{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:55:02Z","timestamp":1793764502440,"version":"4.6.1"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NIH"},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["1R01HL139874-01"],"award-info":[{"award-number":["1R01HL139874-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Veteran Affairs Merit","award":["BX004861-01"],"award-info":[{"award-number":["BX004861-01"]}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stockholm County Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Electrical disturbances, such as atrial fibrillation (AF), dyssynchrony, tachycardia, and premature ventricular contractions (PVCs), are present in most patients with heart failure (HF). While these disturbances may be the consequence of HF, increasing evidence suggests that they may also cause or aggravate HF. Animal studies show that longer-lasting left bundle branch block, tachycardia, AF, and PVCs lead to functional derangements at the organ, cellular, and molecular level. Conversely, electrical treatment may reverse or mitigate HF. Clinical studies have shown the superiority of atrial and pulmonary vein ablation for rhythm control and AV nodal ablation for rate control in AF patients when compared with medical treatment. Ablation of PVCs can also improve left ventricular function. Cardiac resynchronization therapy (CRT) is an established adjunct therapy currently undergoing several interesting innovations. The current guideline recommendations reflect the safety and efficacy of these ablation therapies and CRT, but currently, these therapies are heavily underutilized. This review focuses on the electrical treatment of HF with reduced ejection fraction (HFrEF). We believe that the team of specialists treating an HF patient should incorporate an electrophysiologist in order to achieve a more widespread use of electrical therapies in the management of HFrEF and should also include individual conditions of the patient, such as body size and gender in therapy fine-tuning.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehac088","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T15:14:14Z","timestamp":1644419654000},"page":"1917-1927","source":"Crossref","is-referenced-by-count":42,"title":["Electrical management of heart failure: from pathophysiology to treatment"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-9032","authenticated-orcid":false,"given":"Frits W","family":"Prinzen","sequence":"first","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University , PO Box 616, 6200 MD Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Istituto Cardiocentro Ticino , Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Mullens","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost Limburg , Genk, Belgium"},{"name":"Biomedical Research Institute, Faculty of Medicine and Life Sciences, University Hasselt, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-6023","authenticated-orcid":false,"given":"Cecilia","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet , Solna, Sweden"},{"name":"Department of Cardiology, Karolinska University Hospital , Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose F","family":"Huizar","sequence":"additional","affiliation":[{"name":"Cardiology Division, Virginia Commonwealth University\/Pauley Heart Center , Richmond, VA, USA"},{"name":"Cardiology Division, Hunter Holmes McGuire Veterans Affairs Medical Center , Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"2022102518223435600_ehac088-B1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ejhf.1142","article-title":"CRT Survey II: an ESC survey of cardiac resynchronization therapy in 11088 patients\u2014who is doing what to whom and how?","volume":"20","author":"Dickstein","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2022102518223435600_ehac088-B2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ejhf.162","article-title":"Age, prognostic impact of QRS prolongation and left bundle branch block, and utilization of cardiac resynchronization therapy: findings from 14 713 patients in the Swedish Heart Failure Registry","volume":"16","author":"Lund","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"2022102518223435600_ehac088-B3","doi-asserted-by":"crossref","first-page":"2D","DOI":"10.1016\/S0002-9149(02)03373-8","article-title":"Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy","volume":"91","author":"Maisel","year":"2003","journal-title":"Am J Cardiol"},{"key":"2022102518223435600_ehac088-B4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pcad.2021.04.001","article-title":"Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy","volume":"66","author":"Huizar","year":"2021","journal-title":"Prog Cardiovasc Dis"},{"key":"2022102518223435600_ehac088-B5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/eurheartj\/ehi008","article-title":"Left bundle branch block induces ventricular remodelling and functional septal hypoperfusion","volume":"26","author":"Vernooy","year":"2005","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0167-5273(96)02728-3","article-title":"Tachycardia induced cardiomyopathy in dogs; relation between chronic supraventricular and chronic ventricular tachycardia","volume":"56","author":"Zupan","year":"1996","journal-title":"Int J Cardiol"},{"key":"2022102518223435600_ehac088-B7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/CIRCEP.111.962381","article-title":"Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy","volume":"4","author":"Huizar","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B8","doi-asserted-by":"crossref","first-page":"H725","DOI":"10.1152\/ajpheart.00440.2013","article-title":"Chronic atrial fibrillation causes left ventricular dysfunction in dogs but not goats: experience with dogs, goats, and pigs","volume":"305","author":"Dosdall","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022102518223435600_ehac088-B9","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/ejhf.1531","article-title":"Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of