{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:48:04Z","timestamp":1782820084540,"version":"3.54.5"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Funds for the Innovation of Science and Technology of Fujian Province","award":["2021Y9131"],"award-info":[{"award-number":["2021Y9131"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20296"],"award-info":[{"award-number":["U22A20296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Procedure time during endovascular thrombectomy (EVT) has been associated with outcomes in general thrombectomy cohorts, but whether this relationship reflects a threshold or continuous risk accumulation in large-core stroke remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We performed a retrospective observational analysis of 490 patients with anterior-circulation large-vessel occlusion (LVO) and large-core infarction, defined by an Alberta Stroke Program Early Computed Tomography Score of 5 or less, from a prospective multicentre registry across 38 centres. Procedure time was analysed categorically and continuously. The primary outcome was the 90-day mRS score of 0\u20133. Secondary outcomes were 90-day mortality and sICH. Restricted cubic splines tested nonlinearity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Each 10-min increase in procedure time was associated with lower odds of an modified Rankin Scale (mRS) score of 0\u20133 (odds ratio, 0.91; 95% CI, 0.86\u20130.95) and higher mortality (odds ratio, 1.07; 95% CI, 1.02\u20131.11). On the absolute scale, the marginally standardised probability of mRS 0\u20133 decreased from 44.5% at 60\u00a0min to 27.5% at 150\u00a0min (absolute risk difference\u00a0\u2212\u00a017.1 percentage points; 95% CI,\u00a0\u2212\u00a027.7 to \u22126.4). Spline analyses showed no evidence of nonlinearity for functional outcome or mortality. No consistent association with sICH was observed across analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Longer procedure time was associated with progressively worse functional outcome and higher mortality in large-core EVT, without evidence of a clear nonlinear inflection point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support procedure time as a continuous intraprocedural risk indicator that may inform ongoing procedural reassessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>MAGIC registry, ChiCTR.org.cn Identifier: ChiCTR2100051664.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag062","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:36:25Z","timestamp":1782495385000},"source":"Crossref","is-referenced-by-count":0,"title":["Procedure time and 90-day outcomes after endovascular thrombectomy for large-core stroke"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-0224","authenticated-orcid":false,"given":"Chengsong","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Neurology and Institute of Neurology of The First Affiliated Hospital, Institute of Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University , Fuzhou, Fujian 350005 ,","place":["China"]},{"name":"Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian 350212 ,","place":["China"]},{"name":"Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University , Fuzhou 350004 ,","place":["China"]},{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongzong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, No. 924 Hospital of Joint Logistic Support Force of Chinese PLA , Guangxi 541002 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University) , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third 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