{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:13:51Z","timestamp":1787242431468,"version":"build-2736575974"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K01HL133510-01A1"],"award-info":[{"award-number":["1K01HL133510-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL135866"],"award-info":[{"award-number":["R01 HL135866"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL14750"],"award-info":[{"award-number":["RO1 HL14750"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1-HL123271"],"award-info":[{"award-number":["DP1-HL123271"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL116280"],"award-info":[{"award-number":["R01HL116280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiomyopathy patients are prone to ventricular arrhythmias (VA) and sudden cardiac death. Current therapies to prevent VA include radiofrequency ablation to destroy slowly conducting pathways of viable myocardium which support re-entry. Here, we tested the reverse concept, namely that boosting local tissue viability in zones of slow conduction might eliminate slow conduction and suppress VA in ischaemic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Exosomes are extracellular vesicles laden with bioactive cargo. Exosomes secreted by cardiosphere-derived cells (CDCEXO) reduce scar and improve heart function after intramyocardial delivery. In a VA-prone porcine model of ischaemic cardiomyopathy, we injected CDCEXO or vehicle into zones of delayed conduction defined by electroanatomic mapping. Up to 1-month post-injection, CDCEXO, but not the vehicle, decreased myocardial scar, suppressed slowly conducting electrical pathways, and inhibited VA induction by programmed electrical stimulation. In silico reconstruction of electrical activity based on magnetic resonance images accurately reproduced the suppression of VA inducibility by CDCEXO. Strong anti-fibrotic effects of CDCEXO, evident histologically and by proteomic analysis from pig hearts, were confirmed in a co-culture assay of cardiomyocytes and fibroblasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biological substrate modification by exosome injection may be worth developing as a non-destructive alternative to conventional ablation for the prevention of recurrent ventricular tachyarrhythmias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehac042","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T07:12:24Z","timestamp":1643353944000},"page":"2139-2156","source":"Crossref","is-referenced-by-count":36,"title":["Biological substrate modification suppresses ventricular arrhythmias in a porcine model of chronic ischaemic cardiomyopathy"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-1488","authenticated-orcid":false,"given":"James F.","family":"Dawkins","sequence":"first","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-0026","authenticated-orcid":false,"given":"Ashkan","family":"Ehdaie","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-7433","authenticated-orcid":false,"given":"Russell","family":"Rogers","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Soetkamp","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackelyn","family":"Valle","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Holm","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbeth","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1546-8493","authenticated-orcid":false,"given":"Ileana","family":"Tremmel","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shehata","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunzhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-0322","authenticated-orcid":false,"given":"Adityo","family":"Prakosa","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation, Department of Biomedical Engineering, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8282-7399","authenticated-orcid":false,"given":"Joseph","family":"Yu","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation, Department of Biomedical Engineering, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E","family":"Van Eyk","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Trayanova","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation, Department of Biomedical Engineering, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3863-280X","authenticated-orcid":false,"given":"Eduardo","family":"Marb\u00e1n","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Cingolani","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"2022111105294334000_ehac042-B1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"2022111105294334000_ehac042-B2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1056\/NEJMoa071098","article-title":"Prognostic importance of defibrillator shocks in patients with heart failure","volume":"359","author":"Poole","year":"2008","journal-title":"N Engl J Med"},{"key":"2022111105294334000_ehac042-B3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/CIRCULATIONAHA.116.021955","article-title":"High-resolution mapping of postinfarction reentrant ventricular tachycardia electrophysiological characterization of the circuit","volume":"134","author":"Anter","year":"2016","journal-title":"Circulation"},{"key":"2022111105294334000_ehac042-B4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1513614","article-title":"Ventricular tachycardia ablation versus escalation of antiarrhythmic drugs","volume":"375","author":"Sapp","year":"2016","journal-title":"N Engl J Med"},{"key":"2022111105294334000_ehac042-B5","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.hrthm.2009.04.030","article-title":"EHRA\/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA)","volume":"6","author":"Aliot","year":"2009","journal-title":"Heart Rhythm"},{"key":"2022111105294334000_ehac042-B6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41551-018-0216-z","article-title":"A mechanistic roadmap for the