{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:59:13Z","timestamp":1793383153981,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"33","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770885"],"award-info":[{"award-number":["81770885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Basic Research","award":["201605303000678"],"award-info":[{"award-number":["201605303000678"]}]},{"name":"Collaborative Research Fund","award":["C7037-17W"],"award-info":[{"award-number":["C7037-17W"]}]},{"name":"Area of Excellence Scheme","award":["AOE\/M-707\/18"],"award-info":[{"award-number":["AOE\/M-707\/18"]}]},{"name":"Hong Kong Special Administrative Region, Science and Technology Major Project of Hunan Province","award":["2017SK1020"],"award-info":[{"award-number":["2017SK1020"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC13000604"],"award-info":[{"award-number":["2016YFC13000604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation and Technology Commission-FASII","award":["GHP\/079\/18SZ"],"award-info":[{"award-number":["GHP\/079\/18SZ"]}]},{"name":"Shenzhen-Hong Kong Joint Research Program","award":["SGLH20180625142404672"],"award-info":[{"award-number":["SGLH20180625142404672"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Adipocyte fatty acid-binding protein (A-FABP) is an adipokine implicating in various metabolic diseases. Elevated circulating levels of A-FABP correlate positively with poor prognosis in ischaemic stroke (IS) patients. No information is available concerning the role of A-FABP in the pathogenesis of IS. Experiments were designed to determine whether or not A-FABP mediates blood\u2013brain barrier (BBB) disruption, and if so, to explore the molecular mechanisms underlying this deleterious effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Circulating A-FABP and its cerebral expression were increased in mice after middle cerebral artery occlusion. Genetic deletion and pharmacological inhibition of A-FABP alleviated cerebral ischaemia injury with reduced infarction volume, cerebral oedema, neurological deficits, and neuronal apoptosis; BBB disruption was attenuated and accompanied by reduced degradation of tight junction proteins and induction of matrix metalloproteinases-9 (MMP-9). In patients with acute IS, elevated circulating A-FABP levels positively correlated with those of MMP-9 and cerebral infarct volume. Mechanistically, ischaemia-induced elevation of A-FABP selectively in peripheral blood monocyte-derived macrophages and cerebral resident microglia promoted MMP-9 transactivation by potentiating JNK\/c-Jun signalling, enhancing degradation of tight junction proteins and BBB leakage. The detrimental effects of A-FABP were prevented by pharmacological inhibition of MMP-9.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A-FABP is a key mediator of cerebral ischaemia injury promoting MMP-9-mediated BBB disruption. Inhibition of A-FABP is a potential strategy to improve IS outcome.<\/jats:p>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa207","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T12:39:35Z","timestamp":1583930375000},"page":"3169-3180","source":"Crossref","is-referenced-by-count":108,"title":["Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood\u2013brain barrier"],"prefix":"10.1093","volume":"41","author":[{"given":"Boya","family":"Liao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiluo","family":"Geng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , No. 107, Yanjiang Road West, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-8563","authenticated-orcid":false,"given":"Lingling","family":"Shu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory on Cognition and Neuropsychiatric Disorders , No. 218, Jixi Road, Hefei, Anhui Province 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick K K","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-541X","authenticated-orcid":false,"given":"Karen S L","family":"Lam","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sookja K","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Macau University of Science and Technology, Avenida Wai Long , Taipa 999078, Macau, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-9022","authenticated-orcid":false,"given":"Junlei","family":"Chang","sequence":"additional","affiliation":[{"name":"Centre for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , No. 1068, Xueyuan Blvd, Xili Nanshan, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M","family":"Vanhoutte","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark , Campusvej 55, Odense 5230, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong, China"},{"name":"Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong 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