{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:40:41Z","timestamp":1792435241695,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In the hyperacute setting of mechanical thrombectomy (MT) for large-vessel-occlusion stroke, periprocedural platelet inhibition may be required in cases of refractory occlusions or underlying cervical or intracranial arterial disease at risk of reocclusion. Cangrelor is increasingly used in this context, although its use remains largely supported by observational evidence, and the impact of concomitant aspirin remains uncertain. This study investigated the safety and efficacy of the addition of intravenous aspirin to cangrelor during MT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of the Endovascular Treatment in Ischemic Stroke (ETIS) Registry across 34 French comprehensive stroke centres. All consecutive MT patients receiving intraoperative cangrelor between July 2018 and April 2025 were included, irrespective of the indication for intravenous antiplatelet therapy. The primary endpoint was 90-day favourable outcome (modified Rankin Scale [mRS] 0\u20132 or equal to pre-stroke mRS). Secondary outcomes included excellent outcome, early neurological improvement, angiographic recanalisation, day-1 arterial patency and intracranial haemorrhage (ICH). Propensity-score overlap weighting was used to adjust for confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 644 patients were analysed (cangrelor\u00a0+\u00a0aspirin combination: 226; cangrelor alone: 418). Favourable outcomes at 90\u00a0days were similar between groups (57.1% vs 58.8%; adjusted odds ratio [aOR]\u00a0=\u00a00.93; 95% confidence interval, 0.67\u20131.30; P\u00a0=\u00a00.69), as were excellent outcomes and early neurological improvement. Rates of successful and complete reperfusion were similar across groups. No differences were observed for symptomatic ICH (6.2% vs 9.2%; aOR\u00a0=\u00a00.66), any ICH, intra- and extracranial arterial patency on day-1 imaging, or 90-day mortality (22.3% vs 23.9%; aOR\u00a0=\u00a00.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No significant differences in clinical, angiographic or safety outcomes were observed between cangrelor monotherapy and cangrelor combined with intravenous aspirin during MT. These findings provide comparative evidence on two cangrelor-based strategies currently used in clinical practice, although they should not be interpreted as demonstrating equivalence or excluding a potential benefit of adjunctive aspirin. Further prospective studies are needed to clarify the role of aspirin coadministration in this setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/esj\/aakag124","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:18:09Z","timestamp":1792433889000},"source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative cangrelor during mechanical thrombectomy: is the systematic addition of aspirin needed?"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-3192","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Milnerowicz","sequence":"first","affiliation":[{"name":"Neuroradiology Department, Bordeaux University Hospital , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Cagnazzo","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Montpellier University Hospital , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Desilles","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Department, Rothschild Foundation Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00e9va","family":"Kyheng","sequence":"additional","affiliation":[{"name":"Biostatistics Department, Lille University Hospital , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Biostatistics Department, Lille University Hospital , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Consoli","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Neuroradiology Department, Foch Hospital , Suresnes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gory","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Nancy University Hospital , Nancy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Dumas","sequence":"additional","affiliation":[{"name":"Radiology Department, Poitiers University Hospital , Poitiers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jildaz","family":"Caroff","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, NEURI Brain Vascular Center, Bic\u00eatre Hospital, APHP , Kremlin-Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Veunac","sequence":"additional","affiliation":[{"name":"Radiology Department, Bayonne Hospital Center , Bayonne ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Claren\u00e7on","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Piti\u00e9-Salp\u00e9tri\u00e8re University Hospital, APHP , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Gentric","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Brest University Hospital , Brest ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-2627","authenticated-orcid":false,"given":"Christophe","family":"Cognard","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Toulouse University Hospital , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Rouchaud","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Limoges University Hospital , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Soize","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Reims University Hospital , Reims ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Neurology Department, Foch Hospital , Suresnes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-7753","authenticated-orcid":false,"given":"Gaultier","family":"Marnat","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Bordeaux University Hospital , Bordeaux 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