clinical application of cardiac cell therapies","volume":"2","author":"Marban","year":"2018","journal-title":"Nat Biomed Eng"},{"key":"2022111105294334000_ehac042-B7","first-page":"201","article-title":"Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction","volume":"38","author":"Gallet","year":"2017","journal-title":"Eur Heart J"},{"key":"2022111105294334000_ehac042-B8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.CIR.73.4.645","article-title":"Endocardial catheter mapping in patients in sinus rhythm: relationship to underlying heart disease and ventricular arrhythmias","volume":"73","author":"Cassidy","year":"1986","journal-title":"Circulation"},{"key":"2022111105294334000_ehac042-B9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pbiomolbio.2014.08.009","article-title":"Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology","volume":"115","author":"Prakosa","year":"2014","journal-title":"Prog Biophys Mol Biol"},{"key":"2022111105294334000_ehac042-B10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fphys.2015.00282","article-title":"Accuracy of prediction of infarct-related arrhythmic circuits from image-based models reconstructed from low and high resolution MRI","volume":"6","author":"Deng","year":"2015","journal-title":"Front Physiol"},{"key":"2022111105294334000_ehac042-B11","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s10439-012-0593-5","article-title":"A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models","volume":"40","author":"Bayer","year":"2012","journal-title":"Ann Biomed Eng"},{"key":"2022111105294334000_ehac042-B12","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1038\/ncomms11437","article-title":"Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models","volume":"7","author":"Arevalo","year":"2016","journal-title":"Nat Commun"},{"key":"2022111105294334000_ehac042-B13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.RES.0000174429.00987.17","article-title":"Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks","volume":"97","author":"Rodriguez","year":"2005","journal-title":"Circ Res"},{"key":"2022111105294334000_ehac042-B14","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1161\/CIRCULATIONAHA.118.034365","article-title":"Proteomic architecture of human coronary and aortic atherosclerosis","volume":"137","author":"Herrington","year":"2018","journal-title":"Circulation"},{"key":"2022111105294334000_ehac042-B15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-61779-523-7_20","article-title":"Isolation of cardiac myocytes and fibroblasts from neonatal rat pups","volume":"843","author":"Golden","year":"2012","journal-title":"Methods Mol Biol"},{"key":"2022111105294334000_ehac042-B16","doi-asserted-by":"crossref","first-page":"1456888","DOI":"10.1080\/20013078.2018.1456888","article-title":"Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes","volume":"7","author":"Middleton","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"2022111105294334000_ehac042-B17","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1161\/ATVBAHA.119.313115","article-title":"Mechanism of enhanced MerTK-dependent macrophage efferocytosis by extracellular vesicles","volume":"39","author":"de Couto","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022111105294334000_ehac042-B18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nbt.2465","article-title":"Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18","volume":"31","author":"Kapoor","year":"2013","journal-title":"Nat Biotechnol"},{"key":"2022111105294334000_ehac042-B19","doi-asserted-by":"crossref","first-page":"119741","DOI":"10.1016\/j.biomaterials.2019.119741","article-title":"Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing","volume":"233","author":"Mastikhina","year":"2020","journal-title":"Biomaterials"},{"key":"2022111105294334000_ehac042-B20","doi-asserted-by":"crossref","first-page":"e113805","DOI":"10.1371\/journal.pone.0113805","article-title":"Allogeneic cardiospheres delivered via percutaneous transendocardial injection increase viable myocardium, decrease scar size, and attenuate cardiac dilatation in porcine ischemic cardiomyopathy","volume":"9","author":"Yee","year":"2014","journal-title":"PLoS One"},{"key":"2022111105294334000_ehac042-B21","doi-asserted-by":"crossref","first-page":"e004743","DOI":"10.1161\/CIRCEP.117.004743","article-title":"Imaging-based simulations for predicting sudden death and guiding ventricular tachycardia ablation","volume":"10","author":"Trayanova","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022111105294334000_ehac042-B22","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1161\/CIRCULATIONAHA.106.653568","article-title":"Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction","volume":"115","author":"Schmidt","year":"2007","journal-title":"Circulation"},{"key":"2022111105294334000_ehac042-B23","doi-asserted-by":"crossref","first-page":"eabb3336","DOI":"10.1126\/scitranslmed.abb3336","article-title":"Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy","volume":"12","author":"Hirai","year":"2020","journal-title":"Sci Transl Med"},{"key":"2022111105294334000_ehac042-B24","first-page":"87","article-title":"Subfractionation of heart tissue: the \u2018in sequence\u2019 myofilament protein extraction of myocardial tissue","volume":"357","author":"Kane","year":"2007","journal-title":"Methods Mol Biol"},{"key":"2022111105294334000_ehac042-B25","doi-asserted-by":"crossref","first-page":"H219","DOI":"10.1152\/ajpheart.00041.2016","article-title":"Discordant signaling and autophagy response to fasting in hearts of obese mice: implications for ischemia tolerance","volume":"311","author":"Andres","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022111105294334000_ehac042-B26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","article-title":"NF-kappaB at the crossroads of life and