{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:47:49Z","timestamp":1790948869847,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"37","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Group","award":["KFO311"],"award-info":[{"award-number":["KFO311"]}]},{"name":"Excellence Cluster REBIRTH-2","award":["TH2161\/1-1"],"award-info":[{"award-number":["TH2161\/1-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\u2003<\/jats:title>\n                    <jats:p>Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission tomography (PET) and establish its relationship to cardiac outcome. We tested whether image-guided early CXCR4 directed therapy attenuates chronic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results\u2003<\/jats:title>\n                    <jats:p>Mice (n\u2009=\u2009180) underwent coronary ligation or sham surgery and serial PET imaging over 7 days. Infarct CXCR4 content was elevated over 3 days after MI compared with sham (%ID\/g, Day 1:1.1\u2009\u00b1\u20090.2; Day 3:0.9\u2009\u00b1\u20090.2 vs. 0.6\u2009\u00b1\u20090.1, P\u2009&amp;lt;\u20090.001), confirmed by flow cytometry and histopathology. Mice that died of left ventricle (LV) rupture exhibited persistent inflammation at 3 days compared with survivors (1.2\u2009\u00b1\u20090.3 vs. 0.9\u2009\u00b1\u20090.2% ID\/g, P\u2009&amp;lt;\u20090.001). Cardiac magnetic resonance measured cardiac function. Higher CXCR4 signal at 1 and 3 days independently predicted worse functional outcome at 6 weeks (r \u00a0partial = \u22120.4, P\u2009=\u20090.04). Mice were treated with CXCR4 blocker AMD3100 following the imaging timecourse. On-peak CXCR4 blockade at 3 days lowered LV rupture incidence vs. untreated MI (8% vs. 25%), and improved contractile function at 6 weeks (+24%, P\u2009=\u20090.01). Off-peak CXCR4 blockade at 7 days did not improve outcome. Flow cytometry analysis revealed lower LV neutrophil and Ly6Chigh monocyte content after on-peak treatment. Patients (n\u2009=\u200950) early after MI underwent CXCR4 PET imaging and functional assessment. Infarct CXCR4 expression in acute MI patients correlated with contractile function at time of PET and on follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u2003<\/jats:title>\n                    <jats:p>Positron emission tomography imaging identifies early CXCR4 up-regulation which predicts acute rupture and chronic contractile dysfunction. Imaging-guided CXCR4 inhibition accelerates inflammatory resolution and improves outcome. This supports a molecular imaging-based theranostic approach to guide therapy after MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa598","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T15:13:22Z","timestamp":1593702802000},"page":"3564-3575","source":"Crossref","is-referenced-by-count":88,"title":["Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-2595","authenticated-orcid":false,"given":"Annika","family":"Hess","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Hannover Medical School , Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8786-4105","authenticated-orcid":false,"given":"Thorsten","family":"Derlin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hannover Medical School , Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Koenig","sequence":"additional","affiliation":[{"name":"D \u00a0 , Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"epartment of Cardiology and Angiology \u00a0 , Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-3601","authenticated-orcid":false,"given":"Johanna","family":"Diekmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hannover Medical School , Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Wittneben","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hannover Medical School , Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"D \u00a0 , Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"epartment of Cardiology and Angiology \u00a0 , Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Juergen","family":"Wester","sequence":"additional","affiliation":[{"name":"Radiopharmaceutical Chemistry, Technical University of Munich , Walther-Meissner-Str. 3, 85748 Garching, 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