{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:09:38Z","timestamp":1791670178797,"version":"4.3.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"40","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nazarzadeh","award":["FS\/19\/36\/34346"],"award-info":[{"award-number":["FS\/19\/36\/34346"]}]},{"name":"Pinho-Gomes","award":["FS\/19\/64\/34673"],"award-info":[{"award-number":["FS\/19\/64\/34673"]}]},{"name":"Rahimi","award":["PG\/18\/65\/33872"],"award-info":[{"award-number":["PG\/18\/65\/33872"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health Research (NIHR) Oxford Biomedical Research Centre"},{"name":"Oxford Martin School"},{"name":"PEAK Urban"},{"name":"UKRI\u2019s Global Challenge Research Fund","award":["ES\/P011055\/1"],"award-info":[{"award-number":["ES\/P011055\/1"]}]},{"name":"George Davey Smith"},{"name":"Medical Research Council Integrative Epidemiology Unit at the University of Bristol","award":["MC_UU_00011\/1"],"award-info":[{"award-number":["MC_UU_00011\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\u2003<\/jats:title>\n                    <jats:p>Aortic valve stenosis is commonly considered a degenerative disorder with no recommended preventive intervention, with only valve replacement surgery or catheter intervention as treatment options. We sought to assess the causal association between exposure to lipid levels and risk of aortic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results\u2003<\/jats:title>\n                    <jats:p>Causality of association was assessed using two-sample Mendelian randomization framework through different statistical methods. We retrieved summary estimations of 157 genetic variants that have been shown to be associated with plasma lipid levels in the Global Lipids Genetics Consortium that included 188\u2009577 participants, mostly European ancestry, and genetic association with aortic stenosis as the main outcome from a total of 432\u2009173 participants in the UK Biobank. Secondary negative control outcomes included aortic regurgitation and mitral regurgitation. The odds ratio for developing aortic stenosis per unit increase in lipid parameter was 1.52 [95% confidence interval (CI) 1.22\u20131.90; per 0.98\u2009mmol\/L] for low density lipoprotein (LDL)-cholesterol, 1.03 (95% CI 0.80\u20131.31; per 0.41\u2009mmol\/L) for high density lipoprotein (HDL)-cholesterol, and 1.38 (95% CI 0.92\u20132.07; per 1\u2009mmol\/L) for triglycerides. There was no evidence of a causal association between any of the lipid parameters and aortic or mitral regurgitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u2003<\/jats:title>\n                    <jats:p>Lifelong exposure to high LDL-cholesterol increases the risk of symptomatic aortic stenosis, suggesting that LDL-lowering treatment may be effective in its prevention.<\/jats:p>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa070","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T15:12:26Z","timestamp":1580310746000},"page":"3913-3920","source":"Crossref","is-referenced-by-count":153,"title":["Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization 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