death","volume":"3","author":"Karin","year":"2002","journal-title":"Nat Immunol"},{"key":"2022111105294334000_ehac042-B27","doi-asserted-by":"crossref","first-page":"22798","DOI":"10.1074\/jbc.M114.568535","article-title":"Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner","volume":"289","author":"Lee","year":"2014","journal-title":"J Biol Chem"},{"key":"2022111105294334000_ehac042-B28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijcard.2017.05.018","article-title":"Desmoplakin missense and non-missense mutations in arrhythmogenic right ventricular cardiomyopathy: genotype-phenotype correlation","volume":"249","author":"Castelletti","year":"2017","journal-title":"Int J Cardiol"},{"key":"2022111105294334000_ehac042-B29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10840-009-9421-8","article-title":"Relationship of late potentials to the ventricular tachycardia circuit defined by entrainment","volume":"26","author":"Hsia","year":"2009","journal-title":"J Interv Card Electrophysiol"},{"key":"2022111105294334000_ehac042-B30","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.ajpath.2013.06.016","article-title":"Early growth response 3 (Egr-3) is induced by transforming growth factor-beta and regulates fibrogenic responses","volume":"183","author":"Fang","year":"2013","journal-title":"Am J Pathol"},{"key":"2022111105294334000_ehac042-B31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/jcmm.15814","article-title":"Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3)","volume":"25","author":"Teng","year":"2021","journal-title":"J Cell Mol Med"},{"key":"2022111105294334000_ehac042-B32","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/CIRCRESAHA.112.300682","article-title":"MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress","volume":"112","author":"Huang","year":"2013","journal-title":"Circ Res"},{"key":"2022111105294334000_ehac042-B33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.stemcr.2014.04.006","article-title":"Exosomes as critical agents of cardiac regeneration triggered by cell therapy","volume":"2","author":"Ibrahim","year":"2014","journal-title":"Stem Cell Reports"},{"key":"2022111105294334000_ehac042-B34","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvu167","article-title":"Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction","volume":"103","author":"Barile","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2022111105294334000_ehac042-B35","doi-asserted-by":"crossref","first-page":"12775","DOI":"10.1038\/srep12775","article-title":"MiR-210 inhibits NF-kappaB signaling pathway by targeting DR6 in osteoarthritis","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci Rep"},{"key":"2022111105294334000_ehac042-B36","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/ATVBAHA.117.310597","article-title":"MiR-146a regulates neutrophil extracellular trap formation that predicts adverse cardiovascular events in patients with atrial fibrillation","volume":"38","author":"Arroyo","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022111105294334000_ehac042-B37","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.hrthm.2015.09.023","article-title":"Substrate mapping for unstable ventricular tachycardia","volume":"13","author":"Santangeli","year":"2016","journal-title":"Heart Rhythm"},{"key":"2022111105294334000_ehac042-B38","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/jce.13088","article-title":"Substrate-based ablation versus ablation guided by activation and entrainment mapping for ventricular tachycardia: a systematic review and meta-analysis","volume":"27","author":"Kumar","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2022111105294334000_ehac042-B39","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jacc.2005.12.062","article-title":"Isolated potentials during sinus rhythm and pace-mapping within scars as guides for ablation of post-infarction ventricular tachycardia","volume":"47","author":"Bogun","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2022111105294334000_ehac042-B40","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1056\/NEJMoa065457","article-title":"Prophylactic catheter ablation for the prevention of defibrillator therapy","volume":"357","author":"Reddy","year":"2007","journal-title":"N Engl J Med"},{"key":"2022111105294334000_ehac042-B41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.105.540062","article-title":"Comparison of electrode cooling between internal and open irrigation in radiofrequency ablation lesion depth and incidence of thrombus and steam pop","volume":"113","author":"Yokoyama","year":"2006","journal-title":"Circulation"},{"key":"2022111105294334000_ehac042-B42","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1093\/europace\/euaa169","article-title":"Arrhythmia exacerbation after post-infarction ventricular tachycardia ablation: prevalence and prognostic significance","volume":"22","author":"Siontis","year":"2020","journal-title":"Europace"},{"key":"2022111105294334000_ehac042-B43","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jacc.2012.02.070","article-title":"Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation","volume":"60","author":"Klem","year":"2012","journal-title":"J Am Coll Cardiol"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/43\/22\/2139\/46952720\/ehac042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/43\/22\/2139\/46952720\/ehac042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:30:17Z","timestamp":1668126617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/43\/22\/2139\/6545456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":43,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,3,9]]},"published-print":{"date-parts":[[2022,6,6]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehac042","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,7]]},"published":{"date-parts":[[2022,3,9]]}}}