{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:41:37Z","timestamp":1792885297753,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"publisher","award":["MIP-049\/2015"],"award-info":[{"award-number":["MIP-049\/2015"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Fellowships for Research Abroad"},{"name":"Asian Sudden Cardiac Death in Heart Failure"},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council of Singapore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agency for Science, Technology, and Research Biomedical Research Council"},{"name":"Asian Network for Translational Research and Cardiovascular Trials Program"},{"name":"Boston Scientific Investigator Sponsored Research Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Recent data from national registries suggest that acute heart failure (AHF) outcomes might vary in men and women, however, it is not known whether this observation is universal. The aim of this study was to evaluate the association of biological sex and 1-year all-cause mortality in patients with AHF in various regions of the world.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We analysed several AHF cohorts including GREAT registry (22\u2009523 patients, mostly from Europe and Asia) and OPTIMIZE-HF (26\u2009376 patients from the USA). Clinical characteristics and medication use at discharge were collected. Hazard ratios (HRs) for 1-year mortality according to biological sex were calculated using a Cox proportional hazards regression model with adjustment for baseline characteristics (e.g. age, comorbidities, clinical and laboratory parameters at admission, left ventricular ejection fraction). In the GREAT registry, women had a lower risk of death in the year following AHF [HR 0.86 (0.79\u20130.94), P\u2009&amp;lt;\u20090.001 after adjustment]. This was mostly driven by northeast Asia [n\u2009=\u20099135, HR 0.76 (0.67\u20130.87), P\u2009&amp;lt;\u20090.001], while no significant differences were seen in other countries. In the OPTIMIZE-HF registry, women also had a lower risk of 1-year death [HR 0.93 (0.89\u20130.97), P\u2009&amp;lt;\u20090.001]. In the GREAT registry, women were less often prescribed with a combination of angiotensin-converting enzyme inhibitors and beta-blockers at discharge (50% vs. 57%, P\u2009=\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Globally women with AHF have a lower 1-year mortality and less evidenced-based treatment than men. Differences among countries need further investigation. Our findings merit consideration when designing future global clinical trials in AHF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa071","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T04:31:14Z","timestamp":1580790674000},"page":"1357-1364","source":"Crossref","is-referenced-by-count":69,"title":["The association of long-term outcome and biological sex in patients with acute heart failure from different geographic regions"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8385-528X","authenticated-orcid":false,"given":"Justina","family":"Motiej\u016bnait\u0117","sequence":"first","affiliation":[{"name":"Inserm UMR-S 942 MASCOT, H\u00f4pital Lariboisi\u00e8re - B\u00e2timent Viggo Petersen 41 , boulevard de la Chapelle, 75475 Paris Cedex 10, France"},{"name":"Department of Anesthesiology and Critical Care, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris , 2 Rue Ambroise Par\u00e9, 75010 Paris, France"},{"name":"Department of Cardiology, Lithuanian University of Health Sciences Kaunas Clinics , 2 Eiveni\u0173 street 2 LT-50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7333-1909","authenticated-orcid":false,"given":"Eiichi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Inserm UMR-S 942 MASCOT, H\u00f4pital Lariboisi\u00e8re - B\u00e2timent Viggo Petersen 41 , boulevard de la Chapelle, 75475 Paris Cedex 10, France"},{"name":"Division of Cardiology, Yokohama City University Medical Center, 4 Chome\u221257 , \u3012 232-0024 Kanagawa, Yokohama, Minami Ward, Urafunecho, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1055-2231","authenticated-orcid":false,"given":"Alain","family":"Cohen-Solal","sequence":"additional","affiliation":[{"name":"Inserm UMR-S 942 MASCOT, H\u00f4pital Lariboisi\u00e8re - B\u00e2timent Viggo Petersen 41 , boulevard de la Chapelle, 75475 Paris Cedex 10, France"},{"name":"Department of Cardiology, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris , 2 Rue Ambroise Par\u00e9, 75010 Paris, France"},{"name":"Universit\u00e9 de Paris, 16 Rue Henri Huchard , 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-6779","authenticated-orcid":false,"given":"Aldo Pietro","family":"Maggioni","sequence":"additional","affiliation":[{"name":"ANMCO Research Center, Via Alfonso la Marmora , 36, 50121 Firenze FI, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-6405","authenticated-orcid":false,"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel , Spitalstrasse 21, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-2189","authenticated-orcid":false,"given":"Dong-Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital , 101 Daehak-Ro, Jongno-gu, Seoul 03080, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Au\u0161ra","family":"Kavoli\u016bnien\u0117","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lithuanian University of Health Sciences Kaunas Clinics , 2 Eiveni\u0173 street 2 