{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:12:24Z","timestamp":1771351944292,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"SNSF","doi-asserted-by":"publisher","award":["33IC30_179667"],"award-info":[{"award-number":["33IC30_179667"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Post-stroke depression (PSD) frequently occurs after acute stroke and negatively affects rehabilitation. Dopamine has beneficial effects on motivation and emotional stability. In stroke patients, low dopamine levels are linked to PSD. This study investigated whether levodopa treatment during in-hospital rehabilitation impacts PSD compared to placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>ESTREL-Depression was a pre-planned analysis of the multicenter, randomized, double-blind, placebo-controlled ESTREL trial. Participants with an acute ischemic or hemorrhagic stroke were randomly assigned to receive either levodopa\/carbidopa (100\/25\u00a0mg) or placebo three times daily for 39\u00a0days. All ESTREL participants with (1) information about the presence or absence of depression at three months and (2) who took at least 80% of the study medication were eligible for the study. Participants with a history of depression were excluded. For the primary outcome, the presence of PSD was defined as having a T-score of \u226555 in the Patient-Reported Outcomes Measurement Information System short-form depression-4a 3 months after randomization. Binary logistic regression was performed to assess the effect of levodopa on PSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 407 ESTREL participants (median age 72, 60% male), 209 receiving levodopa, and 198 receiving placebo. At 3 months, the frequency and odds of PSD did not differ between the levodopa group (26%) and the placebo group (28%) (OR\u00a0=\u00a00.93, 95% CI, 0.60\u20131.43).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the ESTREL-Depression study, treatment with levodopa had no impact on the occurrence of PSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov: NCT03735901 (https:\/\/clinicaltrials.gov\/study\/NCT03735901).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag001","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:37:51Z","timestamp":1771349871000},"source":"Crossref","is-referenced-by-count":0,"title":["The impact of levodopa on post-stroke depression: the ESTREL-depression-study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5598-6249","authenticated-orcid":false,"given":"Mirjam I","family":"Sauter","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Neurology, University Department of Geriatric Medicine FELIX PLATTER, University of Basel , Basel ,","place":["Switzerland"]},{"name":"Department of Neurology and Stroke Center, Department of Clinical Research, University Hospital Basel and University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-2796","authenticated-orcid":false,"given":"Josefin E","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Neurology, University Department of Geriatric Medicine FELIX PLATTER, University of Basel , Basel ,","place":["Switzerland"]},{"name":"Department of Neurology and Stroke Center, Department of Clinical Research, University Hospital Basel and University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2383-881X","authenticated-orcid":false,"given":"Lukas","family":"Boos","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Neurology, University Department of Geriatric Medicine FELIX PLATTER, University of Basel , Basel ,","place":["Switzerland"]},{"name":"Department of Neurology and Stroke Center, Department of Clinical Research, University Hospital Basel and University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-2497","authenticated-orcid":false,"given":"Annaelle","family":"Zietz","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Neurology, University Department of Geriatric Medicine FELIX PLATTER, University of Basel , Basel ,","place":["Switzerland"]},{"name":"Department of Neurology and Stroke Center, Department of Clinical Research, University Hospital Basel and University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2537-855X","authenticated-orcid":false,"given":"Simon","family":"Tr\u00fcssel","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Neurology, University Department of Geriatric Medicine FELIX PLATTER, University of Basel , Basel ,","place":["Switzerland"]},{"name":"Department of Neurology and Stroke Center, Department of Clinical Research, University Hospital Basel and University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-7382","authenticated-orcid":false,"given":"Andreas R","family":"Luft","sequence":"additional","affiliation":[{"name":"Division of 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