{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:46:14Z","timestamp":1782819974595,"version":"3.54.5"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health"},{"name":"Care Research University College London Hospitals Biomedical Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adverse non-motor outcomes dominate the lived reality of post-stroke recovery, yet remain poorly understood after intravenous thrombolysis (IVT), endovascular thrombectomy (EVT) or both. We characterised the prevalence of outcomes in 13 non-motor domains, stratified by mRS scores, and identified baseline factors associated with adverse outcomes at 6 months follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective observational sub-study within the Stroke Investigation Group in North and Central London (SIGNAL) registry to characterise non-motor outcomes after IVT, EVT or both. At 6\u00a0months, we assessed mRS alongside 13 patient-reported non-motor domains, including neuropsychiatric, fatigue, sleep, social participation, sensory, autonomic and cognitive outcomes. We used unadjusted analysis to estimate prevalence and adjusted multivariate logistic regression to investigate associated baseline factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 642\/646 (99.3%) eligible surviving patients (median age 73\u00a0years; 43.5% female; median NIHSS\u00a0=\u00a05; mRS\u00a0=\u00a01) treated with IVT, EVT or both. At 6 months, the prevalence of adverse non-motor outcomes across 13 domains ranged from 18% to 56% across all treatment groups. Among patients with a favourable functional outcome (mRS 0\u20132, n\u00a0=\u00a0409), fatigue (51.3%), sleep disturbance (47.6%) and mood problems (39.6%) were most prevalent. In those with an unfavourable outcome (mRS 3\u20135, n\u00a0=\u00a0233), dependency in activities of daily living (51.0%), reduced social participation (44.3%) and bladder dysfunction (41.0%) were common. Stroke recurrence, female sex and baseline NIHSS &amp;gt;\u20095 were significantly associated with multiple adverse non-motor outcomes at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite favourable mRS, a high proportion of patients treated with IVT and\/or EVT report adverse non-motor outcomes. Systematic non-motor assessments alongside mRS are needed to accurately capture post-stroke symptom burden and guide person-centred life after stroke care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag066","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:56:43Z","timestamp":1782151003000},"source":"Crossref","is-referenced-by-count":0,"title":["Patient-reported non-motor outcomes after endovascular thrombectomy and intravenous thrombolysis: an observational study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-4559","authenticated-orcid":false,"given":"Hatice","family":"Ozkan","sequence":"first","affiliation":[{"name":"Stroke Research Centre, Department of Translational Neuroscience and Stroke, UCL Queen Square Institute of Neurology , London ,","place":["United Kingdom"]},{"name":"National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation , Queen Square, London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5322-7327","authenticated-orcid":false,"given":"Gareth","family":"Ambler","sequence":"additional","affiliation":[{"name":"Department of Statistical Science, University College London , Gower Street, London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yezen","family":"Sammaraiee","sequence":"additional","affiliation":[{"name":"Stroke Research Centre, Department of Translational Neuroscience and Stroke, UCL Queen Square Institute of Neurology , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P","family":"Leff","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation , Queen Square, London ,","place":["United 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