{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:13:35Z","timestamp":1783527215905,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["397530000"],"award-info":[{"award-number":["397530000"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Research Board Ireland"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["397530000"],"award-info":[{"award-number":["397530000"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FWO\u2014Fonds Wetenschappelijk Onderzoek Vlaanderen (Research Foundation Flanders), Belgium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertension is a major modifiable risk factor for stroke. Studies between 1996 and 2013 reported high rates of non-achievement of guideline recommended blood pressure (BP) targets following stroke\/TIA. Few recent large studies of long-term post-stroke BP management exist, and no studies have reported findings since the introduction of new guideline recommendations (systolic blood pressure [SBP]\u00a0&amp;lt;\u00a0130\u00a0mmHg) in 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We analysed BP control in the CONVINCE trial, which randomised 3154 recent ischaemic stroke\/high-risk TIA patients to colchicine 0.5\u00a0mg daily or usual care. Clinic BP was measured at 6-monthly trial visits from 2017 to 2024. We calculated mean follow-up BP using all available follow-up BP measurements, and examined factors associated with non-achievement of pre-2022 guideline BP targets by multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 3144 randomised consenting patients, at least 1 follow-up BP reading was available for 2920. There were high rates of antiplatelet medication (97.6%) and statin (94.1%) usage. Mean SBP during follow-up was 136.6\u00a0mmHg (SD 12.8), mean diastolic BP was 79.3\u00a0mmHg (SD 7.8). A total of 36% of participants had mean SBP \u2265 140\u00a0mmHg and failed to meet pre-2022 guideline targets, while 70% had mean SBP\u00a0\u2265\u00a0130\u00a0mmHg, not achieving current guideline targets. On multivariable logistic regression, increased age (OR: 1.026 per year increase; 95% CI, 1.018\u20131.034), history of hypertension (OR: 1.47; 95% CI, 1.24\u20131.74) and lacunar stroke subtype (OR: 1.26; 95% CI, 1.06\u20131.49) were independently associated with guideline non-achievement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion<\/jats:title>\n                    <jats:p>In a large contemporary secondary stroke prevention trial, over one-third of participants did not achieve less-stringent pre-2022 BP guideline targets, and 70% did not achieve current ESO guideline targets. New approaches are needed to improve guideline implementation in practice.<\/jats:p>\n                    <jats:p>Trial Registration: ClinicalTrials.gov (NCT02898610).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag051","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:16:12Z","timestamp":1783523772000},"source":"Crossref","is-referenced-by-count":0,"title":["Contemporary achievement of guideline recommendations for blood pressure management after stroke in the CONVINCE trial"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1398-8754","authenticated-orcid":false,"given":"P\u00e1draig","family":"Synnott","sequence":"first","affiliation":[{"name":"Health Research Board (HRB) Stroke Clinical Trials Network Ireland (SCTNI), UCD Clinical Research Centre , Nelson Street, Dublin ,","place":["Ireland"]},{"name":"School of Medicine, University College Dublin (UCD) , Dublin 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