{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:56Z","timestamp":1787008736365,"version":"build-2736575974"},"reference-count":111,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES032452"],"award-info":[{"award-number":["R01ES032452"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21ES027123"],"award-info":[{"award-number":["R21ES027123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21HD098621"],"award-info":[{"award-number":["R21HD098621"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mizzou Forward Faculty Start-up Fund"},{"name":"School of the University of North Carolina at Greensboro Graduate School"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endocrine-disrupting chemicals can induce metabolic alterations, resulting in diseases such as obesity, diabetes, and fatty liver disease, which can be inherited by offspring inhabiting uncontaminated environments. Bisphenol A (BPA), a well-known endocrine disruptor, can induce endocrine disruption, leading to metabolic disorders in subsequent generations without further exposure to BPA via nongenetic transgenerational inheritance. Using medaka as an animal model, we reported that ancestral BPA exposure leads to transgenerational nonalcoholic fatty liver disease (NAFLD) in grandchildren four generations after the initial exposure. It is unclear if transgenerational NAFLD developed because ancestral BPA exposure differs from that developed due to direct and continuous BPA exposure because the transgenerational disease develops in the absence of the stressor. We induced transgenerational NAFLD in medaka with ancestral BPA exposure (10\u2009\u00b5g\/L) at the F0 generation and examined transcriptional and metabolomic alterations in the liver of the F4 generation fish that continued to develop NAFLD. To understand the etiology of NAFLD in unexposed generations, we performed nontargeted liquid chromatography\u2013mass spectrometry-based metabolomic analysis in combination with bulk RNA sequencing and determined biomarkers, co-expressed gene networks, and sex-specific pathways triggered in the liver. An integrated analysis of metabolomic and transcriptional alterations revealed a positive association with the severity of the NAFLD disease phenotype. Females showed increased NAFLD severity and had metabolic disruption involving proline metabolism, tryptophan metabolism, and bile metabolism pathways. The present results provide the transcriptional and metabolomic underpinning of metabolic disruption caused by ancestral BPA exposure, providing avenues for further research to understand the development and progression of transgenerational NAFLD caused by ancestral bisphenol A exposure.<\/jats:p>","DOI":"10.1093\/etojnl\/vgae081","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:36:40Z","timestamp":1736138200000},"page":"958-972","source":"Crossref","is-referenced-by-count":6,"title":["Ancestral bisphenol A exposure led to non-alcoholic fatty liver disease and sex-specific alterations in proline and bile metabolism pathways in the liver"],"prefix":"10.1093","volume":"44","author":[{"given":"Sourav","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of Missouri , Columbia, MO 65211,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Anand","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Missouri , Columbia, MO 65211,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Numan","sequence":"additional","affiliation":[{"name":"Department of Biology, University of North Carolina Greensboro , Greensboro, NC 27412,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-7254","authenticated-orcid":false,"given":"Ramji Kumar","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Missouri , Columbia, MO 65211,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"2025042316173066000_vgae081-B1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1289\/ehp.1001993","article-title":"Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring","volume":"118","author":"Alonso-Magdalena","year":"2010","journal-title":"Environmental Health Perspectives"},{"key":"2025042316173066000_vgae081-B2","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility","volume":"308","author":"Anway","year":"2005","journal-title":"Science"},{"key":"2025042316173066000_vgae081-B3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/elps.201100335","article-title":"Bleach gel: A simple agarose gel for analyzing RNA quality","volume":"33","author":"Aranda","year":"2012","journal-title":"Electrophoresis"},{"key":"2025042316173066000_vgae081-B4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cgh.2020.04.067","article-title":"Women have a lower risk of nonalcoholic fatty