the Heart Failure Association of the European Society of Cardiology","volume":"21","author":"Seferovic","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2022102518223435600_ehac088-B10","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/CIRCULATIONAHA.108.794834","article-title":"Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy","volume":"119","author":"Aiba","year":"2009","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.hrthm.2015.10.037","article-title":"JPH-2 interacts with Cai-handling proteins and ion channels in dyads: contribution to premature ventricular contraction-induced cardiomyopathy","volume":"13","author":"Jiang","year":"2016","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B12","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.hrthm.2014.07.022","article-title":"Cellular mechanism of premature ventricular contraction-induced cardiomyopathy","volume":"11","author":"Wang","year":"2014","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.hroo.2020.12.021","article-title":"Eccentric hypertrophy in an animal model of mid- and long-term premature ventricular contraction-induced cardiomyopathy","volume":"2","author":"Torrado","year":"2021","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ijcard.2013.12.180","article-title":"Tachycardia mediated cardiomyopathy: pathophysiology, mechanisms, clinical features and management","volume":"172","author":"Gupta","year":"2014","journal-title":"Int J Cardiol"},{"key":"2022102518223435600_ehac088-B15","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1016\/j.jacc.2017.02.049","article-title":"Histopathological and immunological characteristics of tachycardia-induced cardiomyopathy","volume":"69","author":"Mueller","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B16","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1161\/01.CIR.88.6.2962","article-title":"Postextrasystolic potentiation. Do we really know what it means and how to use it?","volume":"88","author":"Cooper","year":"1993","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B17","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.jacc.2019.02.045","article-title":"Arrhythmia-induced cardiomyopathy: JACC state-of-the-art review","volume":"73","author":"Huizar","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1253\/jcj.34.419","article-title":"Experimental studies on myocardial contractility and hemodynamics in extrasystoles","volume":"34","author":"Takada","year":"1970","journal-title":"Jpn Circ J"},{"key":"2022102518223435600_ehac088-B19","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1161\/01.CIR.66.4.771","article-title":"Postextrasystolic potentiation and echocardiography: the effect of varying basic heart rate, extrasystolic coupling interval and postextrasystolic interval","volume":"66","author":"Cooper","year":"1982","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B20","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1161\/CIRCHEARTFAILURE.112.968321","article-title":"Irregular rhythm adversely influences calcium handling in ventricular myocardium. Implications for the interaction between heart failure and atrial fibrillation","volume":"5","author":"Ling","year":"2012","journal-title":"Circ Heart Fail"},{"key":"2022102518223435600_ehac088-B21","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1161\/01.CIR.96.8.2641","article-title":"Predictive value of cardiac troponin T in pediatic patients at risk for myocardial injury","volume":"96","author":"Lipshultz","year":"1997","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B22","doi-asserted-by":"crossref","first-page":"i21","DOI":"10.1093\/europace\/euaa387","article-title":"Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation","volume":"23","author":"Lyon","year":"2021","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B23","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/europace\/euab143","article-title":"Understanding the effects of heartbeat irregularity on ventricular function in human atrial fibrillation: simulation models may help to untie the knot","volume":"23","author":"Mase","year":"2021","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/CIRCRESAHA.113.300270","article-title":"Electromechanical dyssynchrony and resynchronization of the failing heart","volume":"113","author":"Kirk","year":"2013","journal-title":"Circ Res"},{"key":"2022102518223435600_ehac088-B25","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/01.CIR.0000088782.99568.CA","article-title":"Regional alterations in protein expression in the dyssynchronous failing heart","volume":"108","author":"Spragg","year":"2003","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B26","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/europace\/euy035","article-title":"Pathobiology of cardiac dyssynchrony and resynchronization therapy","volume":"20","author":"Nguy\u00ean","year":"2018","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0008-6363(99)00032-2","article-title":"Pacing-induced heart failure: a model to study the mechanism of disease progression and novel therapy in heart failure","volume":"42","author":"Moe","year":"1999","journal-title":"Cardiovasc Res"},{"key":"2022102518223435600_ehac088-B28","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/eurjhf\/hfs095","article-title":"Prediction and mechanism of frequent ventricular premature contractions related to haemodynamic deterioration","volume":"14","author":"Kuroki","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2022102518223435600_ehac088-B29","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0735-1097(91)90811-M","article-title":"Diastolic mitral regurgitation with atrioventricular conduction abnormalities: relation of mitral flow velocity to transmitral pressure gradients in conscious dogs","volume":"18","author":"Appleton","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B30","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0735-1097(02)01727-8","article-title":"Cardiac