{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:25:57Z","timestamp":1769088357585,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2019T060"],"award-info":[{"award-number":["2019T060"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2012T077"],"award-info":[{"award-number":["2012T077"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["CVON2015-01: CONTRAST"],"award-info":[{"award-number":["CVON2015-01: CONTRAST"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001826","name":"The Netherlands Organisation for Health Research and Development","doi-asserted-by":"crossref","award":["ASPASIA"],"award-info":[{"award-number":["ASPASIA"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zon Mw","award":["015008048"],"award-info":[{"award-number":["015008048"]}]},{"name":"Brain Foundation Netherlands","award":["HA2015.01.06"],"award-info":[{"award-number":["HA2015.01.06"]}]},{"DOI":"10.13039\/501100004725","name":"Ministry of Economic Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In patients with intracerebral haemorrhage (ICH), perihaematomal oedema (PHO) is considered a marker of secondary injury and is associated with worse functional outcomes. Minimally invasive surgery (MIS) has been suggested to reduce PHO when performed within 72\u00a0h of symptom onset. However, the effect of early surgery on PHO formation remains unclear. We aimed to determine the effect of MIS within 8\u00a0h of ICH onset on PHO formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We included patients with spontaneous, supratentorial ICH \u226510\u00a0mL undergoing MIS within 8\u00a0h from the DIST-pilot study and compared them to patients receiving standard care from a cohort study. ICH and PHO volumes at baseline and 24(\u00b112) h were manually segmented. The primary outcome was absolute PHO (aPHO) volume at 24\u00a0h. Secondary outcomes included aPHO growth between baseline, and 24\u00a0h and oedema extension distance (OED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 34 patients (median age 61\u00a0years, 68% male) undergoing MIS and 16 patients (median age 65\u00a0years, 69% male) receiving standard medical care. At baseline, median ICH, aPHO and OED volume were similar between groups. Median aPHO volume at 24\u00a0h was similar between groups (median difference \u22123.0\u00a0mL, 95% CI, \u221219.4 to 9.8, P\u00a0=.67), while median aPHO growth was smaller in the MIS-group (median difference \u22126.8\u00a0mL, 95% CI, \u221218.67 to 0.33, P\u00a0=.002). Median OED was greater in the MIS-group (median difference 0.18\u00a0cm, 95% CI, 0.05\u20130.40, P\u00a0=.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Absolute PHO growth in the first 24\u00a0h after ICH was less pronounced after early MIS than after standard care, suggesting that early MIS may ameliorate secondary injury after ICH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakaf025","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:02:34Z","timestamp":1768906954000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of minimally invasive intracerebral haematoma evacuation on early perihaematomal oedema formation"],"prefix":"10.1093","volume":"11","author":[{"given":"Maaike P","family":"Cliteur","sequence":"first","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte","family":"Sondag","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoert A H","family":"Pegge","sequence":"additional","affiliation":[{"name":"Department of Radiology, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilmar M T","family":"Jolink","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University , Utrecht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Verbaan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Amsterdam University Medical Center, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hieronymus D","family":"Boogaarts","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke J H","family":"Wermer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center , Leiden,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-0644","authenticated-orcid":false,"given":"Ruben","family":"Dammers","sequence":"additional","affiliation":[{"name":"Department 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