{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:51Z","timestamp":1787961651628,"version":"build-2784847793"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["U2032132"],"award-info":[{"award-number":["U2032132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cross-disciplinary Research Fund of Shanghai Ninth People\u2019s Hospital"},{"name":"Shanghai JiaoTong University School of Medicine","award":["JYJC202218"],"award-info":[{"award-number":["JYJC202218"]}]},{"name":"Analytical Instrumentation Center"},{"DOI":"10.13039\/501100014900","name":"School of Physical Science and Technology, ShanghaiTech University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The utilization of carbon dioxide (CO2) as a raw material for synthesizing CO2-based polymers presents a promising large-scale strategy for its consumption and transformation. The recent successful syntheses of degradable and monomer-recyclable polyesters from CO2 and butadiene-derived monomers represent a series of significant advancements. These monomers include 1,2-ethylidene-6-vinyl-tetrahydro-2H-pyran-2-one (\u03b4-L), 3,6-diethyl-tetrahydro-2H-pyran-2-one (HL), and 3-ethyl-6-vinyltetrahydro2H-pyran-2-one (\u03b4LH2). These developments are promising in meeting the urgent needs to achieve a circular economy in the current plastic industry. Herein, we reported the first study on the cytotoxicity of \u03b4-L, HL, and \u03b4LH2. The effect concentration causing 50% inhibition of cell viability after 72\u2009hr was determined to be &amp;lt;\u20090.25\u2009mM for \u03b4-L, 2.01\u2009mM for HL, and 1.98\u2009mM for \u03b4LH2. Mechanistic studies showed that the surprisingly high cytotoxicity of \u03b4-L cannot be rationalized solely by the reactivity of its conjugated olefin as a Michael acceptor towards thiols. Based on these findings, \u03b4LH2 and HL are considered relatively suitable for potential large-scale applications, whereas \u03b4-L requires additional protective measures.<\/jats:p>","DOI":"10.1093\/etojnl\/vgaf158","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T13:04:33Z","timestamp":1750943073000},"page":"2703-2706","source":"Crossref","is-referenced-by-count":2,"title":["Cytotoxicity of three carbon dioxide\/butadiene-derived monomers"],"prefix":"10.1093","volume":"44","author":[{"given":"Yuxuan","family":"Niu","sequence":"first","affiliation":[{"name":"School of Technology and Physical Science, ShanghaiTech University , Shanghai, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Technology and Physical Science, ShanghaiTech University , Shanghai, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-0557","authenticated-orcid":false,"given":"Bo-Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Technology and Physical Science, ShanghaiTech University , Shanghai, P. 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Molecular dynamic investigation on passive membrane penetration by the products of the CO2 and 1,3-butadiene reaction","volume":"361","author":"R\u00f3zsa","year":"2022","journal-title":"Journal of Molecular Liquids"},{"key":"2025093001514588400_vgaf158-B14","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1021\/acs.chemrev.3c00847","article-title":"Sustainable copolymer synthesis from carbon dioxide and butadiene","volume":"124","author":"Tang","year":"2024","journal-title":"Chemical Reviews"},{"key":"2025093001514588400_vgaf158-B15","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202400163","article-title":"Monomer-recyclable polyester from CO2 and 1,3-butadiene","volume":"45","author":"Xu","year":"2024","journal-title":"Macromolecular Rapid Communications"},{"key":"2025093001514588400_vgaf158-B16","doi-asserted-by":"publisher","first-page":"8698","DOI":"10.1038\/s41467-024-52090-2","article-title":"Bifunctional and recyclable polyesters by chemoselective ring-opening polymerization of a \u03b4-lactone derived from CO2 and butadiene","volume":"15","author":"Zhang","year":"2024","journal-title":"Nature Communications"}],"container-title":["Environmental Toxicology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/etc\/advance-article-pdf\/doi\/10.1093\/etojnl\/vgaf158\/63501442\/vgaf158.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/44\/10\/2703\/63501442\/vgaf158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/etc\/article-pdf\/44\/10\/2703\/63501442\/vgaf158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:52:10Z","timestamp":1759211530000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/etc\/article\/44\/10\/2703\/8164028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":16,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,6,16]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/etojnl\/vgaf158","relation":{},"ISSN":["0730-7268","1552-8618"],"issn-type":[{"value":"0730-7268","type":"print"},{"value":"1552-8618","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,6,16]]}}}