resynchronization therapy restores optimal atrioventricular mechanical timing in heart failure patients with ventricular conduction delay","volume":"39","author":"Auricchio","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B31","first-page":"euab248","article-title":"Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study","author":"Salden","year":"2022","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1536\/ihj.49.39","article-title":"Clinical characteristics, treatment, and outcome of tachycardia induced cardiomyopathy","volume":"49","author":"Watanabe","year":"2008","journal-title":"Int Heart J"},{"key":"2022102518223435600_ehac088-B33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10840-012-9727-9","article-title":"Reversal of cardiomyopathy in patients with congestive heart failure secondary to tachycardia","volume":"36","author":"Donghua","year":"2013","journal-title":"J Interv Card Electrophysiol"},{"key":"2022102518223435600_ehac088-B34","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.jacc.2009.02.014","article-title":"Tachycardia-mediated cardiomyopathy secondary to focal atrial tachycardia: long-term outcome after catheter ablation","volume":"53","author":"Medi","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B35","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.hrthm.2014.04.023","article-title":"Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy","volume":"11","author":"Moore","year":"2014","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1540-8167.2006.00653.x","article-title":"Reversal of left ventricular dysfunction following ablation of atrial fibrillation","volume":"18","author":"Gentlesk","year":"2007","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2022102518223435600_ehac088-B37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC). Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B38","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/CIRCEP.113.000681","article-title":"Diffuse ventricular fibrosis is a late outcome of tachycardia-mediated cardiomyopathy after successful ablation","volume":"6","author":"Ling","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.amjcard.2011.08.009","article-title":"Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk In Communities [ARIC] Study)","volume":"109","author":"Agarwal","year":"2012","journal-title":"Am J Cardiol"},{"key":"2022102518223435600_ehac088-B40","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jacep.2020.08.028","article-title":"Outcomes of premature ventricular contraction-cardiomyopathy in the veteran population: a secondary analysis of the CHF-STAT study","volume":"7","author":"Huizar","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jacep.2015.04.005","article-title":"Multicenter outcomes for catheter ablation of idiopathic premature ventricular complexes","volume":"1","author":"Latchamsetty","year":"2015","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B42","doi-asserted-by":"crossref","first-page":"e12702","DOI":"10.1111\/anec.12702","article-title":"The effect of idiopathic premature ventricular complexes on left ventricular ejection fraction","volume":"25","author":"Altintas","year":"2020","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2022102518223435600_ehac088-B43","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.hrthm.2015.11.016","article-title":"Impact of ventricular ectopic burden in a premature ventricular contraction-induced cardiomyopathy animal model","volume":"13","author":"Tan","year":"2016","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B44","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/jce.12967","article-title":"A new combined parameter to predict premature ventricular complexes induced cardiomyopathy: impact and recognition of epicardial origin","volume":"27","author":"Hamon","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2022102518223435600_ehac088-B45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jacc.2015.04.062","article-title":"Ventricular ectopy as a predictor of heart failure and death","volume":"66","author":"Dukes","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B46","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/pace.12852","article-title":"Longer ambulatory ECG monitoring increases identification of clinically significant ectopy","volume":"39","author":"Loring","year":"2016","journal-title":"Pacing Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.hrthm.2013.10.033","article-title":"Relative efficacy of catheter ablation vs antiarrhythmic drugs in treating premature ventricular contractions: a single-center retrospective study","volume":"11","author":"Zhong","year":"2014","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B48","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCEP.113.000805","article-title":"Radiofrequency ablation versus antiarrhythmic medication for treatment of ventricular premature beats from the right ventricular outflow tract: prospective randomized study","volume":"7","author":"Ling","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B49","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jacep.2015.07.012","article-title":"Cryoablation for ventricular arrhythmias arising from the papillary muscles of the left ventricle guided by intracardiac echocardiography and image integration","volume":"1","author":"Rivera","year":"2015","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B50","doi-asserted-by":"crossref","first-page":"e003874","DOI":"10.1161\/CIRCEP.115.003874","article-title":"Results of cryoenergy and radiofrequency-based catheter ablation for treating ventricular arrhythmias arising from the papillary muscles of the left ventricle, guided by intracardiac echocardiography and image integration","volume":"9","author":"Rivera","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B51","first-page":"378","article-title":"Influence of myocardial scar on the response to frequent premature