{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:19:53Z","timestamp":1772209193711,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["201500881"],"award-info":[{"award-number":["201500881"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A recent meta-analysis, including the TIMING study, found favourable short-term outcomes after early initiation of a direct-acting oral anticoagulant (DOAC), as compared to delayed initiation, following acute ischaemic stroke in patients with atrial fibrillation. We aimed to investigate 1-year outcomes after early vs delayed DOAC initiation in the TIMING study population and a concurrent observational cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>In TIMING, adults with atrial fibrillation were randomised to initiation of DOAC either within 4\u00a0days or at 5\u201310\u00a0days after acute ischaemic stroke. The non-randomised cohort comprised patients with acute ischaemic stroke and atrial fibrillation, observed in the Swedish Stroke Register concurrently with the TIMING study and initiating DOAC within 4 or 5\u201310\u00a0days, respectively. Outcomes in both populations were acute ischaemic stroke, symptomatic intracerebral haemorrhage or death, as a composite and individually, analysed using Cox regression models, with adjustment for risk factors in the observational cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the TIMING population (n\u00a0=\u00a0888), the composite outcome at 365\u00a0days occurred in 64\/450 patients (14.2%) with early DOAC initiation and 66\/438 (15.1%) with delayed, unadjusted hazard ratio 0.92 (95% CI, 0.66\u20131.30). In the observational cohort (n\u00a0=\u00a08951), the composite outcome at 365\u00a0days occurred in 1227\/6671 (18.4%) patients initiating DOAC early and 511\/2280 (22.4%) in the delayed group, adjusted hazard ratio 0.80 (0.69\u20130.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>At 1-year follow-up, early initiation of DOAC remained safe and effective with no increase in symptomatic intracerebral haemorrhage. The results support early DOAC initiation in patients with acute ischaemic stroke and atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag010","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:50:45Z","timestamp":1772207445000},"source":"Crossref","is-referenced-by-count":0,"title":["Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-4037","authenticated-orcid":false,"given":"Oskar","family":"Fasth","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Uppsala University , Uppsala 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