{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:20:21Z","timestamp":1772817621218,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Emergent intracranial stenting (EIS) is increasingly employed in the context of the acute ischaemic stroke treatment, but requires intraprocedural antiplatelet therapy (APT), which may raise haemorrhagic risk. This study aimed to evaluate the safety and effectiveness of different APT regimens during EIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This is a subanalysis of the RESISTANT registry, which is a multicenter retrospective registry of patients with acute ischaemic stroke treated with intracranial EIS between 2016 and 2023. Patients receiving intraprocedural antithrombotics were included. Primary efficacy outcomes were stent patency (intraprocedural and within 24\u00a0hours) and 3-month mRS. Secondary outcome was successful reperfusion (modified thrombolysis in cerebral infarction\u00a0\u2265\u00a02b), and the safety outcome was sICH. Multivariable and propensity score-matched analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 827 patients, 4 APT strategies were identified: single APT (n\u00a0=\u00a0102), oral dual antiplatelet therapy (dAPT) (Aspirin + Clopidogrel or Ticagrelor; n\u00a0=\u00a083), Cangrelor (n\u00a0=\u00a092) and GP IIb\/IIIa inhibitors (GPi) (n\u00a0=\u00a0550). Intravenous agents (Cangrelor\/GPi) showed a trend towards lower risk of intraprocedural stent occlusion compared to oral dAPT (adjusted odds ratio [aOR] 0.30, [95% CI, 0.09\u20131.01], P\u00a0=\u00a0.053), though this did not reach statistical significance. GP IIb\/IIIa inhibitors continued to demonstrate a protective trend at 24\u00a0hours (aOR 0.25, [95% CI, 0.06\u20130.99], P\u00a0=\u00a0.047), without a significant increase in sICH. Both intravenous agents were independently associated with higher odds of successful final reperfusion (odds ratio [OR] 4.35, [95% CI, 1.57\u201312.09], P\u00a0=\u00a0.001). No significant differences emerged between GPi and Cangrelor in matched analysis. No significant difference was observed on good functional outcome between APT strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the setting of EIS, intravenous APT agents (Cangrelor or GPi) were associated with improved stent patency and higher rates of successful reperfusion, without a significant increase in symptomatic haemorrhage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakaf005","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:02:38Z","timestamp":1768906958000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of intraprocedural antiplatelet therapy on stent patency and safety after emergent intracranial stenting in acute ischaemic stroke: insights from the RESISTANT registry"],"prefix":"10.1093","volume":"11","author":[{"given":"Francesco","family":"Diana","sequence":"first","affiliation":[{"name":"Interventional Neuroradiology, Vall d'Hebron University Hospital , Barcelona ,","place":["Spain"]},{"name":"Vall d\u2019Hebron Research Institute , Barcelona ,","place":["Spain"]},{"name":"Department of Life Sciences, Health and Health Professions, Link Campus University , Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameer E","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Valley Baptist Medical Center , Harlingen, TX ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Ortega-Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa , Iowa City, IA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology, Valley Baptist Medical Center , Harlingen, TX ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Rodriguez-Calienes","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa , Iowa City, IA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Olive Gadea","sequence":"additional","affiliation":[{"name":"Stroke Unit, Vall d'Hebron University Hospital , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kaesmacher","sequence":"additional","affiliation":[{"name":"University Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Inselspital , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Mujanovic","sequence":"additional","affiliation":[{"name":"University Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Inselspital , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Geyik","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Ayd\u0131n University , IAU Stroke Center, Istanbul ,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songul","family":"Senadim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Ayd\u0131n University , IAU Stroke Center, Istanbul ,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Piano","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amedeo","family":"Cervo","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Salcuni","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Moreu","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Unit, Department of Radiology, Hospital Cl\u00ednico Universitario San Carlos , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"L\u00f3pez-Fr\u00edas","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Unit, Department of 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,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Amorim","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Hospital de Braga , Braga ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torcato","family":"Meira","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Hospital de Braga , Braga ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Renieri","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Department, Careggi University Hospital , Florence ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Capasso","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Department, Careggi University Hospital , Florence ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele G","family":"Romano","sequence":"additional","affiliation":[{"name":"Neuroradiology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona' , Salerno ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Barcena","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitario 12 de Octubre , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Seoane","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario 12 de Octubre , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Abdalkader","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine , Boston, MA 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, Rome,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ricchetti","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Interventional Neuroradiology, Policlinico Umberto I, Sapienza University of Rome , Rome,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Faculty of Medicine University of Porto , Porto ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o , Porto ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan H","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, NY ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Jaikumar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, NY ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Navia","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology, La Paz University Hospital, Hospital La Paz Institute for Health Research-IdiPAZ , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Ntoulias","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Hospital 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