liver disease but a higher risk of progression vs men: A systematic review and meta-analysis","volume":"19","author":"Balakrishnan","year":"2021","journal-title":"Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association"},{"key":"2025042316173066000_vgae081-B5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1017\/S2040174418000764","article-title":"Transgenerational effects of maternal bisphenol: A exposure on offspring metabolic health","volume":"10","author":"Bansal","year":"2019","journal-title":"Journal of Developmental Origins of Health and Disease"},{"key":"2025042316173066000_vgae081-B6","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"Journal of Hepatology"},{"key":"2025042316173066000_vgae081-B7","doi-asserted-by":"crossref","first-page":"dvv010","DOI":"10.1093\/eep\/dvv010","article-title":"Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes","volume":"2","author":"Bhandari","year":"2016","journal-title":"Environmental Epigenetics"},{"key":"2025042316173066000_vgae081-B8","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1038\/srep09303","article-title":"Transgenerational effects from early developmental exposures to bisphenol A or 17\u03b1-ethinylestradiol in medaka, Oryzias latipes","volume":"5","author":"Bhandari","year":"2015","journal-title":"Scientific Reports"},{"key":"2025042316173066000_vgae081-B9","doi-asserted-by":"crossref","first-page":"105553","DOI":"10.1016\/j.aquatox.2020.105553","article-title":"Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol a or 17\u03b1-ethinylestradiol in medaka (Oryzias latipes)","volume":"225","author":"Bhandari","year":"2020","journal-title":"Aquatic Toxicology"},{"key":"2025042316173066000_vgae081-B10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-genet-120417-031404","article-title":"Transgenerational epigenetic inheritance","volume":"52","author":"Bo\u0161kovi\u0107","year":"2018","journal-title":"Annual Review of Genetics"},{"key":"2025042316173066000_vgae081-B11","doi-asserted-by":"crossref","first-page":"e28282","DOI":"10.1371\/journal.pone.0028282","article-title":"Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition","volume":"6","author":"Burdge","year":"2011","journal-title":"PLoS One"},{"key":"2025042316173066000_vgae081-B12","doi-asserted-by":"crossref","first-page":"17193","DOI":"10.1038\/s41598-017-17370-6","article-title":"The transcriptomic signature of disease development and progression of nonalcoholic fatty liver disease","volume":"7","author":"Cazanave","year":"2017","journal-title":"Scientific Reports"},{"key":"2025042316173066000_vgae081-B13","doi-asserted-by":"crossref","first-page":"12602","DOI":"10.1021\/acs.est.3c01922","article-title":"The PCOS\u2013NAFLD multidisease phenotype occurred in medaka fish four generations after the removal of bisphenol A exposure","volume":"57","author":"Chakraborty","year":"2023","journal-title":"Environmental Science & Technology"},{"key":"2025042316173066000_vgae081-B14","doi-asserted-by":"crossref","first-page":"159067","DOI":"10.1016\/j.scitotenv.2022.159067","article-title":"Ancestral BPA exposure caused defects in the liver of medaka for four generations","volume":"856","author":"Chakraborty","year":"2023","journal-title":"The Science of the Total Environment"},{"key":"2025042316173066000_vgae081-B15","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: An ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"2025042316173066000_vgae081-B16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/jgh.15709","article-title":"Altered bile acid glycine: Taurine ratio in the progression of chronic liver disease","volume":"37","author":"Chen","year":"2022","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"2025042316173066000_vgae081-B17","doi-asserted-by":"crossref","first-page":"22678","DOI":"10.1074\/jbc.M704213200","article-title":"Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance","volume":"282","author":"Choi","year":"2007","journal-title":"The Journal of Biological Chemistry"},{"key":"2025042316173066000_vgae081-B18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/msb.2008.56","article-title":"Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes","volume":"4","author":"Claus","year":"2008","journal-title":"Molecular Systems Biology"},{"key":"2025042316173066000_vgae081-B19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.reprotox.2007.05.008","article-title":"An ecological assessment of bisphenol-A: Evidence from comparative biology","volume":"24","author":"Crain","year":"2007","journal-title":"Reproductive Toxicology"},{"key":"2025042316173066000_vgae081-B20","doi-asserted-by":"crossref","first-page":"584090","DOI":"10.3389\/fphar.2020.584090","article-title":"Da-chai-hu decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease through remodeling the gut microbiota and modulating the serum metabolism","volume":"11","author":"Cui","year":"2020","journal-title":"Frontiers in Pharmacology"},{"key":"2025042316173066000_vgae081-B21","first-page":"344","article-title":"Prenatal exposure to bisphenol A disrupts mouse fetal liver maturation in a sex-specific manner","volume-title":"Journal of Cellular Biochemistry","author":"DeBenedictis","year":"2016"},{"key":"2025042316173066000_vgae081-B22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: An endocrine society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocrine Reviews"},{"key":"2025042316173066000_vgae081-B23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jhep.2019.10.026","article-title":"Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis","volume":"72","author":"Ding","year":"2020","journal-title":"Journal of Hepatology"},{"key":"2025042316173066000_vgae081-B24","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00726-021-02961-5","article-title":"Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis","volume":"53","author":"Ding","year":"2021","journal-title":"Amino Acids"},{"key":"2025042316173066000_vgae081-B25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2025042316173066000_vgae081-B26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1210\/en.2017-00730","article-title":"Transgenerational effects of bisphenol A on gene expression and DNA methylation of imprinted genes in brain","volume":"159","author":"Drobn\u00e1","year":"2018","journal-title":"Endocrinology"},{"key":"2025042316173066000_vgae081-B27","doi-asserted-by":"crossref","first-page":"W168","DOI":"10.1093\/nar\/gkad393","article-title":"Enrichr-KG: Bridging enrichment analysis across multiple libraries","volume":"51","author":"Evangelista","year":"2023","journal-title":"Nucleic Acids Research"},{"key":"2025042316173066000_vgae081-B28","doi-asserted-by":"crossref","first-page":"118012","DOI":"10.1016\/j.lfs.2020.118012","article-title":"Bisphenol-A exposure worsens hepatic steatosis in ovariectomized mice fed on a high-fat diet: Role of endoplasmic reticulum stress and fibrogenic pathways","volume":"256","author":"Figueiredo","year":"2020","journal-title":"Life Sciences"},{"key":"2025042316173066000_vgae081-B29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrendo.2017.42","article-title":"Endocrine-disrupting chemicals and fatty liver disease","volume":"13","author":"Foulds","year":"2017","journal-title":"Nature Reviews. Endocrinology"},{"key":"2025042316173066000_vgae081-B30","doi-asserted-by":"crossref","first-page":"23664","DOI":"10.1038\/srep23664","article-title":"NADPH oxidase is implicated in the pathogenesis of oxidative phosphorylation dysfunction in mice fed a high-fat diet","volume":"6","author":"Garc\u00eda-Ruiz","year":"2016","journal-title":"Scientific Reports"},{"key":"2025042316173066000_vgae081-B31","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.3390\/ijms23052724","article-title":"Metabolomic and transcript analysis revealed a sex-specific effect of glyphosate in zebrafish liver","volume":"23","author":"Giommi","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"2025042316173066000_vgae081-B32","volume-title":"Transgenerational differences in gut microbiota population and epigenetic responses of host intestinal epithelial cells","author":"Guzman","year":"2021"},{"key":"2025042316173066000_vgae081-B33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1186\/s12885-021-08200-0","article-title":"Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice","volume":"21","author":"Hammad","year":"2021","journal-title":"BMC Cancer"},{"key":"2025042316173066000_vgae081-B34","doi-asserted-by":"crossref","first-page":"e0248351","DOI":"10.1371\/journal.pone.0248351","article-title":"Key hepatic metabolic pathways are altered in germ-free mice during pregnancy","volume":"16","author":"Han","year":"2021","journal-title":"PLoS One"},{"key":"2025042316173066000_vgae081-B35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1172\/JCI107200","article-title":"Metabolism of steroid and amino acid moieties of conjugated bile acids in man. 3. Cholyltaurine (taurocholic acid)","volume":"52","author":"Hepner","year":"1973","journal-title":"The Journal of Clinical Investigation"},{"key":"2025042316173066000_vgae081-B36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut\u2013liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nature Reviews. Microbiology"},{"key":"2025042316173066000_vgae081-B37","author":"Irshad","year":"2021"},{"key":"2025042316173066000_vgae081-B38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pbiomolbio.2012.08.014","article-title":"Epigenetic