{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:44:49Z","timestamp":1784976289758,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES\u2014001"],"award-info":[{"award-number":["CAPES\u2014001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ototoxicity is the adverse reaction in the auditory system caused by exposure to xenobiotics. Animal models have been used to improve the understanding of ototoxicity research. Zebrafish (Danio rerio) is a model animal that is being increasingly used in ototoxicity research. Here, we identified and map the evidence on the use of zebrafish as an animal model to study ototoxicity. We conducted an exploratory systematic search in the three databases (Cochrane, LILACS, and PubMed) with a two-step screening process based on inclusion\/exclusion criteria. Outcome measures of included nondrug xenobiotics studies (n\u2009=\u200915) and drugs (n\u2009=\u2009118) were grouped into hair cell death rate, exposure time, and developmental stages. Our review indicates zebrafish to be an important model to screen the ototoxicity potential of xenobiotics but also demonstrates that novel studies are necessary to define the most appropriate evaluation outcomes and specific protocol.<\/jats:p>","DOI":"10.1093\/etojnl\/vgaf161","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T21:16:03Z","timestamp":1751058963000},"page":"2744-2753","source":"Crossref","is-referenced-by-count":2,"title":["Studying ototoxicity in zebrafish"],"prefix":"10.1093","volume":"44","author":[{"given":"Eduarda","family":"Oliveira Cunha","sequence":"first","affiliation":[{"name":"Graduate Program in Health Sciences, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]},{"name":"Laboratory of Research in Toxicology, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"de Athayde Saul","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Toxicology, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]},{"name":"Graduate Program in Pathology, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo","family":"Sander de Abreu","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"Salgado Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Toxicology, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]},{"name":"Department of Speech Therapy, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-2080","authenticated-orcid":false,"given":"Eliane","family":"Dallegrave","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]},{"name":"Laboratory of Research in Toxicology, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]},{"name":"Graduate Program in Pathology, Federal University of Health Science of Porto Alegre , Porto Alegre,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"2025093001520898700_vgaf161-B1","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1242\/jeb.087635","article-title":"Auditory sensitivity of larval zebrafish (Danio rerio) measured using a behavioral prepulse 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