{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:11:11Z","timestamp":1794431471054,"version":"4.9.1"},"reference-count":105,"publisher":"Oxford University Press (OUP)","issue":"27","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A substantial number of chronic coronary syndrome (CCS) patients undergoing percutaneous coronary intervention (PCI) experience periprocedural myocardial injury or infarction. Accurate diagnosis of these PCI-related complications is required to guide further management given that their occurrence may be associated with increased risk of major adverse cardiac events (MACE). Due to lack of scientific data, the cut-off thresholds of post-PCI cardiac troponin (cTn) elevation used for defining periprocedural myocardial injury and infarction, have been selected based on expert consensus opinions, and their prognostic relevance remains unclear. In this Consensus Document from the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI), we recommend, whenever possible, the measurement of baseline (pre-PCI) cTn and post-PCI cTn values in all CCS patients undergoing PCI. We confirm the prognostic relevance of the post-PCI cTn elevation &amp;gt;5\u00d7 99th percentile URL threshold used to define type 4a myocardial infarction (MI). In the absence of periprocedural angiographic flow-limiting complications or electrocardiogram (ECG) and imaging evidence of new myocardial ischaemia, we propose the same post-PCI cTn cut-off threshold (&amp;gt;5\u00d7 99th percentile URL) be used to define prognostically relevant \u2018major\u2019 periprocedural myocardial injury. As both type 4a MI and major periprocedural myocardial injury are strong independent predictors of all-cause mortality at 1 year post-PCI, they may be used as quality metrics and surrogate endpoints for clinical trials. Further research is needed to evaluate treatment strategies for reducing the risk of major periprocedural myocardial injury, type 4a MI, and MACE in CCS patients undergoing PCI.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehab271","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T16:38:32Z","timestamp":1619455112000},"page":"2630-2642","source":"Crossref","is-referenced-by-count":131,"title":["Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions: a Consensus Document of the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI)"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-1783","authenticated-orcid":false,"given":"Heerajnarain","family":"Bulluck","sequence":"first","affiliation":[{"name":"Department of Cardiology, Norfolk and Norwich University Hospital , Colney Lane, Norwich, Norfolk, NR4 7UY,","place":["UK"]},{"name":"Norwich Medical School, Bob Champion Research and Educational Building, Rosalind Franklin Road, University of East Anglia , Norwich Research Park. Norwich, Norfolk, NR4 7UQ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Paradies","sequence":"additional","affiliation":[{"name":"Cardiology Department, Maasstad Hospital , Maasstadweg 21, 3079 DZ Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-5178","authenticated-orcid":false,"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University , Via Pansini 5, 8013, Naples,","place":["Italy"]},{"name":"Cardiovascular Center Aalst OLV Hospital , Moorselbaan n. 164, 9300 Aalst,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7707-2254","authenticated-orcid":false,"given":"Andreas","family":"Baumbach","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, Barts Heart Centre , Charterhouse Square, London, EC1M 6BQ,","place":["UK"]},{"name":"Yale University School of Medicine , 333 Cedar St, New Haven, CT 06510,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico \u201cG. Rodolico-San Marco\u201d, University of Catania , Via Santa Sofia 78, 95100 Catania,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-574X","authenticated-orcid":false,"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cardiology Division, University of Pisa , Lungarno Antonio Pacinotti, 43, 56124 Pisa,","place":["Italy"]},{"name":"University of Pisa, and Cardiology Division, Pisa University Hospital AND Fondazione VillaSerena per la Ricerca , Citt\u00e0 Sant\u2019Angelo, Pescara,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Santa Maria della Misericordia Hospital , Piazzale Giorgio Menghini, 1, 06129 Perugia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-4980","authenticated-orcid":false,"given":"Sean M","family":"Davidson","sequence":"additional","affiliation":[{"name":"The Hatter Cardiovascular Institute, University College London , 67 Chenies Mews London, WC1E 6HX,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy N","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Weill Cornell Medical College, New York Presbyterian Hospital , 1414 York Ave, New York, NY 10021,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Ferdinandy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Semmelweis University ,\u00a0Nagyvarad t\u00e9r 4, Budapest, 1089","place":["Hungary"]},{"name":"Pharmahungary Group ,\u00a0Hajn\u00f3czy u. 6, Szeged, 6722","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0542-0448","authenticated-orcid":false,"given":"Sebastiano","family":"Gili","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Via Carlo Parea, 4, 20138 Milano MI ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-2107","authenticated-orcid":false,"given":"Mariann","family":"Gy\u00f6ngy\u00f6si","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Vienna , Waehringer Guertel 18-20, Vienna A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2975-6971","authenticated-orcid":false,"given":"Vijay","family":"Kunadian","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, M4:146 4th Floor William Leech Building, Newcastle University Medical School, Newcastle upon Tyne, NE2 4HH ,","place":["UK"]},{"name":"Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Cardiothoracic centre , High Heaton, Newcastle upon Tyne, NE7 7DN,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze-Yuan","family":"Ooi","sequence":"additional","affiliation":[{"name":"Eastern Heart Clinic, Prince of Wales Hospital , Barker St, Randwick NSW 2031,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-2777","authenticated-orcid":false,"given":"Rosalinda","family":"Madonna","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cardiology Division, University of Pisa , Lungarno Antonio Pacinotti, 43, 56124 Pisa,","place":["Italy"]},{"name":"Department of Internal Medicine, University of Texas Medical School , Houston, 77060 Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-7128","authenticated-orcid":false,"given":"Michael","family":"Marber","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London , Westminster Bridge Rd, London SE1 7EH,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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