inheritance and plasticity: The responsive germline","volume":"111","author":"Jablonka","year":"2013","journal-title":"Progress in Biophysics and Molecular Biology"},{"key":"2025042316173066000_vgae081-B39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2014.04.013","article-title":"Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring","volume":"228","author":"Jiang","year":"2014","journal-title":"Toxicology Letters"},{"key":"2025042316173066000_vgae081-B40","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.aquatox.2010.10.005","article-title":"Environmental cues influence EDC-mediated endocrine disruption effects in different developmental stages of Japanese medaka (Oryzias latipes)","volume":"101","author":"Jin","year":"2011","journal-title":"Aquatic Toxicology"},{"key":"2025042316173066000_vgae081-B41","doi-asserted-by":"crossref","first-page":"106000","DOI":"10.1016\/j.mimet.2020.106000","article-title":"Targeted and untargeted analysis of secondary metabolites to monitor growth and quorum sensing inhibition for methicillin-resistant Staphylococcus aureus (MRSA)","volume":"176","author":"Jones","year":"2020","journal-title":"Journal of Microbiological Methods"},{"key":"2025042316173066000_vgae081-B42","doi-asserted-by":"crossref","first-page":"31331","DOI":"10.1038\/srep31331","article-title":"Bisphenol A exposure may induce hepatic lipid accumulation via reprogramming the DNA methylation patterns of genes involved in lipid metabolism","volume":"6","author":"Ke","year":"2016","journal-title":"Scientific Reports"},{"key":"2025042316173066000_vgae081-B43","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/liv.14110","article-title":"Elevated urinary bisphenol A levels are associated with non-alcoholic fatty liver disease among adults in the United States","volume":"39","author":"Kim","year":"2019","journal-title":"Liver International: Official Journal of the International Association for the Study of the Liver"},{"key":"2025042316173066000_vgae081-B44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00726-014-1894-9","article-title":"Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease","volume":"47","author":"Lake","year":"2015","journal-title":"Amino Acids"},{"key":"2025042316173066000_vgae081-B45","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1001\/jama.300.11.1303","article-title":"Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults","volume":"300","author":"Lang","year":"2008","journal-title":"JAMA"},{"key":"2025042316173066000_vgae081-B46","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.scitotenv.2017.10.042","article-title":"Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother\u2013neonate pairs","volume":"626","author":"Lee","year":"2018","journal-title":"The Science of the Total Environment"},{"key":"2025042316173066000_vgae081-B47","doi-asserted-by":"crossref","first-page":"101612","DOI":"10.1016\/j.molmet.2022.101612","article-title":"Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia","volume":"66","author":"Lemecha","year":"2022","journal-title":"Molecular Metabolism"},{"key":"2025042316173066000_vgae081-B48","doi-asserted-by":"crossref","first-page":"110786","DOI":"10.1016\/j.fct.2019.110786","article-title":"Bisphenol A exposure induces cholesterol synthesis and hepatic steatosis in C57BL\/6 mice by down-regulating the DNA methylation levels of SREBP-2","volume":"133","author":"Li","year":"2019","journal-title":"Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association"},{"key":"2025042316173066000_vgae081-B49","first-page":"D504","article-title":"SIGNOR 2.0, the SIGnaling network open resource 2.0: 2019 update","volume":"48","author":"Licata","year":"2020","journal-title":"Nucleic Acids Research"},{"key":"2025042316173066000_vgae081-B50","doi-asserted-by":"crossref","first-page":"106197","DOI":"10.1016\/j.aquatox.2022.106197","article-title":"Toxic effects of waterborne benzylparaben on the growth, antioxidant capacity and lipid metabolism of Nile tilapia (Oreochromis niloticus)","volume":"248","author":"Lin","year":"2022","journal-title":"Aquatic Toxicology"},{"key":"2025042316173066000_vgae081-B51","doi-asserted-by":"crossref","first-page":"107769","DOI":"10.1016\/j.envint.2023.107769","article-title":"Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice","volume":"172","author":"Liu","year":"2023","journal-title":"Environment International"},{"key":"2025042316173066000_vgae081-B52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11745-016-4222-1","article-title":"Eicosapentaenoic acid-enriched phosphatidylcholine attenuated hepatic