{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:23:01Z","timestamp":1793834581317,"version":"4.6.1"},"reference-count":123,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Texas Heart Institute in Houston"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cardiovascular diseases (CVDs), specifically lipid-driven atherosclerotic CVDs, remain the number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1), a scavenger receptor that promotes endothelial dysfunction by inducing pro-atherogenic signalling and plaque formation via the endothelial uptake of oxidized LDL (oxLDL) and electronegative LDL, contributes to the initiation, progression, and destabilization of atheromatous plaques, eventually leading to the development of myocardial infarction and certain forms of stroke. In addition to its expression in endothelial cells, LOX-1 is expressed in macrophages, cardiomyocytes, fibroblasts, dendritic cells, lymphocytes, and neutrophils, further implicating this receptor in multiple aspects of atherosclerotic plaque formation. LOX-1 holds promise as a novel diagnostic and therapeutic target for certain CVDs; therefore, understanding the molecular structure and function of LOX-1 is of critical importance. In this review, we highlight the latest scientific findings related to LOX-1, its ligands, and their roles in the broad spectrum of CVDs. We describe recent findings from basic research, delineate their translational value, and discuss the potential of LOX-1 as a novel target for the prevention, diagnosis, and treatment of related CVDs.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehaa770","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T19:14:44Z","timestamp":1599506084000},"page":"1797-1807","source":"Crossref","is-referenced-by-count":150,"title":["Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-9493","authenticated-orcid":false,"given":"Alexander","family":"Akhmedov","sequence":"first","affiliation":[{"name":"Center for Molecular Cardiology, University of Zurich , Wagistreet 12, Schlieren 8952, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-2080","authenticated-orcid":false,"given":"Tatsuya","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathophysiology, Shinshu University School of Medicine, Shinshu University 3-1-1 , Asahi, Matsumoto 390-8621, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1509-7883","authenticated-orcid":false,"given":"Chu-Huang","family":"Chen","sequence":"additional","affiliation":[{"name":"Vascular and Medical Research, Texas Heart Institute , 6770 Bertner Avenue, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-7287","authenticated-orcid":false,"given":"Simon","family":"Kraler","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, University of Zurich , Wagistreet 12, Schlieren 8952, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1236-3290","authenticated-orcid":false,"given":"Daria","family":"Vdovenko","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, University of Zurich , Wagistreet 12, Schlieren 8952, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, University of Zurich , Wagistreet 12, Schlieren 8952, Switzerland"},{"name":"Royal Brompton and Harefield Hospitals , Sydney Street, London SW3 6NP, UK"},{"name":"National Heart and Lung Institute, Imperial College , Dovehause Street, London SW3 6LY, 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