{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:04:52Z","timestamp":1793747092988,"version":"4.6.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["101136244 (TARGET)"],"award-info":[{"award-number":["101136244 (TARGET)"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD022\/0001"],"award-info":[{"award-number":["CD022\/0001"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD24\/0009\/0011"],"award-info":[{"award-number":["RD24\/0009\/0011"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Early recurrence (ER) after an acute stroke event (ASE; ischemic or hemorrhagic) in patients with atrial fibrillation (AF) presents a therapeutic challenge due to the need to balance ischemic prevention with hemorrhagic risk. This study aimed to quantify ER incidence, both ischemic and hemorrhagic, and identify its predictors using real-world data from a prospective registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Retrospective analysis of patients with AF, either known or detected within 6\u2009months, who were admitted for a first-ever ASE to a tertiary stroke center between 2005 and 2024. ER was defined as any recurrent event within 6\u2009months. Baseline characteristics, CHA2DS2-VASc score, CHADS-VA score, stroke severity, anticoagulation type, AF detection timing, and monitoring duration were recorded. Cox and Fine-Gray models identified independent predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1795 patients, 108 (6.0%) experienced ER. The cumulative incidence was 6.3% (95% CI 5.1\u20137.4), and most events occurred within the first 30\u2009days. Independent predictors included higher CHA2DS2-VASc score\u2009(sHR\u2009=\u20091.252, p\u2009=\u20090.023), lower initial stroke severity\u2009(sHR\u2009=\u20090.918, p\u2009&amp;lt;\u20090.001), concomitant stroke etiologies\u2009(sHR\u2009=\u20092.008, p\u2009=\u20090.001), and AF detected within 30\u2009days after stroke\u2009(sHR\u2009=\u20091.644, p\u2009=\u20090.026). DOAC use was protective\u2009(sHR\u2009=\u20090.484, p\u2009=\u20090.003), while VKA showed a non-significant trend\u2009(sHR\u2009=\u20090.637, p\u2009=\u20090.068). Interaction analysis showed increased recurrence risk only in non-anticoagulated patients with AF detected after stroke. These findings were consistent across sensitivity analyses restricted to ischemic stroke, incorporating time-dependent anticoagulation, or comparing CHADS-VA and CHA2DS2-VASc scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ER, predominantly ischemic, occurred mainly within 30\u2009days. Risk factors included AF detection timing, CHA2DS2-VASc score, stroke severity, concomitant causes, and anticoagulation status, supporting early risk stratification and DOAC initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/23969873251352397","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:01:37Z","timestamp":1768906897000},"source":"Crossref","is-referenced-by-count":1,"title":["Temporal patterns, incidence, and predictors of early stroke recurrence in atrial fibrillation"],"prefix":"10.1093","volume":"11","author":[{"given":"Daniel","family":"Guisado-Alonso","sequence":"first","affiliation":[{"name":"Neurology Department, Hospital del Mar Research Institute , Barcelona 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Hospital del Mar Research Institute , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vallverd\u00fa-Prats","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital del Mar Research Institute , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4393-5861","authenticated-orcid":false,"given":"Julia","family":"Peris-Subiza","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital del Mar Research Institute , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9120-7588","authenticated-orcid":false,"given":"Sergio","family":"Vidal-Notari","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital del Mar Research Institute , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3638-9953","authenticated-orcid":false,"given":"Laia","family":"Peraferrer-Montesinos","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital del Mar Research Institute , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Jim\u00e9nez-Conde","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital del Mar Research Institute , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Jim\u00e9nez-Balado","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital del Mar Research Institute , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Giralt-Steinhauer","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital 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