steatosis through regulation of cholesterol metabolism in rats with nonalcoholic fatty liver disease","volume":"52","author":"Liu","year":"2017","journal-title":"Lipids"},{"key":"2025042316173066000_vgae081-B53","doi-asserted-by":"crossref","first-page":"18029","DOI":"10.1038\/s41598-019-54368-8","article-title":"Genetic and epigenetic alterations induced by bisphenol A exposure during different periods of spermatogenesis: From spermatozoa to the progeny","volume":"9","author":"Lomb\u00f3","year":"2019","journal-title":"Scientific Reports"},{"key":"2025042316173066000_vgae081-B54","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.envpol.2015.08.016","article-title":"Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure","volume":"206","author":"Lombo","year":"2015","journal-title":"Environmental Pollution"},{"key":"2025042316173066000_vgae081-B55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10565-020-09535-3","article-title":"Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPAR\u03b3","volume":"37","author":"Long","year":"2021","journal-title":"Cell Biology and Toxicology"},{"key":"2025042316173066000_vgae081-B56","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biology"},{"key":"2025042316173066000_vgae081-B57","doi-asserted-by":"crossref","first-page":"1169811","DOI":"10.3389\/fmicb.2023.1169811","article-title":"Alterations in the intestinal microbiome and metabolic profile of patients with cirrhosis supplemented with lactulose, Clostridium butyricum, and Bifidobacterium longum infantis: A randomized placebo-controlled trial","volume":"14","author":"Lu","year":"2023","journal-title":"Frontiers in Microbiology"},{"key":"2025042316173066000_vgae081-B58","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tiv.2019.05.013","article-title":"Bisphenol A promotes macrophage proinflammatory subtype polarization via upregulation of IRF5 expression in vitro","volume":"60","author":"Lu","year":"2019","journal-title":"Toxicology In Vitro"},{"key":"2025042316173066000_vgae081-B59","doi-asserted-by":"crossref","first-page":"3654660","DOI":"10.1155\/2021\/3654660","article-title":"Target deconvolution of fenofibrate in nonalcoholic fatty liver disease using bioinformatics analysis","volume":"2021","author":"Mahmoudi","year":"2021","journal-title":"BioMed Research International"},{"key":"2025042316173066000_vgae081-B60","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1677\/joe.0.1470285","article-title":"Immunolocalisation of androgen receptor to interstitial cells in fetal rat testes and to mesenchymal and epithelial cells of associated ducts","volume":"147","author":"Majdic","year":"1995","journal-title":"The Journal of Endocrinology"},{"key":"2025042316173066000_vgae081-B61","doi-asserted-by":"crossref","first-page":"e55387","DOI":"10.1371\/journal.pone.0055387","article-title":"Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations","volume":"8","author":"Manikkam","year":"2013","journal-title":"PLoS One"},{"key":"2025042316173066000_vgae081-B62","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1210\/en.2015-1384","article-title":"Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop","volume":"157","author":"Martella","year":"2016","journal-title":"Endocrinology"},{"key":"2025042316173066000_vgae081-B63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/msb4100153","article-title":"A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model","volume":"3","author":"Martin","year":"2007","journal-title":"Molecular Systems Biology"},{"key":"2025042316173066000_vgae081-B64","doi-asserted-by":"crossref","first-page":"127080","DOI":"10.1016\/j.chemosphere.2020.127080","article-title":"Acute and long-term metabolic consequences of early developmental bisphenol A exposure in zebrafish (Danio rerio)","volume":"256","author":"Mart\u00ednez","year":"2020","journal-title":"Chemosphere"},{"key":"2025042316173066000_vgae081-B65","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1242\/dmm.002311","article-title":"Medaka as a model for human nonalcoholic steatohepatitis","volume":"3","author":"Matsumoto","year":"2010","journal-title":"Disease Models & Mechanisms"},{"key":"2025042316173066000_vgae081-B66","doi-asserted-by":"crossref","first-page":"112050","DOI":"10.1016\/j.ecoenv.2021.112050","article-title":"Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus","volume":"213","author":"Mi","year":"2021","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2025042316173066000_vgae081-B67","doi-asserted-by":"crossref","first-page":"AB119","DOI":"10.1016\/j.jaci.2022.12.376","article-title":"Bisphenol A (BPA) has transgenerational effects on the development of experimental asthma through