{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:41:56Z","timestamp":1794433316679,"version":"4.9.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"39","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Abbott Vascular Int."},{"name":"The Bristol Myers Squibb and Pfizer Alliance"},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2016-StG-715732"],"award-info":[{"award-number":["ERC-2016-StG-715732"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"British Heart Foundation Centre of Excellence Research Grant","award":["18\/6\/34217"],"award-info":[{"award-number":["18\/6\/34217"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>We sought to describe the clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy (PPCM) globally.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>In 2011, &amp;gt;100 national and affiliated member cardiac societies of the European Society of Cardiology (ESC) were contacted to contribute to a global registry on PPCM, under the auspices of the ESC EURObservational Research Programme. These societies were tasked with identifying centres who could participate in this registry. In low-income countries, e.g. Mozambique or Burkina Faso, where there are no national societies due to a shortage of cardiologists, we identified potential participants through abstracts and publications and encouraged participation into the study. Seven hundred and thirty-nine women were enrolled in 49 countries in Europe (33%), Africa (29%), Asia-Pacific (15%), and the Middle East (22%). Mean age was 31\u2009\u00b1\u20096\u2009years, mean left ventricular ejection fraction (LVEF) was 31\u2009\u00b1\u200910%, and 10% had a previous pregnancy complicated by PPCM. Symptom-onset occurred most often within 1\u2009month of delivery (44%). At diagnosis, 67% of patients had severe (NYHA III\/IV) symptoms and 67% had a LVEF \u226435%. Fifteen percent received bromocriptine with significant regional variation (Europe 15%, Africa 26%, Asia-Pacific 8%, the Middle East 4%, P\u2009&amp;lt;\u20090.001). Follow-up was available for 598 (81%) women. Six-month mortality was 6% overall, lowest in Europe (4%), and highest in the Middle East (10%). Most deaths were due to heart failure (42%) or sudden (30%). Re-admission for any reason occurred in 10% (with just over half of these for heart failure) and thromboembolic events in 7%. Myocardial recovery (LVEF &amp;gt; 50%) occurred only in 46%, most commonly in Asia-Pacific (62%), and least commonly in the Middle East (25%). Neonatal death occurred in 5% with marked regional variation (Europe 2%, the Middle East 9%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion\u2003<\/jats:title>\n                  <jats:p>Peripartum cardiomyopathy is a global disease, but clinical presentation and outcomes vary by region. Just under half of women experience myocardial recovery. Peripartum cardiomyopathy is a disease with substantial maternal and neonatal morbidity and mortality.<\/jats:p>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa455","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T11:56:57Z","timestamp":1589371017000},"page":"3787-3797","source":"Crossref","is-referenced-by-count":184,"title":["Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-0911","authenticated-orcid":false,"given":"Karen","family":"Sliwa","sequence":"first","affiliation":[{"name":"Department of Medicine and Cardiology, Hatter Institute for Cardiovascular Research in Africa, University of Cape Town , Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-9496","authenticated-orcid":false,"given":"Mark C","family":"Petrie","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow , Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-4413","authenticated-orcid":false,"given":"Peter","family":"van der Meer","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen Department of Cardiology, , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"UMRS 942 Inserm-MASCOT Unit, Universit\u00e9 de Paris, H\u00f4pitaux Universitaires Saint-Louis-Lariboisi\u00e8re , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6065-9649","authenticated-orcid":false,"given":"Denise","family":"Hilfiker-Kleiner","sequence":"additional","affiliation":[{"name":"Medical School Hannover Department of Cardiology and Angiology, , Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M","family":"Jackson","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow , Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-6779","authenticated-orcid":false,"given":"Aldo P","family":"Maggioni","sequence":"additional","affiliation":[{"name":"EurObservational Research Programme, European Society of Cardiology, Sophie Antipolis , France"},{"name":"ANMCO Research Centre , Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Laroche","sequence":"additional","affiliation":[{"name":"EurObservational Research Programme, European Society of Cardiology, Sophie Antipolis , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-3467","authenticated-orcid":false,"given":"Vera","family":"Regitz-Zagrosek","sequence":"additional","affiliation":[{"name":"Berlin Institute of Gender in Medicine (GiM), Charit\u00e9\u2014Universit\u00e4tsmedizin , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Schaufelberger","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Sahlgrenska Academy, University of Gothenburg Department of Molecular and Clinical Medicine, , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, GVM Care & Research , Cotignola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-3830","authenticated-orcid":false,"given":"Jolien W","family":"Roos-Hesselink","sequence":"additional","affiliation":[{"name":"Thoraxcenter, Erasmus Medical Center Department Cardiology, , Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-4199","authenticated-orcid":false,"given":"Petar","family":"Seferovic","sequence":"additional","affiliation":[{"name":"University of Belgrade Faculty of Medicine , Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-0404","authenticated-orcid":false,"given":"Karin","family":"van Spaendonck-Zwarts","sequence":"additional","affiliation":[{"name":"University of Amsterdam Department of Genetics, Academic Medical Center, , Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-9042","authenticated-orcid":false,"given":"Amam","family":"Mbakwem","sequence":"additional","affiliation":[{"name":"College of Medicine and Lagos University Teaching Hospital Department of Medicine, , Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes , Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Mouquet","sequence":"additional","affiliation":[{"name":"H\u00f4pital priv\u00e9 le Bois , LilleService de Cardiologie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Department of Cardiology, , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-9918","authenticated-orcid":false,"given":"Mark R","family":"Johnson","sequence":"additional","affiliation":[{"name":"Imperial College School of Medicine, Chelsea and Westminster Hospital Department of Obstetrics, , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Righab","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Beirut Cardiac Institute Department of Cardiology, , Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Warsaw Medical University , Warsaw, 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