{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:36Z","timestamp":1792794096110,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health"},{"name":"IRCCS Policlinico San Donato","id":[{"id":"https:\/\/ror.org\/01220jp31","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\u2003<\/jats:title>\n                    <jats:p>Brugada syndrome (BrS) is associated with an increased risk of sudden cardiac death due to ventricular tachycardia\/fibrillation (VT\/VF) in young, otherwise healthy individuals. Despite SCN5A being the most commonly known mutated gene to date, the genotype\u2013phenotype relationship is poorly understood and remains uncertain. This study aimed to elucidate the genotype\u2013phenotype correlation in BrS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Brugada syndrome probands deemed at high risk of future arrhythmic events underwent genetic testing and phenotype characterization by the means of epicardial arrhythmogenic substrate (AS) mapping, and were divided into two groups according to the presence or absence of SCN5A mutation. Two-hundred probands (160 males, 80%; mean age 42.6 \u00b1 12.2 years) were included in this study. Patients harbouring SCN5A mutations exhibited a spontaneous type 1 pattern and experienced aborted cardiac arrest or spontaneous VT\/VF more frequently than the other subjects. SCN5A-positive patients exhibited a larger epicardial AS area, more prolonged electrograms and more frequently observed non-invasive late potentials. The presence of an SCN5A mutation explained &amp;gt;26% of the variation in the epicardial AS area and was the strongest predictor of a large epicardial area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u2003<\/jats:title>\n                    <jats:p>In BrS, the genetic background is the main determinant for the extent of the electrophysiological abnormalities. SCN5A mutation carriers exhibit more pronounced epicardial electrical abnormalities and a more aggressive clinical presentation. These results contribute to the understanding of the genetic determinants of the BrS phenotypic expression and provide possible explanations for the varying degrees of disease expression.<\/jats:p>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaa942","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T07:09:13Z","timestamp":1604300953000},"page":"1082-1090","source":"Crossref","is-referenced-by-count":98,"title":["Brugada syndrome genetics is associated with phenotype severity"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-5467","authenticated-orcid":false,"given":"Giuseppe","family":"Ciconte","sequence":"first","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-7776","authenticated-orcid":false,"given":"Michelle M","family":"Monasky","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Santinelli","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-7800","authenticated-orcid":false,"given":"Emanuele","family":"Micaglio","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Vicedomini","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-2161","authenticated-orcid":false,"given":"Luigi","family":"Anastasia","sequence":"additional","affiliation":[{"name":"Stem Cells for Tissue Engineering Laboratory, IRCCS Policlinico San Donato , piazza Malan 2, 20097 San Donato Milanese, Milan, Italy"},{"name":"Vita-Salute San Raffaele University , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Negro","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-5677","authenticated-orcid":false,"given":"Valeria","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Giannelli","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Santini","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"de Innocentiis","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7143-8902","authenticated-orcid":false,"given":"Roberto","family":"Rondine","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-0455","authenticated-orcid":false,"given":"Emanuela T","family":"Locati","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-6568","authenticated-orcid":false,"given":"Beniamino C","family":"Mazza","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Mecarocci","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u017darko","family":"\u0106alovi\u0107","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-7390","authenticated-orcid":false,"given":"Andrea","family":"Ghiroldi","sequence":"additional","affiliation":[{"name":"Stem Cells for Tissue Engineering Laboratory, IRCCS Policlinico San Donato , piazza Malan 2, 20097 San Donato Milanese, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-9767","authenticated-orcid":false,"given":"Sara","family":"D\u2019Imperio","sequence":"additional","affiliation":[{"name":"Stem Cells for Tissue Engineering Laboratory, IRCCS Policlinico San Donato , piazza Malan 2, 20097 San Donato Milanese, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-3040","authenticated-orcid":false,"given":"Sara","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Clinical Genomics \u2013 SMEL, IRCCS San Raffaele Hospital , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Di