BRD4\/ZDHHC-1\/STING axis","volume":"151","author":"Midoro-Horiuti","year":"2023","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"2025042316173066000_vgae081-B68","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/15376516.2015.1056395","article-title":"Effect of bisphenol A on blood glucose, lipid profile and oxidative stress indices in adult male mice","volume":"25","author":"Moghaddam","year":"2015","journal-title":"Toxicology Mechanisms and Methods"},{"key":"2025042316173066000_vgae081-B69","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/hep.32324","article-title":"Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD","volume":"76","author":"Moore","year":"2022","journal-title":"Hepatology"},{"key":"2025042316173066000_vgae081-B70","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/2211-5463.12240","article-title":"Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease","volume":"7","author":"Mukai","year":"2017","journal-title":"FEBS Open Bio"},{"key":"2025042316173066000_vgae081-B71","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.clinbiochem.2010.04.003","article-title":"Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes","volume":"43","author":"Narasimhan","year":"2010","journal-title":"Clinical Biochemistry"},{"key":"2025042316173066000_vgae081-B72","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cmet.2012.01.024","article-title":"Interplay between lipids and branched-chain amino acids in development of insulin resistance","volume":"15","author":"Newgard","year":"2012","journal-title":"Cell Metabolism"},{"key":"2025042316173066000_vgae081-B73","author":"Ngo","year":"2017"},{"key":"2025042316173066000_vgae081-B74","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envpol.2017.07.095","article-title":"Metabolic disruption of zebrafish (Danio rerio) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach","volume":"231","author":"Ortiz-Villanueva","year":"2017","journal-title":"Environmental Pollution"},{"key":"2025042316173066000_vgae081-B75","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41596-022-00710-w","article-title":"Using MetaboAnalyst 5.0 for LC\u2013HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data","volume":"17","author":"Pang","year":"2022","journal-title":"Nature Protocols"},{"key":"2025042316173066000_vgae081-B76","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bbabio.2007.07.011","article-title":"Mitochondrial dysfunction in rat with nonalcoholic fatty liver: Involvement of complex I, reactive oxygen species and cardiolipin","volume":"1767","author":"Petrosillo","year":"2007","journal-title":"Biochimica et Biophysica Acta"},{"key":"2025042316173066000_vgae081-B77","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/1471-2105-11-395","article-title":"MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data","volume":"11","author":"Pluskal","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2025042316173066000_vgae081-B78","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1210\/jc.2015-2649","article-title":"Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men","volume":"100","author":"Pramfalk","year":"2015","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2025042316173066000_vgae081-B79","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.reprotox.2019.03.002","article-title":"Developmental programming: Changes in mediators of insulin sensitivity in prenatal bisphenol A-treated female sheep","volume":"85","author":"Puttabyatappa","year":"2019","journal-title":"Reproductive Toxicology"},{"key":"2025042316173066000_vgae081-B80","doi-asserted-by":"crossref","first-page":"C931","DOI":"10.1152\/ajpcell.00474.2005","article-title":"Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K\/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27","volume":"291","author":"Rafiee","year":"2006","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"2025042316173066000_vgae081-B81","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.reprotox.2007.06.004","article-title":"In vivo effects of bisphenol A in laboratory rodent studies","volume":"24","author":"Richter","year":"2007","journal-title":"Reproductive Toxicology"},{"key":"2025042316173066000_vgae081-B82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1600-079X.2003.00092.x","article-title":"Regulation of antioxidant enzymes: A significant role for melatonin","volume":"36","author":"Rodriguez","year":"2004","journal-title":"Journal of Pineal Research"},{"key":"2025042316173066000_vgae081-B83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Comprehensive Physiology"},{"key":"2025042316173066000_vgae081-B84","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3390\/nu12082178","article-title":"The