{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:56:57Z","timestamp":1793555817921,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"42","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL094301-07"],"award-info":[{"award-number":["T32HL094301-07"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL094301"],"award-info":[{"award-number":["T32 HL094301"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>There are sex differences in presentation, treatment, and outcomes of myocardial infarction (MI) but less is known about these differences in a younger patient population. The objective of this study was to investigate sex differences among individuals who experience their first MI at a young age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive patients presenting to two large academic medical centres with a Type 1 MI at \u226450\u2009years of age between 2000 and 2016 were included. Cause of death was adjudicated using electronic health records and death certificates. In total, 2097 individuals (404 female, 19%) had an MI (mean age 44\u2009\u00b1\u20095.1\u2009years, 73% white). Risk factor profiles were similar between men and women, although women were more likely to have diabetes (23.7% vs. 18.9%, P\u2009=\u20090.028). Women were less likely to undergo invasive coronary angiography (93.5% vs. 96.7%, P\u2009=\u20090.003) and coronary revascularization (82.1% vs. 92.6%, P\u2009&amp;lt;\u20090.001). Women were significantly more likely to have MI with non-obstructive coronary disease on angiography (10.2% vs. 4.2%, P\u2009&amp;lt;\u20090.001). They were less likely to be discharged with aspirin (92.2% vs. 95.0%, P\u2009=\u20090.027), beta-blockers (86.6% vs. 90.3%, P\u2009=\u20090.033), angiotensin-converting enzyme inhibitors\/angiotensin-receptor blockers (53.4% vs. 63.7%, P\u2009&amp;lt;\u20090.001), and statins (82.4% vs. 88.4%, P\u2009&amp;lt;\u20090.001). There was no significant difference in in-hospital mortality; however, women who survived to hospital discharge experienced a higher all-cause mortality rate (adjusted HR\u2009=\u20091.63, P\u2009=\u20090.01; median follow-up 11.2\u2009years) with no significant difference in cardiovascular mortality (adjusted HR = 1.14, P\u2009=\u20090.61).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Women who experienced their first MI under the age of 50 were less likely to undergo coronary revascularization or be treated with guideline-directed medical therapies. Women who survived hospitalization experienced similar cardiovascular mortality with significantly higher all-cause mortality than men. A better understanding of the mechanisms underlying these differences is warranted.<\/jats:p>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa662","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T19:30:43Z","timestamp":1596569443000},"page":"4127-4137","source":"Crossref","is-referenced-by-count":134,"title":["Women who experience a myocardial infarction at a young age have worse outcomes compared with men: the Mass General Brigham YOUNG-MI registry"],"prefix":"10.1093","volume":"41","author":[{"given":"Ersilia M","family":"DeFilippis","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis Street, Boston 02115, MA, USA"},{"name":"New York Presbyterian-Columbia University Irving Medical Center , New York City, New York, NY, 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