{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:15:59Z","timestamp":1772208959763,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012028","name":"Netherlands Thrombosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Anaemia is an established risk factor for poor outcome in intracerebral haemorrhage and ischaemic stroke. We examined whether anaemia predicts poor outcome in cerebral venous thrombosis (CVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We used data of the DOAC-CVT study, which was an international, prospective observational cohort study in adult patients with CVT that ran from January 2021 to January 2024. Anaemia at admission was defined according to World Health Organization criteria. Poor outcome was defined as modified Rankin Scale (mRS) 3\u20136 at 6-months. Binary logistic regression, adjusted for age, recent delivery\/puerperium, income country, cancer and intracranial haemorrhage, was applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 619 patients in DOAC-CVT, 583 patients were included, of whom 157 (27%) had anaemia. Compared to patients without anaemia, patients with anaemia were slightly younger (median age 40 vs. 42\u00a0years), more often female (76% vs. 59%), from middle income countries (36% vs. 21%), more often had intracranial haemorrhage (48% vs. 32%) and cancer (5% vs. 2%). Anaemia was associated with poor functional outcome (mRS 3\u20136, 10% vs. 5%, aOR: 2.20, 95% Cl, 1.01\u20134.81), but not with mortality (3% vs. 1%, aOR: 3.54, 95% Cl, 0.68\u201318.31). When stratified by severity, moderate to severe anaemia was associated with poor functional outcome (aOR 2.88, 95% Cl, 1.14\u20137.38), but mild anaemia was not (aOR 1.64, 95% Cl, 0.60\u20134.55).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>Anaemia at admission, especially moderate to severe, is a predictor for poor functional outcome in patients with CVT, highlighting the need for further studies on potential interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag006","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:50:36Z","timestamp":1772207436000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of anaemia severity on functional outcome in patients with cerebral venous thrombosis: a DOAC-CVT substudy"],"prefix":"10.1093","volume":"11","author":[{"given":"Nada M","family":"Sobih","sequence":"first","affiliation":[{"name":"Department of Neurology, Amsterdam UMC, location University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6312-1160","authenticated-orcid":false,"given":"Jelle","family":"Vellema","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam UMC, location University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"van de Munckhof","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam UMC, location University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayte Sanchez","family":"van Kammen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam UMC, location University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-2852","authenticated-orcid":false,"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ido","family":"van den Wijngaard","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haaglanden Medical Center , The Hague ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Molad","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tel Aviv Sourasky Medical center , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Zedde","sequence":"additional","affiliation":[{"name":"Department of neurology, Azienda Unita Sanitaria Locale di Reggio Emilia , Reggio Emilia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y Muralidhar","family":"Reddy","sequence":"additional","affiliation":[{"name":"CARE Institute of Neurological Sciences, CARE Hospital , Banjara Hills, Hyderabad ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Wasay","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aga Khan University , Karachi ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Arauz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto Nacional de Neurologia y Neurocirug\u00eda Manuel Velasco Suarez , Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Heldner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, University Hospital and University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Ergin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, Pamukkale University , Denizli ,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A","family":"Barboza","sequence":"additional","affiliation":[{"name":"Neurosciences Department, Hospital Dr. Rafael A. Calder\u00f3n Guardia , San Jos\u00e9 ,","place":["Costa Rica"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Aguiar","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Stroke Center, Centro Hospitalar Universit\u00e1rio de Lisboa Central \u2013 ULS S\u00e3o Jos\u00e9, CEEM and Institute of Anatomy, Faculdade de Medicina da Universidade de Lisboa, Gulbenkian Institute of Molecular Medicine , Lisbon ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8746-1771","authenticated-orcid":false,"given":"Katarina","family":"Jood","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sahlgrenska University Hospital , Gothenburg ,","place":["Sweden"]},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg , Gothenburg 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