{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:42:22Z","timestamp":1793742142437,"version":"4.6.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011083","name":"Centre for Heart Rhythm Disorders","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011083","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Hospital Research Fund"},{"name":"National Health and Medical Research Council of Australia"},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Our objective was to determine the ventricular arrhythmia burden in implantable cardioverter-defibrillator (ICD) patients during COVID-19.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In this multicentre, observational, cohort study over a 100-day period during the COVID-19 pandemic in the USA, we assessed ventricular arrhythmias in ICD patients from 20 centres in 13 states, via remote monitoring. Comparison was via a 100-day control period (late 2019) and seasonal control period (early 2019). The primary outcome was the impact of COVID-19 on ventricular arrhythmia burden. The secondary outcome was correlation with COVID-19 incidence. During the COVID-19 period, 5963 ICD patients underwent remote monitoring, with 16 942 episodes of treated ventricular arrhythmias (2.8 events per 100 patient-days). Ventricular arrhythmia burden progressively declined during COVID-19 (P &amp;lt; 0.001). The proportion of patients with ventricular arrhythmias amongst the high COVID-19 incidence states was significantly reduced compared with those in low incidence states [odds ratio 0.61, 95% confidence interval (CI) 0.54\u20130.69, P &amp;lt; 0.001]. Comparing patients remotely monitored during both COVID-19 and control periods (n = 2458), significantly fewer ventricular arrhythmias occurred during COVID-19 [incident rate ratio (IRR) 0.68, 95% CI 0.58\u20130.79, P &amp;lt; 0.001]. This difference persisted when comparing the 1719 patients monitored during both the COVID-19 and seasonal control periods (IRR 0.69, 95% CI 0.56\u20130.85, P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>During COVID-19, there was a 32% reduction in ventricular arrhythmias needing device therapies, coinciding with measures of social isolation. There was a 39% reduction in the proportion of patients with ventricular arrhythmias in states with higher COVID-19 incidence. These findings highlight the potential role of real-life stressors in ventricular arrhythmia burden in individuals with ICDs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration<\/jats:title>\n                  <jats:p>Australian New Zealand Clinical Trial Registry; URL: https:\/\/www.anzctr.org.au\/; Unique Identifier: ACTRN12620000641998<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa893","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:46:53Z","timestamp":1602636413000},"page":"520-528","source":"Crossref","is-referenced-by-count":50,"title":["Ventricular arrhythmia burden during the coronavirus disease 2019 (COVID-19) pandemic"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-6106","authenticated-orcid":false,"given":"Catherine J","family":"O\u2019Shea","sequence":"first","affiliation":[{"name":"Centre for Heart 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian D","family":"Elliott","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders, University of Adelaide , Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-5202","authenticated-orcid":false,"given":"Noemi","family":"Ray","sequence":"additional","affiliation":[{"name":"PaceMate , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7753-1318","authenticated-orcid":false,"given":"Dennis H","family":"Lau","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders, University of Adelaide , Adelaide, Australia"},{"name":"Department of Cardiology, Royal Adelaide Hospital , Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Campbell","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm 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