importance of the fatty acid transporter L-carnitine in non-alcoholic fatty liver disease (NAFLD)","volume":"12","author":"Savic","year":"2020","journal-title":"Nutrients"},{"key":"2025042316173066000_vgae081-B85","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12986-015-0012-7","article-title":"E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish","volume":"12","author":"Shimada","year":"2015","journal-title":"Nutrition & Metabolism"},{"key":"2025042316173066000_vgae081-B86","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/bdrc.20199","article-title":"Role of epigenetics in developmental biology and transgenerational inheritance","volume":"93","author":"Skinner","year":"2011","journal-title":"Birth Defects Research. Part C, Embryo Today: Reviews"},{"key":"2025042316173066000_vgae081-B87","doi-asserted-by":"crossref","first-page":"6729","DOI":"10.1021\/ac051080y","article-title":"Fusion of mass spectrometry-based metabolomics data","volume":"77","author":"Smilde","year":"2005","journal-title":"Analytical Chemistry"},{"key":"2025042316173066000_vgae081-B88","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/10408444.2012.692114","article-title":"Endocrine disrupting chemicals and sexual behaviors in fish\u2014A critical review on effects and possible consequences","volume":"42","author":"S\u00f6ffker","year":"2012","journal-title":"Critical Reviews in Toxicology"},{"key":"2025042316173066000_vgae081-B89","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gde.2014.03.008","article-title":"Epigenetic inheritance of metabolic state","volume":"27","author":"Somer","year":"2014","journal-title":"Current Opinion in Genetics & Development"},{"key":"2025042316173066000_vgae081-B90","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.taap.2015.02.021","article-title":"Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis","volume":"284","author":"Strakovsky","year":"2015","journal-title":"Toxicology and Applied Pharmacology"},{"key":"2025042316173066000_vgae081-B91","doi-asserted-by":"crossref","first-page":"126318","DOI":"10.1016\/j.chemosphere.2020.126318","article-title":"Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq","volume":"251","author":"Sun","year":"2020","journal-title":"Chemosphere"},{"key":"2025042316173066000_vgae081-B92","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1210\/en.2014-2027","article-title":"Bisphenol A exposure disrupts metabolic health across multiple generations in the mouse","volume":"156","author":"Susiarjo","year":"2015","journal-title":"Endocrinology"},{"key":"2025042316173066000_vgae081-B93","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/biolre\/ioaa169","article-title":"Bisphenol A and 17\u03b1-ethinylestradiol-induced transgenerational gene expression differences in the brain\u2013pituitary\u2013testis axis of medaka, Oryzias latipes","volume":"103","author":"Thayil","year":"2020","journal-title":"Biology of Reproduction"},{"key":"2025042316173066000_vgae081-B94","doi-asserted-by":"crossref","first-page":"736061","DOI":"10.1016\/j.aquaculture.2020.736061","article-title":"An untargeted LC-MS metabolomics approach to the metabolic profiles of bottom cultured scallops (Mizuhopecten yessoensis) subjected to mechanical shock in early post-harvest handling","volume":"533","author":"Tian","year":"2021","journal-title":"Aquaculture"},{"key":"2025042316173066000_vgae081-B95","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-079X.2005.00248.x","article-title":"A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes","volume":"39","author":"Tom\u00e1s-Zapico","year":"2005","journal-title":"Journal of Pineal Research"},{"key":"2025042316173066000_vgae081-B96","doi-asserted-by":"crossref","first-page":"e0220659","DOI":"10.1371\/journal.pone.0220659","article-title":"Plasma ApoE elevations are associated with NAFLD: The PREVEND Study","volume":"14","author":"van den Berg","year":"2019","journal-title":"PloS One"},{"key":"2025042316173066000_vgae081-B97","volume-title":"Pathogenesis of liver fibrosis and regeneration in the Japanese Medaka (Oryzias latipes)","author":"Van Wettere","year":"2012"},{"key":"2025042316173066000_vgae081-B98","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1289\/ehp.0901716","article-title":"Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A","volume":"118","author":"Vandenberg","year":"2010","journal-title":"Environmental Health Perspectives"},{"key":"2025042316173066000_vgae081-B99","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.dld.2015.01.048","article-title":"A novel role for the kynurenine pathway in experimental