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Although no differences (p\u2009&amp;gt;\u20090.05) were noted in either the egg incubation time or the postlarvae survival, the number of hatched postlarvae (actual fecundity) decreased to some extent, together with a low percentage of abnormal larvae. At the end of the assay, the ovarian size of rematurating shrimps exposed to 1\u2009mg\/L of diclofenac was significantly (p\u2009&amp;lt;\u20090.05) higher than that of controls, showing an acceleration of ovarian growth by the effect of this drug. Taken together, however, these results showed no evident increase of reproductive output. Concerning oxidative stress, both the reduced glutathione level and total antioxidant capacity were enhanced without altering glutathione-S-transferase activity and lipid peroxidation. Concomitantly, no damage to the hepatopancreas structure was observed in females. We conclude that diclofenac caused an imbalance in gonadal growth, likely by affecting the endocrine control exerted by prostaglandins, whereas oxidative stress could be efficiently controlled by the induction of antioxidant defenses.<\/jats:p>","DOI":"10.1093\/etojnl\/vgaf070","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T18:57:17Z","timestamp":1743361037000},"page":"1647-1654","source":"Crossref","is-referenced-by-count":2,"title":["Diclofenac activates antioxidant defenses and affects ovarian growth in the freshwater shrimp <i>Macrobrachium borellii<\/i>"],"prefix":"10.1093","volume":"44","author":[{"given":"Marina","family":"Zanitti","sequence":"first","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda de Crust\u00e1ceos, Departamento de Biodiversidad y Biolog\u00eda Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Buenos Aires,","place":["Argentina"]},{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Calabr\u00f3 L\u00f3pez","sequence":"additional","affiliation":[{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael E","family":"Lozano","sequence":"additional","affiliation":[{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) , Buenos Aires,","place":["Argentina"]},{"name":"Laboratorio de Ecotoxicolog\u00eda Acu\u00e1tica, Departamento de Biodiversidad y Biolog\u00eda Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Medesani","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda de Crust\u00e1ceos, Departamento de Biodiversidad y Biolog\u00eda Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Buenos Aires,","place":["Argentina"]},{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-9309","authenticated-orcid":false,"given":"Ariadna G","family":"Battista","sequence":"additional","affiliation":[{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S","family":"L\u00f3pez Greco","sequence":"additional","affiliation":[{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) , Buenos Aires,","place":["Argentina"]},{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Crecimiento y Nutrici\u00f3n de Crust\u00e1ceos Dec\u00e1podos. 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