Resta","sequence":"additional","affiliation":[{"name":"Vita-Salute San Raffaele University , Milan, Italy"},{"name":"Clinical Genomics \u2013 SMEL, IRCCS San Raffaele Hospital , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-9069","authenticated-orcid":false,"given":"Ilaria","family":"Rivolta","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-8980","authenticated-orcid":false,"given":"Giorgio","family":"Casari","sequence":"additional","affiliation":[{"name":"Vita-Salute San Raffaele University , Milan, Italy"},{"name":"Clinical Genomics \u2013 SMEL, IRCCS San Raffaele Hospital , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-5921","authenticated-orcid":false,"given":"Enrico","family":"Petretto","sequence":"additional","affiliation":[{"name":"Programme in Cardiovascular and Metabolic Disorders and Centre for Computational Biology, Duke-NUS Medical School Singapore , Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-6135","authenticated-orcid":false,"given":"Carlo","family":"Pappone","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato , Piazza E. Malan 1, 20097 San Donato Milanese, Milano, Italy"},{"name":"Vita-Salute San Raffaele University , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"2022102512492176500_ehaa942-B1","doi-asserted-by":"crossref","first-page":"e392","DOI":"10.1161\/CIR.0000000000000550","article-title":"Systematic review for the 2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"138","author":"Kusumoto","year":"2018","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051687","article-title":"Brugada syndrome: oligogenic or mendelian disease?","volume":"21","author":"Monasky","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2022102512492176500_ehaa942-B3","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/CIRCULATIONAHA.118.035070","article-title":"Reappraisal of reported genes for sudden arrhythmic death","volume":"138","author":"Hosseini","year":"2018","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.hrthm.2009.09.069","article-title":"An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing","volume":"7","author":"Kapplinger","year":"2010","journal-title":"Heart Rhythm"},{"key":"2022102512492176500_ehaa942-B5","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"ESC Scientific Document Group. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J"},{"key":"2022102512492176500_ehaa942-B6","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCULATIONAHA.118.039022","article-title":"Mapping and ablation of ventricular fibrillation associated with early repolarization syndrome","volume":"140","author":"Nademanee","year":"2019","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B7","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.jacc.2018.02.022","article-title":"Assessing the malignant ventricular arrhythmic substrate in patients with Brugada syndrome","volume":"71","author":"Pappone","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022102512492176500_ehaa942-B8","doi-asserted-by":"crossref","first-page":"e005053","DOI":"10.1161\/CIRCEP.117.005053","article-title":"Electrical substrate elimination in 135 consecutive patients with Brugada syndrome","volume":"10","author":"Pappone","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102512492176500_ehaa942-B9","first-page":"1900","article-title":"C. Non-invasive assessment of the arrhythmogenic substrate in Brugada syndrome using signal-averaged electrocardiogram: clinical implications from a prospective clinical trial","volume":"21","author":"Ciconte","year":"2019","journal-title":"Europace"},{"key":"2022102512492176500_ehaa942-B10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2022102512492176500_ehaa942-B11","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report","volume":"20","author":"Brugada","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"2022102512492176500_ehaa942-B12","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1093\/eurheartj\/ehz435","article-title":"Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores","volume":"40","author":"Tadros","year":"2019","journal-title":"Eur Heart J"},{"key":"2022102512492176500_ehaa942-B13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCULATIONAHA.118.035954","article-title":"Beyond the one gene-one disease paradigm: complex genetics and pleiotropy in inheritable cardiac disorders","volume":"140","author":"Cerrone","year":"2019","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cpcardiol.2015.06.002","article-title":"Brugada syndrome: clinical, genetic, molecular, cellular, and ionic aspects","volume":"41","author":"Antzelevitch","year":"2016","journal-title":"Curr Probl Cardiol"},{"key":"2022102512492176500_ehaa942-B15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/humu.23730","article-title":"Genetic interpretation and clinical translation of minor genes related to Brugada syndrome","volume":"40","author":"Campuzano","year":"2019","journal-title":"Hum Mutat"},{"key":"2022102512492176500_ehaa942-B16","first-page":"425","article-title":"Loss of function associated with novel mutations of the SCN5A gene in patients with Brugada syndrome","volume":"20","author":"Baroudi","year":"2004","journal-title":"Can