ventricular complex ablation","volume":"105","author":"Penela","year":"2019","journal-title":"Heart"},{"key":"2022102518223435600_ehac088-B52","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0140-6736(94)91895-3","article-title":"Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA)","volume":"344","author":"Doval","year":"1994","journal-title":"Lancet"},{"key":"2022102518223435600_ehac088-B53","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0140-6736(16)31258-2","article-title":"Rate control in atrial fibrillation","volume":"388","author":"Van Gelder","year":"2016","journal-title":"Lancet"},{"key":"2022102518223435600_ehac088-B54","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.jacc.2011.06.055","article-title":"The effect of rate control on quality of life in patients with permanent atrial fibrillation: data from the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) study","volume":"58","author":"Groenveld","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B55","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJMoa1001337","article-title":"Lenient versus strict rate control in patients with atrial fibrillation","volume":"362","author":"Van Gelder","year":"2010","journal-title":"N Engl J Med"},{"key":"2022102518223435600_ehac088-B56","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B57","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.ahj.2004.11.030","article-title":"Rate control versus rhythm control for patients with persistent atrial fibrillation with mild to moderate heart failure: results from the RAte Control versus Electrical cardioversion (RACE) study","volume":"149","author":"Hagens","year":"2005","journal-title":"Am Heart J"},{"key":"2022102518223435600_ehac088-B58","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1056\/NEJMoa021328","article-title":"A Comparison of rate control and rhythm control in patients with atrial fibrillation","volume":"347","author":"Wyse","year":"2002","journal-title":"N Engl J Med"},{"key":"2022102518223435600_ehac088-B59","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1056\/NEJMoa0708789","article-title":"Rhythm control versus rate control for atrial fibrillation and heart failure","volume":"358","author":"Roy","year":"2008","journal-title":"N Engl J Med"},{"key":"2022102518223435600_ehac088-B60","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/hrt.2008.158931","article-title":"A randomised, controlled study of rate versus rhythm control in patients with chronic atrial fibrillation and heart failure: (CAFE-II Study)","volume":"95","author":"Shelton","year":"2009","journal-title":"Heart"},{"key":"2022102518223435600_ehac088-B61","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/01.CIR.0000121736.16643.11","article-title":"Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study","volume":"109","author":"Corley","year":"2004","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B62","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1161\/CIRCEP.113.000806","article-title":"A randomized controlled trial of catheter ablation versus medical treatment of atrial fibrillation in heart failure (the CAMTAF trial)","volume":"7","author":"Hunter","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B63","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/hrt.2010.207340","article-title":"Radiofrequency ablation for persistent atrial fibrillation in patients with advanced heart failure and severe left ventricular systolic dysfunction: a randomised controlled trial","volume":"97","author":"MacDonald","year":"2011","journal-title":"Heart"},{"key":"2022102518223435600_ehac088-B64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMoa1707855","article-title":"Catheter ablation for atrial fibrillation with heart failure","volume":"378","author":"Marrouche","year":"2018","journal-title":"N Engl J Med"},{"key":"2022102518223435600_ehac088-B65","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.jacep.2020.08.019","article-title":"Catheter ablation versus medication in atrial fibrillation and systolic dysfunction: late outcomes of CAMERA-MRI Study","volume":"6","author":"Sugumar","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B66","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.amjcard.2005.11.044","article-title":"Ventricular remodeling during long-term right ventricular pacing following His bundle ablation","volume":"97","author":"Vernooy","year":"2006","journal-title":"Am J Cardiol"},{"key":"2022102518223435600_ehac088-B67","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1093\/eurheartj\/ehy555","article-title":"A randomized controlled trial of atrioventricular junction ablation and cardiac resynchronization therapy in patients with permanent atrial fibrillation and narrow QRS","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B68","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1093\/eurheartj\/ehab569","article-title":"AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial","volume":"42","author":"Brignole","year":"2021","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B69","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jchf.2013.06.003","article-title":"Cardiac resynchronization therapy in patients with atrial fibrillation: the CERTIFY study (Cardiac Resynchronization Therapy in Atrial Fibrillation Patients Multinational Registry)","volume":"1","author":"Gasparini","year":"2013","journal-title":"JACC Heart Fail"},{"key":"2022102518223435600_ehac088-B70","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCULATIONAHA.112.101055","article-title":"Left bundle-branch block induced by transcatheter aortic valve implantation increases risk of death","volume":"126","author":"Houthuizen","year":"2012","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B71","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B72","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jacep.2020.11.010","article-title":"Redefining the classifications of response to cardiac resynchronization