{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:25:41Z","timestamp":1791498341100,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001543","name":"Neurological Foundation of New Zealand","doi-asserted-by":"publisher","award":["2324 PRG"],"award-info":[{"award-number":["2324 PRG"]}],"id":[{"id":"10.13039\/501100001543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Non-invasive convective head cooling is a promising putative neuroprotective therapy for ischemic stroke patients as it may portably, non-invasively, and selectively cool the ischemic penumbra. We aimed to investigate the feasibility of utilizing non-invasive convective head cooling in ischemic stroke patients before and during endovascular thrombectomy (EVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We conducted a multi-center, prospective, non-randomized, open-label trial at two comprehensive stroke centers in ischemic stroke patients where EVT was planned. Patients were assessed for eligibility in the emergency department (ED) and had a cooling cap fitted that circulated coolant between \u22125\u00b0C and 0\u00b0C until EVT completion. The primary feasibility endpoint was adherence, defined as tolerating cooling for \u2a7e50% of the time from cooling cap application until EVT completion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between July and November 2024, 40 EVT patients (19 (47.5%) female, mean\u2009\u00b1\u2009SD age 71.6\u2009\u00b1\u200912.6\u2009years) underwent a median (IQR) duration of convective head cooling of 86 (58\u2013106)\u2009min. Thirty-nine (97.5%) participants met the primary feasibility endpoint. The enrollment rate was five participants per site per month. Median (IQR) time from comprehensive stroke center arrival to cooling start was 10 (5\u201351)\u2009min. Thirty-two (80%) patients received general anesthesia. eTICI 2b-3 reperfusion was achieved in 38 (95.0%) participants. Median (IQR) 24-h infarct volume was 14.3 (5.5\u201329.1)\u2009mL. Median (IQR) 3-month modified Rankin Scale score was 2 (1\u20135). Three-month mortality occurred in 8\/38 (21.1%) participants. Nine serious adverse events occurred in 8 (20.0%) participants, none of which were attributed to head cooling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Convective head cooling is feasible in patients undergoing EVT and warrants further investigation in larger randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/23969873251371001","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:01:53Z","timestamp":1768906913000},"source":"Crossref","is-referenced-by-count":2,"title":["Non-invasive convective head cooling during stroke thrombectomy: A prospective multi-center feasibility trial"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3808-4428","authenticated-orcid":false,"given":"William K","family":"Diprose","sequence":"first","affiliation":[{"name":"Department of Medicine , Faculty of Medical and Health Sciences, The University of Auckland, Auckland ,","place":["New Zealand"]},{"name":"Department of Neurology , John Hunter Hospital, Hunter New England Local Health District, New Lambton Heights, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Veilleux","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences , Cumming School of Medicine, University of Calgary, Calgary, AB ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Almekhlafi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences , Cumming School of Medicine, University of Calgary, Calgary, AB 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Medicine , Faculty of Medical and Health Sciences, The University of Auckland, Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Wiles","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine , Auckland City Hospital, Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine , Auckland City Hospital, Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-9023","authenticated-orcid":false,"given":"P Alan","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Medicine , Faculty of Medical and Health Sciences, The University of Auckland, Auckland ,","place":["New Zealand"]},{"name":"Department of 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