J Cardiol"},{"key":"2022102512492176500_ehaa942-B17","first-page":"665","article-title":"Wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge","volume":"19","author":"Antzelevitch","year":"2017","journal-title":"Europace"},{"key":"2022102512492176500_ehaa942-B18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/cge.13552","article-title":"Brugada syndrome with SCN5A mutations exhibits more pronounced electrophysiological defects and more severe prognosis: a meta-analysis","volume":"97","author":"Chen","year":"2020","journal-title":"Clin Genet"},{"key":"2022102512492176500_ehaa942-B19","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/CIRCULATIONAHA.117.027983","article-title":"Genotype-phenotype correlation of SCN5A mutation for the clinical and electrocardiographic characteristics of probands with Brugada syndrome: a Japanese Multicenter Registry","volume":"135","author":"Yamagata","year":"2017","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B20","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0735-1097(02)01962-9","article-title":"Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients","volume":"40","author":"Smits","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2022102512492176500_ehaa942-B21","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/ng.2712","article-title":"Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death","volume":"45","author":"Bezzina","year":"2013","journal-title":"Nat Genet"},{"key":"2022102512492176500_ehaa942-B22","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/CIRCULATIONAHA.110.972612","article-title":"Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium","volume":"123","author":"Nademanee","year":"2011","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B23","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.jacc.2015.08.862","article-title":"Fibrosis, connexin-43, and conduction abnormalities in the Brugada syndrome","volume":"66","author":"Nademanee","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2022102512492176500_ehaa942-B24","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.jacc.2018.09.037","article-title":"Electroanatomic and pathologic right ventricular outflow tract abnormalities in patients with Brugada syndrome","volume":"72","author":"Pieroni","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022102512492176500_ehaa942-B25","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1161\/CIRCEP.115.003220","article-title":"Brugada syndrome phenotype elimination by epicardial substrate ablation","volume":"8","author":"Brugada","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102512492176500_ehaa942-B26","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1161\/01.CIR.0000068342.96569.A1","article-title":"Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation","volume":"107","author":"Saumarez","year":"2003","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B27","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/01.RES.83.8.824","article-title":"p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+\/H+ exchange and ERK1\/2","volume":"83","author":"Kusuhara","year":"1998","journal-title":"Circ Res"},{"key":"2022102512492176500_ehaa942-B28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.CIR.88.3.915","article-title":"Slow conduction in the infarcted human heart. \u2018Zigzag\u2019 course of activation","volume":"88","author":"de Bakker","year":"1993","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B29","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1161\/CIRCULATIONAHA.104.486977","article-title":"Three-dimensional electroanatomic voltage mapping increases accuracy of diagnosing arrhythmogenic right ventricular cardiomyopathy\/dysplasia","volume":"111","author":"Corrado","year":"2005","journal-title":"Circulation"},{"key":"2022102512492176500_ehaa942-B30","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.jacc.2014.01.067","article-title":"Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome","volume":"63","author":"Sz\u00e9l","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2022102512492176500_ehaa942-B31","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0735-1097(99)00590-2","article-title":"Combined assessment of T-wave alternans and late potentials used to predict arrhythmic events after myocardial infarction. A prospective study","volume":"35","author":"Ikeda","year":"2000","journal-title":"J Am Coll Cardiol"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/42\/11\/1082\/46621768\/ehaa942.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/42\/11\/1082\/46621768\/ehaa942.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T09:29:46Z","timestamp":1666690186000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/42\/11\/1082\/5998273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,21]]},"references-count":31,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,21]]},"published-print":{"date-parts":[[2021,3,14]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehaa942","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,14]]},"published":{"date-parts":[[2020,11,21]]}}}