{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:18:01Z","timestamp":1793132281709,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"29","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Institute of Valvular Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Due to bioprosthetic valve degeneration, aortic valve-in-valve (ViV) procedures are increasingly performed. There are no data on long-term outcomes after aortic ViV. Our aim was to perform a large-scale assessment of long-term survival and reintervention after aortic ViV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 1006 aortic ViV procedures performed more than 5 years ago [mean age 77.7\u2009\u00b1\u20099.7 years; 58.8% male; median STS-PROM score 7.3% (4.2\u201312.0)] were included in the analysis. Patients were treated with Medtronic self-expandable valves (CoreValve\/Evolut, Medtronic Inc., Minneapolis, MN, USA) (n\u2009=\u2009523, 52.0%), Edwards balloon-expandable valves (EBEV, SAPIEN\/SAPIEN XT\/SAPIEN 3, Edwards Lifesciences, Irvine, CA, USA) (n\u2009=\u2009435, 43.2%), and other devices (n\u2009=\u200948, 4.8%). Survival was lower at 8 years in patients with small-failed bioprostheses [internal diameter (ID) \u2264 20 mm] compared with those with large-failed bioprostheses (ID &amp;gt; 20 mm) (33.2% vs. 40.5%, P\u2009=\u20090.01). Independent correlates for mortality included smaller-failed bioprosthetic valves [hazard ratio (HR) 1.07 (95% confidence interval (CI) 1.02\u20131.13)], age [HR 1.21 (95% CI 1.01\u20131.45)], and non-transfemoral access [HR 1.43 (95% CI 1.11\u20131.84)]. There were 40 reinterventions after ViV. Independent correlates for all-cause reintervention included pre-existing severe prosthesis\u2013patient mismatch [subhazard ratio (SHR) 4.34 (95% CI 1.31\u201314.39)], device malposition [SHR 3.75 (95% CI 1.36\u201310.35)], EBEV [SHR 3.34 (95% CI 1.26\u20138.85)], and age [SHR 0.59 (95% CI 0.44\u20130.78)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The size of the original failed valve may influence long-term mortality, and the type of the transcatheter valve may influence the need for reintervention after aortic ViV.<\/jats:p>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa544","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T15:40:22Z","timestamp":1592840422000},"page":"2731-2742","source":"Crossref","is-referenced-by-count":156,"title":["Long-term outcomes after transcatheter aortic valve implantation in failed bioprosthetic valves"],"prefix":"10.1093","volume":"41","author":[{"given":"Sabine","family":"Bleiziffer","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Thorax- und Kardiovaskularchirurgie, Herz- und Diabeteszentrum Nordrhein-Westfalen , Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-8751","authenticated-orcid":false,"given":"Matheus","family":"Simonato","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Escola Paulista de Medicina - Universidade Federal de S\u00e3o Paulo , R. Botucatu, 740, S\u00e3o Paulo - SP, 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Webb","sequence":"additional","affiliation":[{"name":"Centre for Heart Valve Innovation, St. Paul's Hospital, University of British Columbia , 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , 1050 Avenue de la M\u00e9decine Local 4211 Ferdinand Vandry Pavillon, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":false,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , 1050 Avenue de la M\u00e9decine Local 4211 Ferdinand Vandry Pavillon, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rabin Medical Center, Beilinson Hospital in Petach Tikva & Faculty of Medicine at Tel Aviv University , 39 Jabotinski St., Petah Tikva 49100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-6762","authenticated-orcid":false,"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Kardiologie, Inselspital Bern , Freiburgstrasse 15 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Erlebach","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz- und Gef\u00e4\u00dfchirurgie, Deutsches Herzzentrum M\u00fcnchen , Lazarettstra\u00dfe 36, 80636 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, The Royal Brompton Hospital , Sydney Street, London, SW3 6NP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Seiffert","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Herz- und Gef\u00e4\u00dfzentrum, Universit\u00e4tsklinikum Hamburg-Eppendorf , Villa Garbrecht, Martinistra\u00dfe 52, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Unbehaun","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz-, Thorax- und Gef\u00e4\u00dfchirurgie, Deutsches Herzzentrum Berlin , Augustenburger Platz 1 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Frerker","sequence":"additional","affiliation":[{"name":"Klinik III f\u00fcr Innere Medizin, Uniklinik K\u00f6ln, K\u00f6ln , Kerpener Str. 62, 50937 K\u00f6ln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Conzelmann","sequence":"additional","affiliation":[{"name":"Helios Klinik f\u00fcr Herzchirurgie Karlsruhe , Helios Karlsruhe, Franz-Lust-Stra\u00dfe 30, 76185 Karlsruhe, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harindra","family":"Wijeysundera","sequence":"additional","affiliation":[{"name":"Schulich Heart Centre, Sunnybrook Health Sciences Centre , 2075 Bayview Ave. Toronto, ON M4N 3M5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-7478","authenticated-orcid":false,"given":"Won-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Kardiologie, Kerckhoff-Klinik , Benekestr. 2 - 8, 61231 Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-9459","authenticated-orcid":false,"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Cardiologia Interventistica ed Emodinamica , I.R.C.C.S. 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