therapy: results from the REVERSE Study","volume":"7","author":"Gold","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B73","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/europace\/euu205","article-title":"Gender and utilization of cardiac resynchronization therapy, and prognostic impact of QRS prolongation and left bundle branch block in heart failure","volume":"17","author":"Linde","year":"2015","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B74","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijcard.2018.07.060","article-title":"The definition of left bundle branch block influences the response to cardiac resynchronization therapy","volume":"269","author":"Caputo","year":"2018","journal-title":"Int J Cardiol"},{"key":"2022102518223435600_ehac088-B75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacep.2019.10.009","article-title":"Evaluating electrocardiography-based identification of cardiac resynchronization therapy responders beyond current left bundle branch block definitions","volume":"6","author":"van Stipdonk","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B76","doi-asserted-by":"crossref","first-page":"e006497","DOI":"10.1161\/CIRCEP.118.006497","article-title":"QRS area is a strong determinant of outcome in cardiac resynchronization therapy","volume":"11","author":"van Stipdonk","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B77","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.jacc.2017.02.059","article-title":"Cardiac resynchronization therapy with wireless left ventricular endocardial pacing: the SELECT-LV Study","volume":"69","author":"Reddy","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B78","doi-asserted-by":"crossref","first-page":"e006934","DOI":"10.1161\/CIRCEP.118.006934","article-title":"His-optimized cardiac resynchronization therapy to maximize electrical resynchronization: a feasibility study","volume":"12","author":"Vijayaraman","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B79","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.hrthm.2021.07.057","article-title":"Left bundle branch-optimized cardiac resynchronization therapy (LOT-CRT): results from an international LBBAP collaborative study group","volume":"19","author":"Jastrz\u0119bski","year":"2022","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B80","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.hrthm.2018.08.028","article-title":"Vectorcardiographic QRS area is associated with long-term outcome after cardiac resynchronization therapy","volume":"16","author":"Emerek","year":"2019","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B81","doi-asserted-by":"crossref","first-page":"e013539","DOI":"10.1161\/JAHA.119.013539","article-title":"Changes in QRS area and QRS duration after cardiac resynchronization therapy predict cardiac mortality, heart failure hospitalizations, and ventricular arrhythmias","volume":"8","author":"Okafor","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2022102518223435600_ehac088-B82","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.hrthm.2015.07.033","article-title":"Vectorcardiographic QRS area identifies delayed left ventricular lateral wall activation determined by electroanatomic mapping in candidates for cardiac resynchronization therapy","volume":"13","author":"Rad","year":"2016","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B83","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jelectrocard.2014.10.003","article-title":"Vectorcardiographic QRS area as a novel predictor of response to cardiac resynchronization therapy","volume":"48","author":"van Deursen","year":"2015","journal-title":"J Electrocardiol"},{"key":"2022102518223435600_ehac088-B84","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jelectrocard.2018.01.009","article-title":"Relationship between vectorcardiographic QRS area, myocardial scar quantification, and response to cardiac resynchronization therapy","volume":"51","author":"Nguy\u00ean","year":"2018","journal-title":"J Electrocardiol"},{"key":"2022102518223435600_ehac088-B85","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1056\/NEJMoa0706695","article-title":"Cardiac-resynchronization therapy in heart failure with narrow QRS complexes","volume":"357","author":"Beshai","year":"2007","journal-title":"N Engl J Med"},{"key":"2022102518223435600_ehac088-B86","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1306687","article-title":"Cardiac-resynchronization therapy in heart failure with a narrow QRS complex","volume":"369","author":"Ruschitzka","year":"2013","journal-title":"N Engl J Med"},{"key":"2022102518223435600_ehac088-B87","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/ehjci\/jey029","article-title":"Assessment of mechanical dyssynchrony can improve the prognostic value of guideline-based patient selection for cardiac resynchronization therapy","volume":"20","author":"Beela","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022102518223435600_ehac088-B88","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1093\/eurheartj\/ehaa603","article-title":"Imaging predictors of response to cardiac resynchronization therapy: left ventricular work asymmetry by echocardiography and septal viability by cardiac magnetic resonance","volume":"41","author":"Aalen","year":"2020","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B89","doi-asserted-by":"crossref","first-page":"e003744","DOI":"10.1161\/CIRCIMAGING.115.003744","article-title":"Differentiating electromechanical from non\u2013electrical substrates of mechanical discoordination to identify responders to cardiac resynchronization","volume":"8","author":"Lumens","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022102518223435600_ehac088-B90","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jacep.2017.01.018","article-title":"Real-time X-MRI-guided left ventricular lead implantation for targeted delivery of cardiac resynchronization