LT-50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"\u010celutkien\u0117","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Vilnius University , 2 Santariskiu Street, LT-08661 Bilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Parenica","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Brno and Medical Faculty, Masaryk University , Kamenice 5, 625 00 Bohunice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lassus","sequence":"additional","affiliation":[{"name":"Cardiology, Division of Cardiology, Heart and Lung Center, Helsinki University Hospital, Helsinki University , Haartmaninkatu 4 Rakennus 1, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2812-0739","authenticated-orcid":false,"given":"Katsuya","family":"Kajimoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Sekikawa Hospital, 1 Chome-4-1 Nishinippori , Arakawa City, Tokyo 116-0013, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-0083","authenticated-orcid":false,"given":"Naoki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Intensive Care Unit, Nippon Medical School Musashi-Kosugi Hospital , 1 Chome-396 Kosugimachi, Nakahara Ward, Kawasaki, Kanagawa 211-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-9751","authenticated-orcid":false,"given":"\u00d2scar","family":"Mir\u00f3","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Clinic and \u201cEmergencies: Processes and Pathologies\u201d Research Group , IDIBAPS, Carrer del Rossell\u00f3, 149, 08036 Barcelona, Spain"},{"name":"University of Barcelona, Gran Via de les Corts Catalanes , 585 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Frank","family":"Peacock","sequence":"additional","affiliation":[{"name":"Emergency Department, Baylor College of Medicine , 1 Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-8525","authenticated-orcid":false,"given":"Yuya","family":"Matsue","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Juntendo University , 3 Chome-1-\u756a3\u53f7 Hongo, Bunkyo City, Tokyo 113-8431, Japan"},{"name":"Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine , 3 Chome-1-\u756a3\u53f7 Hongo, Bunkyo City, Tokyo 113-8431, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A","family":"Voors","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn S P","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen, the Netherlands"},{"name":"National Heart Centre , 5 Hospital Dr, Singapore 169609, Singapore"},{"name":"Duke-National University of Singapore , 8 College Rd, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-4086","authenticated-orcid":false,"given":"Justin A","family":"Ezekowitz","sequence":"additional","affiliation":[{"name":"Canadian VIGOUR Centre, Katz Group Centre for Pharmacy and Health Research, University of Alberta , 4-120, Edmonton, AB T6G, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Health and Aging, Veterans Affairs Medical Center, George Washington University , 2121 I St NW, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-8093","authenticated-orcid":false,"given":"Gregg C","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California , Los Angeles, 100 Medical Plaza Driveway, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3334-3849","authenticated-orcid":false,"given":"Etienne","family":"Gayat","sequence":"additional","affiliation":[{"name":"Inserm UMR-S 942 MASCOT, H\u00f4pital Lariboisi\u00e8re - B\u00e2timent Viggo Petersen 41 , boulevard de la Chapelle, 75475 Paris Cedex 10, France"},{"name":"Department of Anesthesiology and Critical Care, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris , 2 Rue Ambroise Par\u00e9, 75010 Paris, France"},{"name":"Universit\u00e9 de Paris, 16 Rue Henri Huchard , 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-3467","authenticated-orcid":false,"given":"Vera","family":"Regitz-Zagrosek","sequence":"additional","affiliation":[{"name":"Center for Gender in Medicine (GIM), Center for Cardiovascular Research, (CCR), Charite - Universitaetsmedizin Berlin , DZHK Partner Site Berlin, Charit\u00e9pl. 1, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"Inserm UMR-S 942 MASCOT, H\u00f4pital Lariboisi\u00e8re - B\u00e2timent Viggo Petersen 41 , boulevard de la Chapelle, 75475 Paris Cedex 10, France"},{"name":"Department of Anesthesiology and Critical Care, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris , 2 Rue Ambroise Par\u00e9, 75010 Paris, France"},{"name":"Universit\u00e9 de Paris, 16 Rue Henri Huchard , 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"2022101805361640500_ehaa071-B1","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics\u20142017 update: a report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"2022101805361640500_ehaa071-B2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejheart.2007.12.012","article-title":"Gender related differences in patients presenting with acute heart failure. 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Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2022101805361640500_ehaa071-B9","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2022101805361640500_ehaa071-B10","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.amjcard.2017.02.012","article-title":"Acute decompensated heart failure syndromes r. gender differences in left ventricular ejection fraction and outcomes among patients hospitalized for acute decompensated heart failure","volume":"119","author":"Kajimoto","year":"2017","journal-title":"Am J 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