{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T01:20:53Z","timestamp":1772673653999,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Wuhan Center for Disease Control and Prevention","award":["20222605"],"award-info":[{"award-number":["20222605"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Halogenated disinfection by-products are contaminants in drinking water that pose a significant public health concern. The intestine is particularly susceptible to the effects of disinfection by-products through oral ingestion; however, the intestinal toxicity of these compounds remains largely unexplored. This study aimed to assess the impact of 10 haloacetic acids, a major class of drinking water disinfection by-products, on intestinal barrier function using Caenorhabditis elegans as a model animal. Additionally, changes in the expression of five genes related to intestinal barrier function (mucin-like gene [mul-1], zonula occludens ortholog gene [zoo-1], gut esterase 1 gene [ges-1], cytochrome P450 gene [cyp13a7], and saposin-like protein family gene [spp-5]) were examined using quantitative real-time polymerase chain reaction. Among the investigated haloacetic acids (chloroacetic acid, bromoacetic acid, iodoacetic acid, dibromoacetic acid, dichloroacetic acid, bromochloroacetic acid, bromodichloroacetic acid, dibromochloroacetic acid, trichloroacetic acid, and tribromoacetic acid), exposure to five haloacetic acids (dichloroacetic acid, bromodichloroacetic acid, dibromochloroacetic acid, trichloroacetic acid, and tribromoacetic acid) could lead to significant disruption of the intestinal barrier, as evidenced by the induced increase in intestinal permeability in C. elegans. The order of enterotoxicity, based on assessments of intestinal permeability, is trichloroacetic acid &amp;gt; bromodichloroacetic acid\u00a0\u2248\u00a0dibromochloroacetic acid\u00a0\u2248\u00a0tribromoacetic acid &amp;gt; dichloroacetic acid. These five compounds suppressed the expression of both the tight junction (zoo-1) and xenobiotic-metabolizing (ges-1) genes, suggesting that these two genes may be of vital importance in haloacetic acid-induced intestinal toxicity. This work contributes to improving the available knowledge on the toxicity of haloacetic acids and provides a basis for understanding their mechanism of intestinal toxicity.<\/jats:p>","DOI":"10.1093\/etojnl\/vgaf129","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T13:52:14Z","timestamp":1747403534000},"page":"2233-2243","source":"Crossref","is-referenced-by-count":3,"title":["Effect of haloacetic acid water disinfection by-products on intestinal barrier function in nematode <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"44","author":[{"given":"Jun-Ling","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan,","place":["China"]},{"name":"State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji 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