therapy","volume":"3","author":"Behar","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B91","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/europace\/euz184","article-title":"Electrically vs. imaging-guided left ventricular lead placement in cardiac resynchronization therapy: a randomized controlled trial","volume":"21","author":"Stephansen","year":"2019","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B92","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.amjcard.2021.10.027","article-title":"Usefulness of multisite ventricular pacing in nonresponders to cardiac resynchronization therapy","volume":"164","author":"Saba","year":"2022","journal-title":"Am J Cardiol"},{"key":"2022102518223435600_ehac088-B93","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1093\/eurheartj\/ehv723","article-title":"ALternate Site Cardiac ResYNChronization (ALSYNC): a prospective and multicentre study of left ventricular endocardial pacing for cardiac resynchronization therapy","volume":"37","author":"Morgan","year":"2016","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B94","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/europace\/eut435","article-title":"Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study","volume":"16","author":"Auricchio","year":"2014","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B95","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ahj.2019.04.002","article-title":"Design and rationale for the Stimulation Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in non-responders and previously untreatable patients (SOLVE-CRT) trial","volume":"217","author":"Singh","year":"2019","journal-title":"Am Heart J"},{"key":"2022102518223435600_ehac088-B96","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIRCEP.111.965814","article-title":"Endocardial left ventricular pacing improves cardiac resynchronization therapy in chronic asynchronous infarction and heart failure models","volume":"5","author":"Strik","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B97","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.56.6.996","article-title":"Longitudinal dissociation in the His bundle. Bundle branch block due to asynchronous conduction within the His bundle in man","volume":"56","author":"Narula","year":"1977","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B98","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/CIRCEP.109.882910","article-title":"Left ventricular septal and left ventricular apical pacing chronically maintain cardiac contractile coordination, pump function and efficiency","volume":"2","author":"Mills","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022102518223435600_ehac088-B99","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jacc.2019.11.040","article-title":"Short-term hemodynamic and electrophysiological effects of cardiac resynchronization by left ventricular septal pacing","volume":"75","author":"Salden","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B100","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.hrthm.2019.05.009","article-title":"On-treatment comparison between corrective His bundle pacing and biventricular pacing for cardiac resynchronization: a secondary analysis of the His-SYNC pilot trial","volume":"16","author":"Upadhyay","year":"2019","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B101","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/j.jacc.2018.09.073","article-title":"His resynchronization versus biventricular pacing in patients with heart failure and left bundle branch block","volume":"72","author":"Arnold","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B102","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jacep.2020.04.011","article-title":"Cardiac resynchronization therapy in patients with nonischemic cardiomyopathy using left bundle branch pacing","volume":"6","author":"Huang","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B103","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/CIRCULATIONAHA.118.038648","article-title":"Intracardiac delineation of septal conduction in left bundle-branch block patterns","volume":"139","author":"Upadhyay","year":"2019","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B104","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jacep.2016.01.010","article-title":"A possible role for pacing the left ventricular septum in cardiac resynchronization therapy","volume":"2","author":"Rademakers","year":"2016","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B105","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.hrthm.2020.12.031","article-title":"Intermediate-term performance and safety of His-bundle pacing leads: a single-center experience","volume":"18","author":"Teigeler","year":"2021","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B106","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1161\/CIRCULATIONAHA.110.992552","article-title":"Primary results from the SmartDelay determined AV optimization: a comparison to other AV delay methods used in cardiac resynchronization therapy (SMART-AV) trial: a randomized trial comparing empirical, echocardiography-guided, and algorithmic atrioventricular delay programming in cardiac resynchronization therapy","volume":"122","author":"Ellenbogen","year":"2010","journal-title":"Circulation"},{"key":"2022102518223435600_ehac088-B107","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.hrthm.2017.08.017","article-title":"Continuous optimization of cardiac resynchronization therapy reduces atrial fibrillation in heart failure patients: results of the adaptive cardiac resynchronization therapy trial","volume":"14","author":"Birnie","year":"2017","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B108","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.hrthm.2019.01.020","article-title":"Dynamic programming of atrioventricular delay improves electrical synchrony in a multicenter cardiac resynchronization therapy study","volume":"16","author":"Thibault","year":"2019","journal-title":"Heart