{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:10:36Z","timestamp":1783944636306,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centre Hospitalier Regional Universitaire"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intra-arterial thrombolysis (IAT) following successful mechanical thrombectomy (MT) in patients with anterior circulation large-vessel occlusion (LVO) improves cerebral tissue reperfusion and consequently clinical outcome, but has to be validated in non-Asian populations. We hypothesised that IAT with alteplase versus no IAT leads to a better clinical outcome in patients with anterior circulation LVO stroke who have successful angiographic recanalisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Intra-Arterial thrombolysis after SUCCESSful angiographic recanalization in acute large-vessel occlusion stroke of the anterior circulation (IA-SUCCESS) trial is a phase 3 investigator-initiated, multicentre, randomised, open-label, blinded-endpoint (PROBE) clinical trial with a health economic evaluation conducted in France. Patients with acute ischaemic stroke due to anterior circulation LVO within 24\u00a0h of stroke onset and successful angiographic reperfusion (defined as extended Thrombolysis in Cerebral Infarction score 2b\u20133) after intravenous thrombolysis alone, MT alone or both will be randomised in two balanced parallel groups (1:1) to receive either IAT with alteplase (0.225\u00a0mg kg\u20131 and a maximum of 20\u00a0mg) injected in the ipsilateral internal carotid artery or no IAT. A total of 626 patients will be included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study endpoints<\/jats:title>\n                    <jats:p>The primary outcome is the functional outcome on the modified Rankin Scale at 90 (\u00b115) days. Standard secondary clinical outcomes are assessed at 24 (\u00b16) h, 5\u20137\u00a0days, 90 (\u00b115) days and 12 (\u00b11) months. Safety outcomes include mortality at 90 (\u00b115) days and intracranial haemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>The IA-SUCCESS trial will provide high-quality randomised data on the clinical efficacy and safety of intra-arterial alteplase following successful angiographic recanalisation in European patients with ischaemic stroke due to anterior circulation LVO intended for MT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT06768138.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag080","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:21:58Z","timestamp":1783941718000},"source":"Crossref","is-referenced-by-count":0,"title":["Intra-Arterial thrombolysis after SUCCESSful angiographic recanalization in acute large-vessel occlusion stroke of the anterior circulation (IA-SUCCESS): a multicentre, randomised, clinical trial protocol"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-4464","authenticated-orcid":false,"given":"Benjamin","family":"Gory","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Therapeutic Neuroradiology , CHRU-Nancy, Nancy ,","place":["France"]},{"name":"Universit\u00e9 de Lorraine , INSERM, IADI U1254, Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit, Universit\u00e9 , CHRU-Nancy, Nancy ,","place":["France"]},{"name":"INSERM U1116, CHRU-Nancy , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Strasbourg University Hospitals , Strasbourg ,","place":["France"]},{"name":"Institut de Chirurgie Minime Invasive Guid\u00e9e par l\u2019Image , Strasbourg ,","place":["France"]},{"name":"INSERM UMR S1255, Etablissement Fran\u00e7ais du Sang , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Stroke Unit, Strasbourg University Hospitals , Strasbourg ,","place":["France"]},{"name":"UR3072, CRBS , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubaker","family":"Cherifi","sequence":"additional","affiliation":[{"name":"CHRU-Nancy, INSERM, Universit\u00e9 de Lorraine , CIC 1433, Innovation 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