steatohepatitis","volume":"47","author":"Vivoli","year":"2015","journal-title":"Digestive and Liver Disease"},{"key":"2025042316173066000_vgae081-B100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chemosphere.2019.01.033","article-title":"Toxic effects of bisphenol A on goldfish gonad development and the possible pathway of BPA disturbance in female and male fish reproduction","volume":"221","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"key":"2025042316173066000_vgae081-B101","doi-asserted-by":"crossref","first-page":"dvaa008","DOI":"10.1093\/eep\/dvaa008","article-title":"DNA methylation reprogramming in medaka fish, a promising animal model for environmental epigenetics research","volume":"6","author":"Wang","year":"2020","journal-title":"Environmental Epigenetics"},{"key":"2025042316173066000_vgae081-B102","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/15592294.2019.1695341","article-title":"The dynamics of DNA methylation during epigenetic reprogramming of primordial germ cells in medaka (Oryzias latipes)","volume":"15","author":"Wang","year":"2020","journal-title":"Epigenetics"},{"key":"2025042316173066000_vgae081-B103","doi-asserted-by":"crossref","first-page":"10459","DOI":"10.1007\/s13277-016-4923-3","article-title":"FOXR2 contributes to cell proliferation and malignancy in human hepatocellular carcinoma","volume":"37","author":"Wang","year":"2016","journal-title":"Tumour Biology"},{"key":"2025042316173066000_vgae081-B104","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.aquatox.2019.04.005","article-title":"Bisphenol A and 17\u03b1-ethinylestradiol-induced transgenerational differences in expression of osmoregulatory genes in the gill of medaka (Oryzias latipes)","volume":"211","author":"Wang","year":"2019","journal-title":"Aquatic Toxicology"},{"key":"2025042316173066000_vgae081-B105","doi-asserted-by":"crossref","first-page":"156815","DOI":"10.1016\/j.scitotenv.2022.156815","article-title":"Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice","volume":"842","author":"Wei","year":"2022","journal-title":"The Science of the Total Environment"},{"key":"2025042316173066000_vgae081-B106","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.yhbeh.2013.09.007","article-title":"Transgenerational effects of prenatal bisphenol A on social recognition","volume":"64","author":"Wolstenholme","year":"2013","journal-title":"Hormones and Behavior"},{"key":"2025042316173066000_vgae081-B107","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s10620-020-06208-3","article-title":"Deoxycholic acid-induced gut dysbiosis disrupts bile acid enterohepatic circulation and promotes intestinal inflammation","volume":"66","author":"Xu","year":"2021","journal-title":"Digestive Diseases and Sciences"},{"key":"2025042316173066000_vgae081-B108","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0045-6535(00)00079-5","article-title":"Bisphenol A in hazardous waste landfill leachates","volume":"42","author":"Yamamoto","year":"2001","journal-title":"Chemosphere"},{"key":"2025042316173066000_vgae081-B109","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1074\/mcp.RA118.001035","article-title":"Integrated succinylome and metabolome profiling reveals crucial role of s-ribosylhomocysteine lyase in quorum sensing and metabolism of aeromonas hydrophila*[S]","volume":"18","author":"Yao","year":"2019","journal-title":"Molecular & Cellular Proteomics: MCP"},{"key":"2025042316173066000_vgae081-B110","volume-title":"Nonalcoholic fatty liver disease\u2014An update","author":"Zhang","year":"2018"},{"key":"2025042316173066000_vgae081-B111","doi-asserted-by":"crossref","first-page":"e0178535","DOI":"10.1371\/journal.pone.0178535","article-title":"Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men","volume":"12","author":"Zheng","year":"2017","journal-title":"PLoS One"}],"container-title":["Environmental Toxicology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/etc\/advance-article-pdf\/doi\/10.1093\/etojnl\/vgae081\/61340118\/vgae081.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/44\/4\/958\/61340118\/vgae081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/44\/4\/958\/61340118\/vgae081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:18:16Z","timestamp":1745425096000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/etc\/article\/44\/4\/958\/7942994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":111,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,1,6]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/etojnl\/vgae081","relation":{},"ISSN":["0730-7268","1552-8618"],"issn-type":[{"value":"0730-7268","type":"print"},{"value":"1552-8618","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,1,6]]}}}