Rhythm"},{"key":"2022102518223435600_ehac088-B109","first-page":"730","article-title":"Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial","volume":"38","author":"Brugada","year":"2017","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B110","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrcardio.2013.114","article-title":"Cardiac contractility modulation therapy in advanced systolic heart failure","volume":"10","author":"Lyon","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"2022102518223435600_ehac088-B111","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jchf.2018.04.010","article-title":"A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation","volume":"6","author":"Abraham","year":"2018","journal-title":"JACC Heart Fail"},{"key":"2022102518223435600_ehac088-B112","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jchf.2015.10.006","article-title":"Determining the feasibility of spinal cord neuromodulation for the treatment of chronic systolic heart failure: the DEFEAT-HF study","volume":"4","author":"Zipes","year":"2016","journal-title":"JACC Heart Fail"},{"key":"2022102518223435600_ehac088-B113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2020.05.015","article-title":"Baroreflex activation therapy in patients with heart failure with reduced ejection fraction","volume":"76","author":"Zile","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B114","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/eurheartj\/ehz467","article-title":"2019 ESC Guidelines for the management of patients with supraventricular tachycardia: the Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)","volume":"41","author":"Brugada","year":"2020","journal-title":"Eur Heart J"},{"key":"2022102518223435600_ehac088-B115","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/europace\/euz132","article-title":"2019 HRS\/EHRA\/APHRS\/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias","volume":"21","author":"Cronin","year":"2019","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B116","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1093\/europace\/euu300","article-title":"Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 report from the European Heart Rhythm Association","volume":"17","author":"Raatikainen","year":"2016","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B117","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jacc.2017.11.020","article-title":"Impaired recovery of left ventricular function in patients with cardiomyopathy and left bundle branch block","volume":"71","author":"Sze","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B118","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/ejhf.2046","article-title":"Optimized implementation of cardiac resynchronization therapy: a call for action for referral and optimization of care: a joint position statement from the Heart Failure Association (HFA), European Heart Rhythm Association (EHRA), and European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology","volume":"22","author":"Mullens","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"2022102518223435600_ehac088-B119","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/europace\/eus222","article-title":"2012 EHRA\/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management","volume":"14","author":"Daubert","year":"2012","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B120","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1016\/j.jacc.2019.09.043","article-title":"Evaluation, management, and outcomes of patients poorly responsive to cardiac resynchronization device therapy","volume":"74","author":"Varma","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2022102518223435600_ehac088-B121","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/jamainternmed.2014.2717","article-title":"Cardiac resynchronization therapy in women: US food and drug administration meta-analysis of patient-level data","volume":"174","author":"Zusterzeel","year":"2014","journal-title":"JAMA Intern Med"},{"key":"2022102518223435600_ehac088-B122","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ejhf.1133","article-title":"The interaction of sex, height, and QRS duration on the effects of cardiac resynchronization therapy on morbidity and mortality: an individual-patient data meta-analysis. Results from a case based meta-analysis","volume":"20","author":"Linde","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2022102518223435600_ehac088-B123","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacep.2017.02.021","article-title":"Sex-specific response to cardiac resynchronization therapy: effect of left ventricular size and QRS duration in left bundle branch block","volume":"3","author":"Varma","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"2022102518223435600_ehac088-B124","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/europace\/euz225","article-title":"In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry: sex differences","volume":"22","author":"Grecu","year":"2020","journal-title":"Europace"},{"key":"2022102518223435600_ehac088-B125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijcard.2017.02.007","article-title":"Risk factor algorithm used to predict frequent premature ventricular contraction-induced cardiomyopathy","volume":"233","author":"Park","year":"2017","journal-title":"Int J Cardiol"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/43\/20\/1917\/46631841\/ehac088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/43\/20\/1917\/46631841\/ehac088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T14:36:16Z","timestamp":1666708576000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/43\/20\/1917\/6546052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":125,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,3,10]]},"published-print":{"date-parts":[[2022,5,21]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehac088","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5,21]]},"published":{"date-parts":[[2022,3,10]]}}}