{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:04:23Z","timestamp":1779721463208,"version":"3.53.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Science Fund for Distinguished Young Scholars of China","award":["82425021"],"award-info":[{"award-number":["82425021"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0527905"],"award-info":[{"award-number":["2024ZD0527905"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271349"],"award-info":[{"award-number":["82271349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China","award":["KFKT202506"],"award-info":[{"award-number":["KFKT202506"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Procedure time (PT) during endovascular thrombectomy (EVT) may be associated with clinical outcomes in acute ischaemic stroke (AIS). We evaluated the association between PT and clinical outcomes using a large pooled analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We performed a post hoc analysis of 3 multicentre randomised controlled trials including patients with anterior circulation large-vessel occlusion treated with EVT in China (2018\u20132023). The primary outcome was a favourable outcome (mRS, 0\u20132) at 90\u00a0days; the secondary outcomes were excellent outcome (mRS 0\u20131), sICH and all-cause mortality. Procedure time was evaluated as a continuous variable (per 10-min increase) and in categories (\u226460, 60\u2013120, &amp;gt;\u2009120\u00a0min) using adjusted logistic and mixed-effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2845 eligible patients (median age 68\u00a0years, 57.4% were male, median PT 69\u00a0min), each 10-min increase in PT was associated with an adjusted risk difference (aRD) of \u22121.52% (95% CI, \u22121.85% to \u22121.20%) in the probability of achieving mRS 0\u20132 and an aRD of 0.77% (95% CI, 0.53%\u20131.01%) increase in mortality, corresponding to lower odds of mRS 0\u20132 (aOR 0.928; 95% CI, 0.912\u20130.944) and higher odds of sICH (aOR 1.028; 95% CI, 1.007\u20131.049) and mortality (aOR 1.055; 95% CI, 1.037\u20131.073). Compared with PT\u00a0\u2264\u00a060\u00a0min, PT 60\u2013120 and\u00a0&amp;gt;\u00a0120\u00a0min were associated with reduced odds of mRS 0\u20132 (aOR 0.658 and 0.355, respectively) and increased mortality (aOR 1.648 and 2.422, respectively). These associations were consistent across sensitivity analyses. In exploratory mediation analyses, total passes and the first pass effect (FPE) explained only 12.9% and 11.4% of the association between PT and favourable outcome, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion<\/jats:title>\n                    <jats:p>Prolonged PT during EVT was associated with a reduced rate of favourable outcomes and increased sICH and mortality. These findings support continued efforts to minimise avoidable intraprocedural delays during EVT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag048","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:36:49Z","timestamp":1779719809000},"source":"Crossref","is-referenced-by-count":0,"title":["Procedure time and clinical outcomes after thrombectomy: a pooled cohort analysis of three randomised trials"],"prefix":"10.1093","volume":"11","author":[{"given":"Xuanyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , No.183 Xinqiao Main Street, Shapingba District, Chongqing 400037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second 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Support Force , No. 1028 Jinggangshan Avenue, Qingyunpu District, Nanchang, Jiangxi 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , No.183 Xinqiao Main Street, Shapingba District, Chongqing 400037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , No.183 Xinqiao Main Street, Shapingba District, Chongqing 400037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, 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