137,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traditional cardiac resynchronization therapy (CRT) is an effective treatment for patients with heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study aimed to determine the long-term durability of CRT leads, factors predisposing to lead replacement, and the outcomes of lead replacement in CRT patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population comprised 1059 consecutive patients who received conventional CRT implants at a university hospital between 2002 and 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow-up of 1661 days (interquartile range: 815\u20132792), a total of 324 leads were replaced in 251 patients (23.7%) for non-infectious reasons. The overall crude incidence of lead replacement was 19.4 events per 1000 lead-years. Of those who required lead replacement, 126 subjects (50.2%) underwent the procedure within the first year after CRT implantation. Among patients followed for more than 10 years (n = 143; 13.5%), 67 subjects (46.8%) had one or more lead replacements. Duration of the index CRT procedure and fluoroscopy time were independent predictors of lead replacement in a multivariable analysis [hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.01\u20131.06, P = .02 and HR 1.11, 95% CI 1.02\u20131.15, P = .01, respectively]. The leads that required replacement were left ventricular (11.2%), right ventricular (10.8%), and right atrial (4%), corresponding to approximate rates of 21.4, 20.5, and 7.6 replacements per 1000 lead-years, respectively. Compared with no need for re-intervention, lead-related re-do procedures were not associated with overall long-term mortality (55.3% vs 51%, P = .3) or the incidence of device-related infective endocarditis (5.6% vs 4.5%, P = .82).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Almost 25% of patients with CRT require lead replacement during long-term follow-up for non-infectious reasons, and half of those require replacement within the first year. Over 10 years, nearly every second patient requires a lead-related redo procedure. Lead replacement was not associated with long-term all-cause mortality. Systematic proficiency-based training should be introduced as a routine strategy in the education of novice implanters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eschf\/xvag176","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:52:10Z","timestamp":1781869930000},"source":"Crossref","is-referenced-by-count":0,"title":["Lead replacement due to non-infectious reasons in patients with cardiac resynchronization therapy in long-term follow-up"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-0076","authenticated-orcid":false,"given":"Ewa","family":"J\u0119drzejczyk-Patej","sequence":"first","affiliation":[{"name":"1st Department of Cardiology and Angiology, Silesian Centre for Heart Diseases , Sk\u0142odowskiej-Curie 9, Zabrze 41-800 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