{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:45:18Z","timestamp":1791765918309,"version":"4.3.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471368"],"award-info":[{"award-number":["82471368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Noncommunicable Chronic Disease-National Science and Technology Major Project","award":["2025ZD0552602"],"award-info":[{"award-number":["2025ZD0552602"]}]},{"name":"Clinical and Translational Research Project of Anhui Province","award":["202427b10020090"],"award-info":[{"award-number":["202427b10020090"]}]},{"name":"Clinical and Translational Research Project of Anhui Province","award":["202427b10020053"],"award-info":[{"award-number":["202427b10020053"]}]},{"name":"Excellent Research and Innovation Team Project of Anhui Province","award":["2024AH010014"],"award-info":[{"award-number":["2024AH010014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Evidence regarding the prognostic significance of thrombocytopenia in spontaneous intracerebral haemorrhage (ICH) remains limited and inconsistent. We investigated its associations with haematoma expansion (HE), functional outcomes and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We retrospectively analysed prospectively collected data from consecutive patients with spontaneous ICH in a single-centre registry between August 2022 and March 2025. Thrombocytopenia was defined as an admission platelet count &amp;lt;150\u00a0\u00d7\u00a0109\/L. HE was defined as a haematoma-volume increase &amp;gt;6\u00a0mL or\u00a0&amp;gt;33% on follow-up noncontrast computed tomography. Poor functional outcome was defined as a modified Rankin Scale (mRS) score of 3\u20136 at 3\u00a0months. Associations were assessed using multivariable logistic regression, restricted cubic splines, ordinal regression and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 496 patients, 106 (21.4%) had thrombocytopenia; 368 were included in the HE analysis. After adjustment, thrombocytopenia showed no statistically significant association with HE (adjusted OR 0.97, 95% CI, 0.52\u20131.76; P\u00a0=\u00a0.920), 3-month poor functional outcome (adjusted OR 0.88, 95% CI, 0.46\u20131.66; P\u00a0=\u00a0.693), or 3-month mortality (adjusted OR 1.43, 95% CI, 0.70\u20132.89; P\u00a0=\u00a0.324). Restricted cubic spline analysis showed no statistically significant overall association and the test for nonlinearity was not statistically significant. Findings were similar across platelet-count categories, continuous haematoma-volume changes, ordinal mRS analyses and sensitivity analyses addressing imaging timing, early surgery, acute treatments and prior anticoagulant use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Admission thrombocytopenia showed no statistically significant association with HE, poor functional outcome, or mortality after ICH. Because few patients had platelet counts &amp;lt;100\u00a0\u00d7\u00a0109\/L, these findings mainly apply to mild thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag123","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:01:28Z","timestamp":1791763288000},"source":"Crossref","is-referenced-by-count":0,"title":["Predominantly mild thrombocytopenia, haematoma expansion and clinical outcomes in intracerebral 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