{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T21:44:37Z","timestamp":1776030277744,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["43006082"],"award-info":[{"award-number":["43006082"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pharmaceuticals and metals in municipal wastewater pose significant risks to human and environmental health, necessitating further investigation due to their increasing use and limited data. This study assessed the impacts of commonly prescribed pharmaceuticals and metals in Tehran\u2019s (Iran) municipal wastewater using the USEtox model, which quantifies chemical toxicity by integrating fate, exposure, and effect factors. In Tehran, 61% of untreated wastewater is released into watercourses, while 39% is treated by an activated sludge system and partially reused for agriculture. Target pharmaceuticals and metals were detected in both untreated and treated wastewater, with detection frequencies ranging from 33% to 100% for pharmaceuticals and 50% to 100% for metals. Acetaminophen (7.7\u2009\u00b5g\/L) and zinc (88.4\u2009\u00b5g\/L) had the highest concentrations in untreated wastewater, while citalopram (0.4\u2009\u00b5g\/L) and zinc (55.1\u2009\u00b5g\/L) dominated in treated wastewater. The lowest concentrations were for alprazolam, vanadium, and beryllium, ranging from 2 to 100\u2009ng\/L. The estimated health burden of pharmaceuticals and metals, based on ingestion risk and measured in disability-adjusted life year (DALY) per 100,000 people, was 0.03 for pharmaceuticals and 33 for metals, indicating years of healthy life lost due to illness or death. The environmental impact, measured by the potentially disappeared fraction (PDF) of species, reached 7.4E\u2009+\u200906 (PDF.m\u00b3\/year) for pharmaceuticals and 1.4E\u2009+\u200909 (PDF.m\u00b3\/year) for metals, indicating a significant loss of biodiversity. Sertraline and cadmium posed the greatest risks to human health, while thioridazine and cadmium were found to be most detrimental to ecosystems. These findings underscore the urgent need for improved wastewater management and further research into high-risk micropollutants.<\/jats:p>","DOI":"10.1093\/etojnl\/vgaf138","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:54:54Z","timestamp":1748591694000},"page":"821-833","source":"Crossref","is-referenced-by-count":2,"title":["Human health and ecological impacts of pharmaceuticals and metals released by municipal wastewater in Tehran: a life cycle impact assessment"],"prefix":"10.1093","volume":"45","author":[{"given":"Somayeh","family":"Golbaz","sequence":"first","affiliation":[{"name":"Workplace Health Promotion Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences , Tehran,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirzaman","family":"Zamanzadeh","sequence":"additional","affiliation":[{"name":"inCTRL Solutions Inc , Dundas,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnoosh","family":"Abtahi","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences , Tehran,","place":["Iran"]},{"name":"Environmental and Occupational Hazards Control Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences , Tehran,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Dobaradaran","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences , Bushehr,","place":["Iran"]},{"name":"Systems Environmental Health and Energy Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr,","place":["Iran"]},{"name":"Centre for Water and Environmental Research, University of Duisburg-Essen , Essen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Paeezi","sequence":"additional","affiliation":[{"name":"Department of Health, Safety and Environment (HSE), School of Public Health and Safety, Shahid Beheshti University of Medical Sciences , Tehran,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Hajighasemkhan","sequence":"additional","affiliation":[{"name":"Department of Occupational Health Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Science , Tehran,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Workplace Health Promotion Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences , Tehran,","place":["Iran"]},{"name":"Department of Health, Safety and Environment (HSE), School of Public Health and Safety, Shahid Beheshti University of Medical Sciences , Tehran,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"2026041217150552700_vgaf138-B1","doi-asserted-by":"crossref","first-page":"116524","DOI":"10.1016\/j.watres.2020.116524","article-title":"Impact assessment of a large panel of organic and inorganic micropollutants released by wastewater treatment plants at the scale of France","volume":"188","author":"Aemig","year":"2021","journal-title":"Water Research"},{"key":"2026041217150552700_vgaf138-B2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.34172\/jaehr.2023.08","article-title":"Municipal wastewater treatment in Iran: Current situation, barriers and future 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Potential interactions and the influence of the environment","volume":"540","author":"Andreu","year":"2016","journal-title":"Science of the Total Environment"},{"key":"2026041217150552700_vgaf138-B6","doi-asserted-by":"crossref","first-page":"122432","DOI":"10.1016\/j.jclepro.2020.122432","article-title":"The innovation of the characterisation factor estimation for LCA in the USEtox model","volume":"270","author":"Belyanovskaya","year":"2020","journal-title":"Journal of Cleaner Production"},{"key":"2026041217150552700_vgaf138-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2011.09.002","article-title":"Update of carcinogenicity studies in animals and humans of 535 marketed pharmaceuticals","volume":"750","author":"Brambilla","year":"2012","journal-title":"Mutation Research"},{"key":"2026041217150552700_vgaf138-B8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/10937404.2018.1465873","article-title":"Application of prioritization approaches to 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